AU5371190A - Renin-inhibiting dipeptides, a process for their preparation, agents containing them and their use - Google Patents

Renin-inhibiting dipeptides, a process for their preparation, agents containing them and their use

Info

Publication number
AU5371190A
AU5371190A AU53711/90A AU5371190A AU5371190A AU 5371190 A AU5371190 A AU 5371190A AU 53711/90 A AU53711/90 A AU 53711/90A AU 5371190 A AU5371190 A AU 5371190A AU 5371190 A AU5371190 A AU 5371190A
Authority
AU
Australia
Prior art keywords
renin
preparation
agents containing
dipeptides
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU53711/90A
Other versions
AU622014B2 (en
Inventor
Wolfgang Linz
Dieter Ruppert
Bernward Scholkens
Hansjorg Urbach
Adalbert Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU5371190A publication Critical patent/AU5371190A/en
Application granted granted Critical
Publication of AU622014B2 publication Critical patent/AU622014B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU53711/90A 1989-04-22 1990-04-23 Renin-inhibiting dipeptides, a process for their preparation, agents containing them and their use Ceased AU622014B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3913290 1989-04-22
DE3913290A DE3913290A1 (en) 1989-04-22 1989-04-22 RENIN-INHIBITING DI- AND TRIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THEIR USE

Publications (2)

Publication Number Publication Date
AU5371190A true AU5371190A (en) 1990-11-01
AU622014B2 AU622014B2 (en) 1992-03-26

Family

ID=6379231

Family Applications (1)

Application Number Title Priority Date Filing Date
AU53711/90A Ceased AU622014B2 (en) 1989-04-22 1990-04-23 Renin-inhibiting dipeptides, a process for their preparation, agents containing them and their use

Country Status (15)

Country Link
EP (1) EP0394829A1 (en)
JP (1) JPH02295999A (en)
KR (1) KR900016256A (en)
CN (1) CN1047085A (en)
AU (1) AU622014B2 (en)
CA (1) CA2015071A1 (en)
CS (1) CS198090A2 (en)
DE (1) DE3913290A1 (en)
FI (1) FI901958A0 (en)
HU (1) HU204070B (en)
IL (1) IL94143A0 (en)
MA (1) MA21811A1 (en)
NO (1) NO901758L (en)
PT (1) PT93798A (en)
ZA (1) ZA902996B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8929070D0 (en) * 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
WO1994006755A1 (en) * 1992-09-18 1994-03-31 Japan Tobacco Inc. Alcohol derivative having renin-inhibiting activity and use thereof
US5554641A (en) * 1995-03-20 1996-09-10 Horwell; David C. Nonpeptides as tachykinin antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0163237A3 (en) * 1984-05-29 1988-04-27 Merck & Co. Inc. Di- and tri-peptidal renin inhibitors
US4657931A (en) * 1985-05-15 1987-04-14 G. D. Searle & Co. N-(acyldipeptidyl)-aminoglycols
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
DE3627877A1 (en) * 1986-07-30 1988-02-04 Hoechst Ag RENINE-INHIBITING DI- AND TRIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THESE AGENTS AND THEIR USE
DE3721855A1 (en) * 1987-03-12 1988-09-22 Merck Patent Gmbh AMINO ACID DERIVATIVES
DE3717631A1 (en) * 1987-05-26 1988-12-15 Merck Patent Gmbh AMINO ACID DERIVATIVES
DE3732971A1 (en) * 1987-09-30 1989-04-20 Hoechst Ag RENINE INHIBITING DIPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THE AGENTS CONTAINING THEM AND THEIR USE

Also Published As

Publication number Publication date
KR900016256A (en) 1990-11-13
NO901758L (en) 1990-10-23
ZA902996B (en) 1990-12-28
HU902499D0 (en) 1990-08-28
CA2015071A1 (en) 1990-10-22
EP0394829A1 (en) 1990-10-31
MA21811A1 (en) 1990-12-31
FI901958A0 (en) 1990-04-19
PT93798A (en) 1990-11-20
NO901758D0 (en) 1990-04-20
DE3913290A1 (en) 1990-10-25
IL94143A0 (en) 1991-01-31
JPH02295999A (en) 1990-12-06
HU204070B (en) 1991-11-28
CS198090A2 (en) 1991-08-13
AU622014B2 (en) 1992-03-26
CN1047085A (en) 1990-11-21

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