ZA88655B - 14,15-substituted lanosterols and their use as hypocholesterolemic agents - Google Patents

14,15-substituted lanosterols and their use as hypocholesterolemic agents

Info

Publication number
ZA88655B
ZA88655B ZA88655A ZA88655A ZA88655B ZA 88655 B ZA88655 B ZA 88655B ZA 88655 A ZA88655 A ZA 88655A ZA 88655 A ZA88655 A ZA 88655A ZA 88655 B ZA88655 B ZA 88655B
Authority
ZA
South Africa
Prior art keywords
hypocholesterolemic agents
lanosterols
substituted
substituted lanosterols
hypocholesterolemic
Prior art date
Application number
ZA88655A
Other languages
English (en)
Inventor
James Leroy Gaylor
Leroy Gaylor James
Robert Paul Johnson
Paul Johnson Robert
Soo Sung Ko
Sung Ko Soo
Ronald Louis Magolda
Louis Magolda Ronald
Simon Hendrik Stam
Hendrik Stam Simon
James Michael Trzaskos
Michael Trzaskos James
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of ZA88655B publication Critical patent/ZA88655B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA88655A 1987-01-30 1988-01-29 14,15-substituted lanosterols and their use as hypocholesterolemic agents ZA88655B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US881287A 1987-01-30 1987-01-30
US9063487A 1987-08-28 1987-08-28

Publications (1)

Publication Number Publication Date
ZA88655B true ZA88655B (en) 1989-09-27

Family

ID=26678653

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA88655A ZA88655B (en) 1987-01-30 1988-01-29 14,15-substituted lanosterols and their use as hypocholesterolemic agents

Country Status (17)

Country Link
EP (1) EP0276823B1 (ko)
KR (1) KR880009037A (ko)
AU (1) AU611882B2 (ko)
CA (1) CA1328449C (ko)
DE (1) DE3874763T2 (ko)
DK (1) DK47788A (ko)
ES (1) ES2046217T3 (ko)
FI (1) FI880417A (ko)
GR (1) GR3006422T3 (ko)
HU (1) HUT49145A (ko)
IE (1) IE59999B1 (ko)
IL (1) IL85254A0 (ko)
MY (1) MY102582A (ko)
NO (1) NO880409L (ko)
NZ (1) NZ223344A (ko)
PT (1) PT86665B (ko)
ZA (1) ZA88655B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023250A (en) * 1989-08-24 1991-06-11 Smithkline Beecham Corporation Steroidal 14α-carboxy-alkyl derivatives as regulators of HMG-COA reductase
US5219879A (en) * 1990-03-05 1993-06-15 Du Pont Merck Pharmaceutical Company Heterocyclic steroid compounds
US6093389A (en) * 1997-12-01 2000-07-25 American Cyanamid Company Methods and compositions for attracting and controlling termites
IL139241A0 (en) * 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202891A (en) * 1977-05-16 1980-05-13 Kandutsch Andrew A 15-Oxygenated sterol compounds and the use of such compounds to inhibit the biosynthesis of sterols

Also Published As

Publication number Publication date
GR3006422T3 (ko) 1993-06-21
PT86665A (pt) 1988-02-01
EP0276823B1 (en) 1992-09-23
IL85254A0 (en) 1988-07-31
AU611882B2 (en) 1991-06-27
NO880409L (no) 1988-08-01
HUT49145A (en) 1989-08-28
DK47788A (da) 1988-07-31
EP0276823A2 (en) 1988-08-03
CA1328449C (en) 1994-04-12
DK47788D0 (da) 1988-01-29
IE59999B1 (en) 1994-05-18
KR880009037A (ko) 1988-09-13
AU1117188A (en) 1988-08-04
DE3874763T2 (de) 1993-04-01
NO880409D0 (no) 1988-01-29
NZ223344A (en) 1990-12-21
DE3874763D1 (de) 1992-10-29
FI880417A0 (fi) 1988-01-29
IE880241L (en) 1988-07-30
MY102582A (en) 1992-07-31
PT86665B (pt) 1992-02-28
ES2046217T3 (es) 1994-02-01
EP0276823A3 (en) 1989-01-25
FI880417A (fi) 1988-07-31

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