DK441786D0 - Nucleosider, der kan anvendes terapeutisk - Google Patents

Nucleosider, der kan anvendes terapeutisk

Info

Publication number
DK441786D0
DK441786D0 DK441786A DK441786A DK441786D0 DK 441786 D0 DK441786 D0 DK 441786D0 DK 441786 A DK441786 A DK 441786A DK 441786 A DK441786 A DK 441786A DK 441786 D0 DK441786 D0 DK 441786D0
Authority
DK
Denmark
Prior art keywords
azidonucleosides
nucleosides
pharmaceutically acceptable
acceptable derivatives
used therapeutic
Prior art date
Application number
DK441786A
Other languages
English (en)
Other versions
DK167377B1 (da
DK441786A (da
Inventor
J L Rideout
D W Barry
S N Lehrman
Clair M H St
P A Furman
G A Freeman
T P Zimmerman
G Wolberg
P M De Miranda
S R Shaver
L E Kirk
D H King
R H Clemons
G White
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/776,899 external-priority patent/US4724232A/en
Priority claimed from GB858523878A external-priority patent/GB8523878D0/en
Priority claimed from GB868603447A external-priority patent/GB8603447D0/en
Priority claimed from GB868603719A external-priority patent/GB8603719D0/en
Priority claimed from GB868608272A external-priority patent/GB8608272D0/en
Priority claimed from GB868615322A external-priority patent/GB8615322D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DK441786D0 publication Critical patent/DK441786D0/da
Publication of DK441786A publication Critical patent/DK441786A/da
Application granted granted Critical
Publication of DK167377B1 publication Critical patent/DK167377B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK441786A 1985-09-17 1986-09-15 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion DK167377B1 (da)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US77689985 1985-09-17
US06/776,899 US4724232A (en) 1985-03-16 1985-09-17 Treatment of human viral infections
GB858523878A GB8523878D0 (en) 1985-09-27 1985-09-27 Therapeutic compounds
GB8523878 1985-09-27
GB8603447 1986-02-12
GB868603447A GB8603447D0 (en) 1986-02-12 1986-02-12 Therapeutic compounds
GB868603719A GB8603719D0 (en) 1986-02-14 1986-02-14 Antiviral compounds
GB8603719 1986-02-14
GB868608272A GB8608272D0 (en) 1986-04-04 1986-04-04 Antiviral combination
GB8608272 1986-04-04
US87779686A 1986-06-23 1986-06-23
US87728486A 1986-06-23 1986-06-23
GB868615322A GB8615322D0 (en) 1986-06-23 1986-06-23 Antiviral combinations
US87779686 1986-06-23
US87728486 1986-06-23
GB8615322 1986-06-23

Publications (3)

Publication Number Publication Date
DK441786D0 true DK441786D0 (da) 1986-09-15
DK441786A DK441786A (da) 1987-03-18
DK167377B1 DK167377B1 (da) 1993-10-25

Family

ID=27571236

Family Applications (2)

Application Number Title Priority Date Filing Date
DK441786A DK167377B1 (da) 1985-09-17 1986-09-15 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion
DK911987A DK198791D0 (da) 1985-09-17 1991-12-10 Terapeutiske kombinationer af 3'-azido-3'-desoxythymidin og andre terapeutiske midler

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK911987A DK198791D0 (da) 1985-09-17 1991-12-10 Terapeutiske kombinationer af 3'-azido-3'-desoxythymidin og andre terapeutiske midler

Country Status (7)

