ZA887160B - Anti-retroviral castanospermine esters - Google Patents

Anti-retroviral castanospermine esters

Info

Publication number
ZA887160B
ZA887160B ZA887160A ZA887160A ZA887160B ZA 887160 B ZA887160 B ZA 887160B ZA 887160 A ZA887160 A ZA 887160A ZA 887160 A ZA887160 A ZA 887160A ZA 887160 B ZA887160 B ZA 887160B
Authority
ZA
South Africa
Prior art keywords
retroviral
castanospermine esters
castanospermine
esters
aids
Prior art date
Application number
ZA887160A
Other languages
English (en)
Inventor
Paul S Lui
S Lui Paul
Sai Prasad Sunkara
Prasad Sunkara Sai
Terry L Bowlin
L Bowlin Terry
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA887160B publication Critical patent/ZA887160B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA887160A 1987-09-29 1988-09-23 Anti-retroviral castanospermine esters ZA887160B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/102,070 US5004746A (en) 1987-09-29 1987-09-29 Anti-retroviral castanospermine esters

Publications (1)

Publication Number Publication Date
ZA887160B true ZA887160B (en) 1989-05-30

Family

ID=22287973

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA887160A ZA887160B (en) 1987-09-29 1988-09-23 Anti-retroviral castanospermine esters

Country Status (12)

Country Link
US (1) US5004746A (de)
EP (1) EP0309952B1 (de)
JP (1) JP2761898B2 (de)
KR (1) KR960009416B1 (de)
AT (1) ATE107506T1 (de)
AU (1) AU614993B2 (de)
DE (1) DE3850335T2 (de)
DK (1) DK172788B1 (de)
ES (1) ES2058201T3 (de)
IE (1) IE64311B1 (de)
PH (1) PH24431A (de)
ZA (1) ZA887160B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE126696T1 (de) * 1985-12-23 1995-09-15 Hutchinson Fred Cancer Res Regulierung der retroviralen replikation, infektion und pathogenese.
US4952585A (en) * 1988-12-15 1990-08-28 Merrell Dow Pharmaceuticals Inc. Castanospermine esters in the inhibition of tumor metastasis
ZA908134B (en) * 1989-10-17 1991-07-31 Merrell Dow Pharma Esters of castanosperime in the treatment of cerebral malaria
US5214050A (en) * 1989-10-17 1993-05-25 Merrell Dow Pharmaceuticals Inc. Esters of castanospermine in the treatment of cerebral malaria
GB8924292D0 (en) * 1989-10-27 1989-12-13 Novalal Ltd The production of a novel dimer chemical product"novo dimers"by the polymersation of indolizidine alkaloids using cyclo dextrin glucosyl transferase
US5028614A (en) * 1990-03-30 1991-07-02 Merrell Dow Pharmaceuticals Inc. Hydroxymethyl-indolizidines and quinolizidines and their use as α-glucosidase I inhibitors
GB9027433D0 (en) * 1990-12-18 1991-02-06 Merrell Dow Pharma Anti-herpes castanospermine esters
US5939430A (en) * 1993-02-22 1999-08-17 Merrell Pharmaceuticals Inc. Combinations of retroviral inhibitors
GB9303518D0 (en) * 1993-02-22 1993-04-07 Merrell Dow Pharma Combinations of retroviral inhibitors
US5959111A (en) * 1997-05-22 1999-09-28 Hoechst Marion Roussel, Inc. Process for preparing 6-0-monoesters of castanospermine
AU739675B2 (en) * 1997-05-22 2001-10-18 Aventisub Ii Inc. Process for preparing 6-O-monoesters of castanospermine
GB0110832D0 (en) * 2001-05-03 2001-06-27 Virogen Ltd Antiviral compounds
US20060052414A1 (en) * 2004-08-13 2006-03-09 Migenix, Inc. Compositions and methods for treating or preventing Hepadnaviridae infection
CA2583351A1 (en) * 2004-10-06 2006-04-13 Migenix Inc. Combination anti-viral compositions comprising castanospermine and methods of use
WO2008088581A2 (en) * 2006-08-02 2008-07-24 United Therapeutics Corporation Liposome treatment of viral infections
WO2009118658A2 (en) * 2008-03-26 2009-10-01 University Of Oxford Endoplasmic reticulum targeting liposomes
JP2012521981A (ja) * 2009-03-27 2012-09-20 ザ チャンセラー，マスターズ アンド スカラーズ オブ ザ ユニバーシティ オブ オックスフォード コレステロールレベル低下リポソーム
EP4106752A4 (de) 2020-02-21 2024-03-20 Florida State University Research Foundation, Inc. Behandlung von infektionen mit dem humanen coronavirus unter verwendung von alpha-glucosidase-glykoprotein-prozessierungsinhibitoren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE126696T1 (de) * 1985-12-23 1995-09-15 Hutchinson Fred Cancer Res Regulierung der retroviralen replikation, infektion und pathogenese.
ZA883925B (en) * 1987-06-08 1989-02-22 Merrell Dow Pharma Inhibitors of glycoprotein processing having anti-retroviral activity
CA1315276C (en) * 1987-07-02 1993-03-30 Paul S. Liu Castanospermine esters and glycosides
US4952585A (en) * 1988-12-15 1990-08-28 Merrell Dow Pharmaceuticals Inc. Castanospermine esters in the inhibition of tumor metastasis

