ZA883925B - Inhibitors of glycoprotein processing having anti-retroviral activity - Google Patents

Inhibitors of glycoprotein processing having anti-retroviral activity

Info

Publication number
ZA883925B
ZA883925B ZA883925A ZA883925A ZA883925B ZA 883925 B ZA883925 B ZA 883925B ZA 883925 A ZA883925 A ZA 883925A ZA 883925 A ZA883925 A ZA 883925A ZA 883925 B ZA883925 B ZA 883925B
Authority
ZA
South Africa
Prior art keywords
inhibitors
retroviral activity
glycoprotein processing
glycoprotein
retroviral
Prior art date
Application number
ZA883925A
Other languages
English (en)
Inventor
Sai Prasad Sunkara
Prasad Sunkara Sai
Terry L Bowlin
L Bowlin Terry
Paul S Liu
S Liu Paul
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA883925B publication Critical patent/ZA883925B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
ZA883925A 1987-06-08 1988-06-02 Inhibitors of glycoprotein processing having anti-retroviral activity ZA883925B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5896287A 1987-06-08 1987-06-08

Publications (1)

Publication Number Publication Date
ZA883925B true ZA883925B (en) 1989-02-22

Family

ID=22019972

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA883925A ZA883925B (en) 1987-06-08 1988-06-02 Inhibitors of glycoprotein processing having anti-retroviral activity

Country Status (7)

Country Link
EP (1) EP0295538A3 (xx)
JP (1) JP2720169B2 (xx)
KR (1) KR890000097A (xx)
AU (1) AU608853B2 (xx)
DK (1) DK308488A (xx)
PH (1) PH25896A (xx)
ZA (1) ZA883925B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3650377T2 (de) * 1985-12-23 1996-02-22 Hutchinson Fred Cancer Res Regulierung der retroviralen replikation, infektion und pathogenese.
US5004746A (en) * 1987-09-29 1991-04-02 Merrell Dow Pharmaceuticals Inc. Anti-retroviral castanospermine esters
US5192772A (en) * 1987-12-09 1993-03-09 Nippon Shinyaku Co. Ltd. Therapeutic agents
GB8827701D0 (en) * 1987-12-09 1988-12-29 Nippon Shinyaku Co Ltd Thrombolytic &c compositions
FR2632526B1 (fr) * 1988-06-10 1994-05-13 Pasteur Institut Composition pharmaceutique active sur les residus glucose de la glycoproteine gp 150
AU618838B2 (en) * 1988-08-10 1992-01-09 Praxis Pharmaceuticals, Inc. Use of castanospermine as an anti-inflammatory and immunosuppressant agent
WO1990001319A1 (en) * 1988-08-10 1990-02-22 The Australian National University Use of castanospermine as an anti-inflammatory and immunosuppressant agent
US5650413A (en) * 1995-06-07 1997-07-22 Glycodesign Inc. Derivatives of swainsonine, processes for their preparation and their use as therapeutic agents
US5908867A (en) * 1996-07-18 1999-06-01 Henry; James P. Reduction of hair growth
US6048870A (en) * 1996-10-01 2000-04-11 Glycodesign 3, 5, and/or 6 substituted analogues of swainsonine processes for their preparation and their use as therapeutic agents
US6395745B1 (en) 1997-04-15 2002-05-28 Glycodesign, Inc. Alkaloid halide salts of swainsonine and methods of use
US6051711A (en) * 1997-10-24 2000-04-18 Glycodesign Inc. Synthesis of swainsonine salts
CA2312423A1 (en) * 1997-12-11 1999-06-17 The Chancellor, Masters And Scholars Of The University Of Oxford Inhibition of membrane-associated viral replication
US6670374B1 (en) * 2002-06-11 2003-12-30 The United States Of America As Represented By The Secretary Of Agriculture Swainsonine compounds as inhibitors of toxin receptor expression
GB0501352D0 (en) * 2005-01-21 2005-03-02 Slingsby Jason H Use of glycosylation modulators in combination with membrane fusion inhibitors for treatment of infections caused by viruses bearing glycosylated envelope
US20060194835A1 (en) * 2005-02-09 2006-08-31 Migenix Inc. Compositions and methods for treating or preventing flaviviridae infections

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3650377T2 (de) * 1985-12-23 1996-02-22 Hutchinson Fred Cancer Res Regulierung der retroviralen replikation, infektion und pathogenese.
EP0282618A1 (en) * 1987-03-18 1988-09-21 Vereniging Het Nederlands Kanker Instituut 1-Deoxynojirimycin as an anti-HIV therapeutic
DK175094B1 (da) * 1987-12-21 2004-06-01 Monsanto Co Anvendelse af N-butyl-derivatet af deoxynojirimycin til fremstilling af farmaceutisk præparat

Also Published As

Publication number Publication date
DK308488D0 (da) 1988-06-07
KR890000097A (ko) 1989-03-11
PH25896A (en) 1991-12-19
EP0295538A2 (en) 1988-12-21
AU1739788A (en) 1988-12-08
AU608853B2 (en) 1991-04-18
DK308488A (da) 1988-12-09
EP0295538A3 (en) 1991-04-03
JPS63310819A (ja) 1988-12-19
JP2720169B2 (ja) 1998-02-25

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