AU2295988A - Renin-inhibiting dipeptides, a process for the preparation thereof, agents containing them, and their use - Google Patents

Renin-inhibiting dipeptides, a process for the preparation thereof, agents containing them, and their use

Info

Publication number
AU2295988A
AU2295988A AU22959/88A AU2295988A AU2295988A AU 2295988 A AU2295988 A AU 2295988A AU 22959/88 A AU22959/88 A AU 22959/88A AU 2295988 A AU2295988 A AU 2295988A AU 2295988 A AU2295988 A AU 2295988A
Authority
AU
Australia
Prior art keywords
renin
preparation
agents containing
dipeptides
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU22959/88A
Other versions
AU624579B2 (en
Inventor
Heinz-Werner Kleemann
Dieter Ruppert
Bernward Scholkens
Hansjorg Urbach
Adalbert Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU2295988A publication Critical patent/AU2295988A/en
Application granted granted Critical
Publication of AU624579B2 publication Critical patent/AU624579B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU22959/88A 1987-09-30 1988-09-29 Renin-inhibiting dipeptides, a process for the preparation thereof, agents containing them, and their use Ceased AU624579B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3732971 1987-09-30
DE19873732971 DE3732971A1 (en) 1987-09-30 1987-09-30 RENINE INHIBITING DIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THE AGENTS CONTAINING THEM AND THEIR USE

Publications (2)

Publication Number Publication Date
AU2295988A true AU2295988A (en) 1989-06-29
AU624579B2 AU624579B2 (en) 1992-06-18

Family

ID=6337246

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22959/88A Ceased AU624579B2 (en) 1987-09-30 1988-09-29 Renin-inhibiting dipeptides, a process for the preparation thereof, agents containing them, and their use

Country Status (13)

Country Link
EP (1) EP0310015A3 (en)
JP (1) JPH01121258A (en)
KR (1) KR890005146A (en)
AU (1) AU624579B2 (en)
DE (1) DE3732971A1 (en)
DK (1) DK543788A (en)
FI (1) FI884455A (en)
HU (1) HU203118B (en)
IL (1) IL87912A0 (en)
NO (1) NO884324L (en)
NZ (1) NZ226361A (en)
PT (1) PT88622B (en)
ZA (1) ZA887264B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU613956B2 (en) * 1987-09-16 1991-08-15 Abbott Laboratories Peptidylheterocycles
AU618340B2 (en) * 1988-04-28 1991-12-19 Merck Patent Gesellschaft Mit Beschrankter Haftung Amino acid derivatives
AU626535B2 (en) * 1988-02-16 1992-08-06 Hoechst Aktiengesellschaft Renin-inhibiting amino acid derivatives
AU630386B2 (en) * 1988-12-09 1992-10-29 Hoechst Aktiengesellschaft Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3913290A1 (en) * 1989-04-22 1990-10-25 Hoechst Ag RENIN-INHIBITING DI- AND TRIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THEIR USE
TW225540B (en) * 1990-06-28 1994-06-21 Shionogi & Co
US5554641A (en) * 1995-03-20 1996-09-10 Horwell; David C. Nonpeptides as tachykinin antagonists
JP4696352B2 (en) * 2000-11-30 2011-06-08 トヨタ自動車株式会社 Vehicle power supply

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3538749A1 (en) * 1985-10-31 1987-05-07 Merck Patent Gmbh PEPTIDE
DE3601248A1 (en) * 1986-01-17 1987-07-23 Hoechst Ag SUBSTITUTED 4-AMINO-3-HYDROXYBUTTERIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
DE3627877A1 (en) * 1986-07-30 1988-02-04 Hoechst Ag RENINE-INHIBITING DI- AND TRIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
HU204285B (en) * 1986-10-31 1991-12-30 Pfizer Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them
CH676988A5 (en) * 1987-01-21 1991-03-28 Sandoz Ag

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU613956B2 (en) * 1987-09-16 1991-08-15 Abbott Laboratories Peptidylheterocycles
AU626535B2 (en) * 1988-02-16 1992-08-06 Hoechst Aktiengesellschaft Renin-inhibiting amino acid derivatives
AU618340B2 (en) * 1988-04-28 1991-12-19 Merck Patent Gesellschaft Mit Beschrankter Haftung Amino acid derivatives
AU630386B2 (en) * 1988-12-09 1992-10-29 Hoechst Aktiengesellschaft Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof

Also Published As

Publication number Publication date
DK543788D0 (en) 1988-09-29
HUT48278A (en) 1989-05-29
KR890005146A (en) 1989-05-13
PT88622B (en) 1993-07-30
FI884455A0 (en) 1988-09-28
NO884324L (en) 1989-03-31
IL87912A0 (en) 1989-03-31
DE3732971A1 (en) 1989-04-20
ZA887264B (en) 1989-06-28
EP0310015A3 (en) 1992-05-20
EP0310015A2 (en) 1989-04-05
PT88622A (en) 1989-07-31
DK543788A (en) 1989-03-31
NO884324D0 (en) 1988-09-29
FI884455A (en) 1989-03-31
AU624579B2 (en) 1992-06-18
JPH01121258A (en) 1989-05-12
HU203118B (en) 1991-05-28
NZ226361A (en) 1991-12-23

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