ZA883599B - Mixed crystals of insulin and insulin derivatives,a process for the preparation of these mixed crystals,pharmaceutical agents containing these mixed crystals,and the use thereof for the treatment of diabetes mellitus - Google Patents
Mixed crystals of insulin and insulin derivatives,a process for the preparation of these mixed crystals,pharmaceutical agents containing these mixed crystals,and the use thereof for the treatment of diabetes mellitusInfo
- Publication number
- ZA883599B ZA883599B ZA883599A ZA883599A ZA883599B ZA 883599 B ZA883599 B ZA 883599B ZA 883599 A ZA883599 A ZA 883599A ZA 883599 A ZA883599 A ZA 883599A ZA 883599 B ZA883599 B ZA 883599B
- Authority
- ZA
- South Africa
- Prior art keywords
- mixed crystals
- insulin
- treatment
- diabetes mellitus
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873717370 DE3717370A1 (de) | 1987-05-22 | 1987-05-22 | Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA883599B true ZA883599B (en) | 1989-01-25 |
Family
ID=6328227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA883599A ZA883599B (en) | 1987-05-22 | 1988-05-20 | Mixed crystals of insulin and insulin derivatives,a process for the preparation of these mixed crystals,pharmaceutical agents containing these mixed crystals,and the use thereof for the treatment of diabetes mellitus |
Country Status (20)
Country | Link |
---|---|
US (1) | US5028587A (fr) |
EP (1) | EP0291863B1 (fr) |
JP (1) | JPS63303930A (fr) |
KR (1) | KR880013572A (fr) |
AT (1) | ATE71842T1 (fr) |
AU (1) | AU601280B2 (fr) |
CA (1) | CA1335924C (fr) |
DE (2) | DE3717370A1 (fr) |
DK (1) | DK278088A (fr) |
ES (1) | ES2032896T3 (fr) |
FI (1) | FI93797C (fr) |
GR (1) | GR3004344T3 (fr) |
HU (1) | HU203840B (fr) |
IE (1) | IE60649B1 (fr) |
IL (1) | IL86452A (fr) |
NO (1) | NO175641C (fr) |
NZ (1) | NZ224715A (fr) |
PH (1) | PH25587A (fr) |
PT (1) | PT87523B (fr) |
ZA (1) | ZA883599B (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
WO1992010284A2 (fr) | 1990-12-07 | 1992-06-25 | Cnc Development, Inc. | Reacteur chimique catalytique |
AU669110B2 (en) * | 1991-05-24 | 1996-05-30 | Amylin Pharmaceuticals, Inc. | Amylin and possibly insulin containing composition for the treatment of anorexia and related states |
DK72793D0 (da) * | 1993-06-21 | 1993-06-21 | Novo Nordisk As | Nyt produkt |
US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
US5547929A (en) * | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
US5597893A (en) * | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
US6004549A (en) * | 1994-12-14 | 1999-12-21 | Schering Corporation | Crystalline protein controlled release compositions |
CO4970787A1 (es) * | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
DE19903125B4 (de) * | 1999-01-27 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga |
CN1125081C (zh) * | 1999-09-08 | 2003-10-22 | 中国科学院上海生物化学研究所 | 重组天然和新型人胰岛素及其制备方法 |
NZ526672A (en) * | 2001-02-09 | 2006-10-27 | Genentech Inc | Process for forming crystalline human insulin-like growth factor-1 |
US7396936B1 (en) | 2004-11-09 | 2008-07-08 | Kemia, Inc. | Modulators of calcitonin and amylin receptor activity |
JP2010510988A (ja) * | 2006-11-28 | 2010-04-08 | マリナス ファーマシューティカルズ | ナノ粒子製剤とその製造方法およびその利用 |
US9822158B2 (en) | 2013-12-04 | 2017-11-21 | Merck Sharp & Dohme Corp. | Method for preparing crystalline insulin |
EP3185887B1 (fr) | 2014-08-26 | 2021-03-10 | Merck Sharp & Dohme Corp. | Procédé de préparation de compositions d'analogue d'insuline ou d'insuline cristallines |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2538018A (en) * | 1944-04-04 | 1951-01-16 | Nordisk Insulinlab | Crystalline product of insulin and alkaline protein and process of making it |
EG12098A (en) * | 1974-04-13 | 1980-12-31 | Hoechst Ag | New pharmaceutical insulin preparations having antidiabetic activity and process for their manufacture |
DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
DE3326473A1 (de) * | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
DE3333640A1 (de) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
-
1987
- 1987-05-22 DE DE19873717370 patent/DE3717370A1/de not_active Withdrawn
-
1988
- 1988-05-13 ES ES198888107667T patent/ES2032896T3/es not_active Expired - Lifetime
- 1988-05-13 AT AT88107667T patent/ATE71842T1/de not_active IP Right Cessation
- 1988-05-13 DE DE8888107667T patent/DE3867903D1/de not_active Expired - Fee Related
- 1988-05-13 EP EP88107667A patent/EP0291863B1/fr not_active Expired - Lifetime
- 1988-05-19 PT PT87523A patent/PT87523B/pt not_active IP Right Cessation
- 1988-05-19 FI FI882354A patent/FI93797C/fi not_active IP Right Cessation