Country Link
EP (1) EP0217580A3 (da)
AT (1) ATE190064T1 (da)
AU (1) AU595832B2 (da)
CA (1) CA1302263C (da)
DE (1) DE3650741T2 (da)
DK (2) DK167377B1 (da)
GB (1) GB2181128A (da)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
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ATE190064T1 (de) * 1985-09-17 2000-03-15 Wellcome Found Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten.
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US5455339A (en) * 1986-05-01 1995-10-03 University Of Georgia Research Foundation, Inc. Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides
US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US5084445A (en) * 1986-05-01 1992-01-28 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine
EP0332626A1 (en) * 1986-11-21 1989-09-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Compositions for treating viral infections in humans
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
GB8629892D0 (en) * 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
US5190926A (en) * 1987-01-28 1993-03-02 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
HU199865B (en) * 1987-03-16 1990-03-28 Wellcome Found Process for production of healing nucleosides and medical compositions containing them
EP0286825A3 (en) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
US5214048A (en) * 1987-05-19 1993-05-25 Nippon Kayaku Kabushiki Kaisha Oxetanocins
IL86381A0 (en) * 1987-05-19 1988-11-15 Nippon Kayaku Kk Oxetanocins and pharmaceutical compositions containing the same
USRE33887E (en) * 1987-06-22 1992-04-14 Hoffmann-La Roche Inc. Anti-retroviral compounds
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds
EP0300073A1 (en) * 1987-07-22 1989-01-25 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Use of fusidic acid in the treatment of aids-related complex and full-blown aids
WO1989000424A1 (en) * 1987-07-22 1989-01-26 Leo Pharmaceutical Products B.V. Fusidic acid useful in the treatment of aids
GB8719877D0 (en) * 1987-08-22 1987-09-30 Wellcome Found Antiviral compounds
US4954485A (en) * 1987-10-20 1990-09-04 Sanyo-Kokusaku Pulp Co., Ltd. 2',3'-dideoxy-4-thio-uridine derivatives, process for their preparation and antivirus agents using them
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
SU1548182A1 (ru) * 1987-12-29 1990-03-07 Институт молекулярной биологии АН СССР 5 @ -Фосфонаты 3 @ -азидо-2 @ ,3 @ -дидезоксинуклеозидов, вл ющиес специфическими ингибиторами вируса СПИД в культуре лимфоцитов человека Н9/ШВ
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
US5077280A (en) * 1988-04-12 1991-12-31 Brown University Research Foundation Treatment of viral infections
EP0348170A3 (en) * 1988-06-21 1990-12-05 Moses Nam Fong Lee Antiviral pyrimidine derivatives
US4987224A (en) * 1988-08-02 1991-01-22 University Of Georgia Research Foundation, Inc. Method of preparation of 2',3'-dideoxynucleosides
EP0355031A3 (de) * 1988-08-17 1990-12-27 MATTHES, Eckart, Dr. Substituierte Pyrimidinnucleoside, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
FR2635778A1 (fr) * 1988-08-26 1990-03-02 Ire Celltarg Sa Nouveaux derives de la 3(prime) azido-3(prime) deoxythymidine (azt) actifs contre le virus hiv du sida
EP0362162B1 (en) * 1988-09-28 1992-03-04 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Pharmaceutical composition comprising zidovudine and inosiplex or components thereof for the treatment of aids and aids-related syndromes
WO1990003978A1 (en) * 1988-10-03 1990-04-19 Stichting Rega Vzw 5-halogeno-3'-fluoro-2',3'-dideoxyuridine compounds and their therapeutic application
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
GR1000522B (el) * 1988-10-11 1992-08-25 Medivir Ab Μεθοδος παρασκευης νεων αναλογων νουκλεοζιτων.
US5051361A (en) * 1988-10-19 1991-09-24 Sigma Chemical Company AZT immunoassays, derivatives, conjugates and antibodies
FI895514A0 (fi) * 1988-11-21 1989-11-20 Syntex Inc Antivirala aemne.
GB8827337D0 (en) * 1988-11-23 1988-12-29 Medical Res Council Nucleoside analogues
