ZA884388B - New indolylpropanols,processes for their preparation and their use,and preparations containing the compounds - Google Patents
New indolylpropanols,processes for their preparation and their use,and preparations containing the compoundsInfo
- Publication number
- ZA884388B ZA884388B ZA884388A ZA884388A ZA884388B ZA 884388 B ZA884388 B ZA 884388B ZA 884388 A ZA884388 A ZA 884388A ZA 884388 A ZA884388 A ZA 884388A ZA 884388 B ZA884388 B ZA 884388B
- Authority
- ZA
- South Africa
- Prior art keywords
- denotes
- group
- alkylsulphonylalkoxy
- alkylsulphinylalkoxy
- alkoxyalkylsulphinyl
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- -1 difluoromethoxy, difluoromethylthio Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 4
- 125000004984 dialkylaminoalkoxy group Chemical group 0.000 abstract 4
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004076 pyridyl group Chemical group 0.000 abstract 3
- 125000001544 thienyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XQEGFCUBRXTJNF-UHFFFAOYSA-N 1-(1h-indol-2-yl)propan-1-ol Chemical class C1=CC=C2NC(C(O)CC)=CC2=C1 XQEGFCUBRXTJNF-UHFFFAOYSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020852 Hypertonia Diseases 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000009090 positive inotropic effect Effects 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873721260 DE3721260A1 (de) | 1987-06-27 | 1987-06-27 | Neue indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA884388B true ZA884388B (en) | 1989-03-29 |
Family
ID=6330413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA884388A ZA884388B (en) | 1987-06-27 | 1988-06-20 | New indolylpropanols,processes for their preparation and their use,and preparations containing the compounds |
Country Status (11)
Country | Link |
---|---|
US (1) | US4935414A (ja) |
EP (1) | EP0297380B1 (ja) |
JP (1) | JP2577442B2 (ja) |
AT (1) | ATE112565T1 (ja) |
AU (1) | AU609359B2 (ja) |
CA (1) | CA1312078C (ja) |
CY (1) | CY1910A (ja) |
DE (2) | DE3721260A1 (ja) |
ES (1) | ES2064328T3 (ja) |
HK (1) | HK87696A (ja) |
ZA (1) | ZA884388B (ja) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5221674A (en) * | 1989-06-19 | 1993-06-22 | Teikoku Hormone Mfg. Co., Ltd. | Pyridazinone derivatives |
NZ234087A (en) * | 1989-06-19 | 1991-08-27 | Teikoku Hormone Mfg Co Ltd | 2-(3-aryloxy(2-hydroxy-propylamino))-2-methylpropyl- aminophenyl pyridazine derivatives |
DE4002391A1 (de) * | 1990-01-27 | 1991-08-01 | Beiersdorf Ag | Indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
CA2154318A1 (en) * | 1994-08-25 | 1996-02-26 | Richard David Poole | Adaptable radio telephone handset |
US5741789A (en) * | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
US5627196A (en) * | 1995-01-17 | 1997-05-06 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
US5789402A (en) * | 1995-01-17 | 1998-08-04 | Eli Lilly Company | Compounds having effects on serotonin-related systems |
US5614523A (en) * | 1995-01-17 | 1997-03-25 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
CA2228938A1 (en) * | 1995-10-03 | 1997-04-10 | Beiersdorf-Lilly Gmbh | Treatment of atherosclerosis |
US5843938A (en) * | 1995-10-03 | 1998-12-01 | Beiersdorf-Lilly Gmbh | Treatment of atherosclerosis |
EP0766962A3 (en) * | 1995-10-03 | 2000-05-10 | Beiersdorf-Lilly GmbH | Treatment of atherosclerosis |
JP2009220797A (ja) * | 2008-03-19 | 2009-10-01 | Tokuo Suzuki | 特に広範囲な視野を持つバックミラー |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4137331A (en) * | 1974-06-19 | 1979-01-30 | Sandoz Ltd. | 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones |
DE2651574A1 (de) * | 1976-11-12 | 1978-05-18 | Boehringer Mannheim Gmbh | Ein neues aminopropanol-derivat und verfahren zu dessen herstellung |
DE2737630A1 (de) * | 1977-08-20 | 1979-03-01 | Boehringer Mannheim Gmbh | Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE2824677A1 (de) * | 1978-06-06 | 1979-12-20 | Hoechst Ag | Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung |
WO1980000152A1 (en) * | 1978-07-03 | 1980-02-07 | Sandoz Ag | 3-aminopropoxy-aryl derivates,preparation and use thereof |
EP0025111B1 (en) * | 1979-08-10 | 1984-07-25 | Sandoz Ag | 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them |
DE3200304A1 (de) * | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
FR2543952B1 (fr) * | 1982-09-03 | 1986-02-21 | Bristol Myers Co | Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique |
GB2163150B (en) * | 1984-07-19 | 1988-05-25 | Sandoz Ltd | 3-aminopropoxyaryl derivatives |
DE3524955A1 (de) * | 1984-07-19 | 1986-01-30 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
GB8502887D0 (en) * | 1985-02-05 | 1985-03-06 | Sandoz Ltd | Pharmaceutical compositions |
-
1987
- 1987-06-27 DE DE19873721260 patent/DE3721260A1/de not_active Ceased
-
1988
- 1988-06-17 US US07/207,997 patent/US4935414A/en not_active Expired - Lifetime
- 1988-06-20 AT AT88109770T patent/ATE112565T1/de not_active IP Right Cessation
- 1988-06-20 DE DE3851720T patent/DE3851720D1/de not_active Expired - Fee Related
- 1988-06-20 EP EP88109770A patent/EP0297380B1/de not_active Expired - Lifetime
- 1988-06-20 ES ES88109770T patent/ES2064328T3/es not_active Expired - Lifetime
- 1988-06-20 ZA ZA884388A patent/ZA884388B/xx unknown
- 1988-06-22 CA CA000570083A patent/CA1312078C/en not_active Expired - Lifetime
- 1988-06-24 AU AU18334/88A patent/AU609359B2/en not_active Ceased
- 1988-06-27 JP JP63159056A patent/JP2577442B2/ja not_active Expired - Fee Related
-
1996
- 1996-05-16 HK HK87696A patent/HK87696A/xx not_active IP Right Cessation
-
1997
- 1997-03-07 CY CY191097A patent/CY1910A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0297380A3 (en) | 1990-05-09 |
EP0297380B1 (de) | 1994-10-05 |
AU1833488A (en) | 1989-01-05 |
JP2577442B2 (ja) | 1997-01-29 |
DE3851720D1 (de) | 1994-11-10 |
JPS6426558A (en) | 1989-01-27 |
ATE112565T1 (de) | 1994-10-15 |
ES2064328T3 (es) | 1995-02-01 |
DE3721260A1 (de) | 1989-01-12 |
HK87696A (en) | 1996-05-24 |
CY1910A (en) | 1997-03-07 |
US4935414A (en) | 1990-06-19 |
CA1312078C (en) | 1992-12-29 |
EP0297380A2 (de) | 1989-01-04 |
AU609359B2 (en) | 1991-04-26 |
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