- 1988-05-20 PH PH36954A patent/PH25587A/en unknown
- 1988-05-20 NZ NZ224715A patent/NZ224715A/en unknown
- 1988-05-20 IL IL86452A patent/IL86452A/xx unknown
- 1988-05-20 IE IE152288A patent/IE60649B1/en not_active IP Right Cessation
- 1988-05-20 NO NO882207A patent/NO175641C/no unknown
- 1988-05-20 ZA ZA883599A patent/ZA883599B/xx unknown
- 1988-05-20 US US07/196,530 patent/US5028587A/en not_active Expired - Fee Related
- 1988-05-20 CA CA000567377A patent/CA1335924C/fr not_active Expired - Fee Related
- 1988-05-20 KR KR1019880005946A patent/KR880013572A/ko not_active Application Discontinuation
- 1988-05-20 AU AU16487/88A patent/AU601280B2/en not_active Ceased
- 1988-05-20 JP JP63122211A patent/JPS63303930A/ja active Pending
- 1988-05-20 HU HU882597A patent/HU203840B/hu not_active IP Right Cessation
- 1988-05-20 DK DK278088A patent/DK278088A/da not_active Application Discontinuation
-
1992
- 1992-04-15 GR GR920400389T patent/GR3004344T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE71842T1 (de) | 1992-02-15 |
EP0291863A2 (fr) | 1988-11-23 |
DE3867903D1 (de) | 1992-03-05 |
DK278088A (da) | 1988-11-23 |
IL86452A0 (en) | 1988-11-15 |
HUT46546A (en) | 1988-11-28 |
PH25587A (en) | 1991-08-08 |
AU601280B2 (en) | 1990-09-06 |
NO882207D0 (no) | 1988-05-20 |
NO882207L (no) | 1988-11-23 |
NO175641C (no) | 1994-11-09 |
DE3717370A1 (de) | 1988-12-01 |
IL86452A (en) | 1993-02-21 |
JPS63303930A (ja) | 1988-12-12 |
HU203840B (en) | 1991-10-28 |
AU1648788A (en) | 1988-11-24 |
ES2032896T3 (es) | 1993-03-01 |
FI93797C (fi) | 1995-06-12 |
NZ224715A (en) | 1990-04-26 |
FI882354A (fi) | 1988-11-23 |
EP0291863A3 (en) | 1990-04-04 |
US5028587A (en) | 1991-07-02 |
GR3004344T3 (fr) | 1993-03-31 |
FI882354A0 (fi) | 1988-05-19 |
IE60649B1 (en) | 1994-08-10 |
PT87523A (pt) | 1989-05-31 |
IE881522L (en) | 1988-11-22 |
KR880013572A (ko) | 1988-12-21 |
EP0291863B1 (fr) | 1992-01-22 |
DK278088D0 (da) | 1988-05-20 |
NO175641B (fr) | 1994-08-01 |
FI93797B (fi) | 1995-02-28 |
PT87523B (pt) | 1992-09-30 |
CA1335924C (fr) | 1995-06-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU601280B2 (en) | Mixed crystals of insulin and insulin derivatives, a process for the preparation of these mixed crystals, pharmaceutical agents containing these mixed crystals, and the use thereof for the treatment of diabetes mellitus | |
ZA845620B (en) | Novel insulin derivatives,processes for their preparation and their use,and pharmaceutical agents for the treatment of diabetes mellitus | |
IL82209A0 (en) | Insulin preparation | |
ATE31625T1 (de) | Pharmazeutisches mittel zur behandlung des diabetes mellitus. | |
EP0427247A3 (en) | Pharmaceutical composition with r-alpha-lipoic acid or s-alpha-lipoic acid as the active ingredient | |
YU101385A (en) | Process for obtaining crystal calcium pseudomonate or its hydrate | |
HUT51138A (en) | Process for production of medical composition against osteoporosis containing derivatives of imidasole /1,2-a/-piridasine or pirasine | |
GR861803B (en) | Novel carbonic acid derivatives method for their preparation their use and medicine containing them | |
IL90551A0 (en) | Stable,injectable,aqueous pharmaceutical compositions for the treatment of cardiac conditions | |
HU904201D0 (en) | Process for producing peptides with haemoregulating effect and pharmaceutical preparatives containing these compounds | |
YU222189A (en) | 2-azabicyclo (2.2.1) hept-5-en-2-ocetic acid, it's derivatives and familiar compounds, process for obtaining those compounds and use for obtaining n- phosphono-methylglycine | |
UA8036A1 (uk) | Спосіб одержання похідних тіазолу або їх кислотно-аддітивних солей | |
HUT46904A (en) | Process for production of derivatives of 1,3,5-tritian and medical compounds containing such substances | |
Veyssier et al. | Concentrations of moxalactam in ventricular CSF during the treatment of a Klebsiella pneumoniae. | |
EG19461A (en) | Process for preparing of s-substituted betathioacrylamides and their use as microbicide. | |
SU1840597A1 (ru) | Способ получения бис-(хлороксимино)-ацетона | |
YU125289A (en) | Process for preparing pharmaceutic compounds with delayed effect of healing substance, for oral use, which contains new inclusion complex of nicardipine, or it's hydrochloride with beta-cyclodextrine | |
HU9201315D0 (en) | Process for the production of medical preparations containing 4-/n,n-dibenzyl-amino/-butyric acid or butyric amid as active agent, or their medically useful salts | |
HUT43833A (en) | Process for production of derivatives of 3,4-dihydropirimidin and medical compounds containing thereof |