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
KR910007655A (ko) * 1989-10-03 1991-05-30 엠. 피. 잭슨 치료용 뉴클레오시드
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
FR2656867A1 (fr) * 1990-01-09 1991-07-12 Centre Nat Rech Scient Nouveau derives de la thymidine, leur preparation et les compositions qui les contiennent.
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US6069252A (en) * 1990-02-01 2000-05-30 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
CA2079796A1 (en) * 1990-04-04 1991-10-05 Jo Klaveness Nucleoside derivatives
US5128458A (en) * 1990-04-20 1992-07-07 Southern Research Institute 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
US5192749A (en) * 1990-05-21 1993-03-09 Syntex (U.S.A.) Inc. 4'-substituted nucleosides
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
GB9105899D0 (en) * 1991-03-20 1991-05-08 Wellcome Found Therapeutic nucleosides
DE4110977A1 (de) * 1991-04-05 1992-10-08 Bayer Ag Substituierte 2',3'-didesoxy-5-trifluormethyluridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
FR2677026A1 (fr) * 1991-05-30 1992-12-04 Univ Paris Curie Nucleosides a base modifiee.
DE550714T1 (de) * 1991-06-21 1995-06-14 Acic Canada Inc Antiviralverbindungen und Ihrer Verfahren zur Herstellung.
US5231174A (en) * 1992-02-27 1993-07-27 University Of Iowa Research Foundation 2'isodideoxy-β-D-nucleosides as stable antiviral agents
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
US5849905A (en) * 1994-11-23 1998-12-15 Centre National De La Recherche Scientifique Biologically active phosphotriester-type nucleosides and methods for preparing same
FR2692265B1 (fr) 1992-05-25 1996-11-08 Centre Nat Rech Scient Composes biologiquement actifs de type phosphotriesters.
US6020482A (en) * 1992-05-25 2000-02-01 Gosselin; Gilles Phosphotriester type biologically active compounds
US5770725A (en) * 1992-05-25 1998-06-23 Gosselin; Gilles Phosphotriester type biologically active compounds
FR2691463A1 (fr) * 1992-05-25 1993-11-26 Centre Nat Rech Scient Dérivés nucléotidiques, leur préparation et leur application en thérapeutique.
NL9300058A (nl) * 1992-06-18 1994-01-17 Stichting Rega V Z W 1,5-anhydrohexitol nucleoside analoga en farmaceutisch gebruik daarvan.
US5451671A (en) * 1992-07-27 1995-09-19 Ajinomoto Co., Inc. Method of purifying 2',3'-dideoxynucleosides
US5955591A (en) * 1993-05-12 1999-09-21 Imbach; Jean-Louis Phosphotriester oligonucleotides, amidites and method of preparation
US5567689A (en) * 1993-08-13 1996-10-22 The Uab Research Foundation Methods for increasing uridine levels with L-nucleosides
WO1995007086A1 (en) * 1993-09-10 1995-03-16 Emory University Nucleosides with anti-hepatitis b virus activity
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
AU722214B2 (en) 1995-06-07 2000-07-27 Centre National De La Recherche Scientifique (Cnrs) Nucleosides with anti-hepatitis B virus activity
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
CA2335617C (en) * 1998-06-24 2009-12-15 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (4)

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NL8100177A (nl) * 1981-01-15 1982-08-02 Stichting Rega V Z W 3'-amino- of -azidoderivaten van e-5-(2-halogeenvinyl)-2'-deoxyuridine.
PT82199B (pt) * 1985-03-16 1990-11-07 Wellcome Found Processo para a preparacao de nucleosidos antivirais e de composicoes farmaceuticas que os contem
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
ATE190064T1 (de) * 1985-09-17 2000-03-15 Wellcome Found Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten.

Also Published As

Publication number Publication date
GB2181128A (en) 1987-04-15
DK167377B1 (da) 1993-10-25
DK198791A (da) 1991-12-10
DK441786A (da) 1987-03-18
DE3650741D1 (de) 2000-04-06
AU595832B2 (en) 1990-04-12
ATE190064T1 (de) 2000-03-15
EP0217580A3 (en) 1990-11-07
EP0217580A2 (en) 1987-04-08
CA1302263C (en) 1992-06-02
GB8622194D0 (en) 1986-10-22
DK198791D0 (da) 1991-12-10
DE3650741T2 (de) 2000-10-12
AU6270286A (en) 1987-03-19

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