Also Published As

Publication number Publication date
IE882933L (en) 1989-03-29
JPH01106821A (ja) 1989-04-24
DK538888A (da) 1989-03-30
EP0309952A3 (en) 1990-09-26
DK172788B1 (da) 1999-07-19
DE3850335T2 (de) 1994-10-13
JP2761898B2 (ja) 1998-06-04
IE64311B1 (en) 1995-07-26
ATE107506T1 (de) 1994-07-15
EP0309952B1 (de) 1994-06-22
KR960009416B1 (en) 1996-07-19
DK538888D0 (da) 1988-09-28
KR890004701A (ko) 1989-05-09
AU2280288A (en) 1989-04-06
DE3850335D1 (de) 1994-07-28
US5004746A (en) 1991-04-02
PH24431A (en) 1990-06-25
ES2058201T3 (es) 1994-11-01
EP0309952A2 (de) 1989-04-05
AU614993B2 (en) 1991-09-19

Similar Documents

Publication Publication Date Title
KR960009416B1 (en) Anti-retroviral castanospermine esters
DK441786D0 (da) Nucleosider, der kan anvendes terapeutisk
PH25907A (en) Agents for the prophylaxis and therapy of retroviral infections
EP0296573A3 (en) Novel nucleosides, their preparation and pharmaceutical novel nucleosides, their preparation and pharmaceutical compositions compositions
GR3006366T3 (de)
EP0295538A3 (de) Inhibitoren der Glykoprotein-Verarbeitung mit anti-retroviraler Aktivität
AU4426289A (en) Methods for interfering with hiv multiplication and composition for the treatment of aids
ATE126435T1 (de) Antiherpes-castanosperminester.
GB2206113B (en) 6-substituted penem esters as anti-inflammatory and anti-degenerative agents
DE69015411D1 (de) 5,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one und -thione und deren Verwendung bei der Vorbeugung und und Behandlung von AIDS.
OA09507A (en) Compositions and methods for treating or preventing AIDS ARC and HIV infection
JPS6452781A (en) Novel antitumoral and antiviral composition from mrine source
AU1792788A (en) Rubradirin derivatives for treatment of hiv infection
AU98542S (en) Bat
ZA892627B (en) Hiv protease inhibitors useful for the treatment of aids
ZA896430B (en) Hiv protease inhibitors useful for the treatment of aids
ZA882667B (en) Agents for the prophylaxis and therapy of retroviral infections
FI925209A (fi) Foerfarande foer framstaellning av terapeutiskt aktiva heterocykliskt substituerade foereningar