ZA882385B - Tertiary arylethyl amine derivatives having opiate-antagonistic activity - Google Patents
Tertiary arylethyl amine derivatives having opiate-antagonistic activityInfo
- Publication number
- ZA882385B ZA882385B ZA882385A ZA882385A ZA882385B ZA 882385 B ZA882385 B ZA 882385B ZA 882385 A ZA882385 A ZA 882385A ZA 882385 A ZA882385 A ZA 882385A ZA 882385 B ZA882385 B ZA 882385B
- Authority
- ZA
- South Africa
- Prior art keywords
- arylethyl
- opiate
- tertiary
- antagonistic activity
- amine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8700842A NL8700842A (de) | 1987-04-10 | 1987-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA882385B true ZA882385B (en) | 1988-09-23 |
Family
ID=19849836
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA882385A ZA882385B (en) | 1987-04-10 | 1988-04-05 | Tertiary arylethyl amine derivatives having opiate-antagonistic activity |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0289070A1 (de) |
JP (1) | JPS63290848A (de) |
AU (1) | AU611141B2 (de) |
DK (1) | DK187288A (de) |
IL (1) | IL85996A (de) |
NL (1) | NL8700842A (de) |
NZ (1) | NZ224170A (de) |
ZA (1) | ZA882385B (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8813185D0 (en) * | 1988-06-03 | 1988-07-06 | Wyeth John & Brother Ltd | New method & amines used therein |
GB2249548B (en) * | 1988-06-03 | 1992-10-14 | Wyeth John & Brother Ltd | Aralkyl amine intermediates |
HUT58270A (en) * | 1989-06-02 | 1992-02-28 | Wyeth John & Brother Ltd | Process for producing amine derivatives and pharmaceutical compositions containing them |
FR2681322B1 (fr) * | 1991-09-12 | 1993-12-17 | Laboratorios Dr Esteve Sa | Derives d'aryl-heteroaryl-{n-[2-(3,4-dimethoxyphenyl)-ethyl]-n-methyl-3-aminopropoxy}-methane leur preparation et leur application en tant que medicaments . |
GB9324244D0 (en) * | 1993-11-25 | 1994-01-12 | Merck Sharp & Dohme | Therapeutic agents |
IT1269826B (it) * | 1994-05-24 | 1997-04-15 | Paolo Minoia | Uso di antagonisti degli oppiacei e di sali di calcio per la preparazione di medicamenti per il trattamento di forme patologiche endorfino-mediate |
US20030170917A1 (en) * | 2002-03-01 | 2003-09-11 | Roche Diagnostics Corporation | Compounds, antibodies, reagent kits, methods of producing antibodies, and methods of detecting analytes |
US7101980B2 (en) | 2002-03-01 | 2006-09-05 | Roche Diagnostics Operations, Inc. | Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes |
PL2368554T3 (pl) | 2003-04-08 | 2015-05-29 | Progenics Pharm Inc | Preparaty farmaceutyczne zawierające metylonaltrekson |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
ES2714198T3 (es) | 2005-03-07 | 2019-05-27 | Univ Chicago | Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales |
US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
ES2765811T5 (es) | 2007-03-29 | 2024-02-27 | Progenics Pharm Inc | Forma cristalina de bromuro de (R)-n-metilnaltrexona y sus usos |
ES2540551T3 (es) | 2007-03-29 | 2015-07-10 | Wyeth Llc | Antagonistas de receptores opioides periféricos y usos de los mismos |
PE20090700A1 (es) | 2007-03-29 | 2009-07-13 | Progenics Pharm Inc | Compuestos heterociclicos como antagonistas del receptor opioide periferico |
WO2009099411A1 (en) | 2008-02-06 | 2009-08-13 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
EP2278966B1 (de) | 2008-03-21 | 2019-10-09 | The University of Chicago | Behandlung mit opioid-antagonisten und mtor-inhibitoren |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB586645A (en) * | 1944-07-19 | 1947-03-26 | Burroughs Wellcome Co | Improvements relating to the synthesis of amino acid derivatives and salts thereof |
GB587244A (en) * | 1944-07-21 | 1947-04-18 | Burroughs Wellcome Co | Improvements relating to the synthesis of amino acid derivatives and salts thereof |
DE1493602B2 (de) * | 1965-04-13 | 1976-08-26 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Verfahren zur herstellung von aminoketonen |
DK129033B (da) * | 1968-05-02 | 1974-08-12 | Degussa | Analogifremgangsmåde til fremstilling af propiophenonforbindelser eller deres optisk aktive isomere eller diastereomere eller salte eller kvaternære ammoniumforbindelser deraf. |
NL178686C (nl) * | 1974-04-08 | 1986-05-01 | Duphar Int Res | Werkwijze ter bereiding of vervaardiging van spasmolytisch werkzame preparaten en werkwijze ter bereiding van n-alkyl-n-gesubstitueerd alkylbeta-fenylethylaminen met spasmolytische werking. |
NL7404732A (nl) * | 1974-04-08 | 1975-10-10 | Philips Nv | Spasmolytice. |
US4097500A (en) * | 1977-07-25 | 1978-06-27 | Morton-Norwich Products, Inc. | N-Methyl-5-(4-nitrophenyl)-N-(a-methylphenethyl)furfurylamine hydrochloride |
US4337207A (en) * | 1980-09-04 | 1982-06-29 | Regents Of The University Of California | Biologically active catecholamine derivatives |
NL8202810A (nl) * | 1982-07-12 | 1984-02-01 | Duphar Int Res | Spasmolytisch werkzaam (+)-secoverine. |
NL8300392A (nl) * | 1983-02-03 | 1984-09-03 | Duphar Int Res | Nieuwe spasmolytisch werkzame propylcyclohexylketonderivaten. |
EP0211254A3 (de) * | 1985-07-31 | 1988-05-04 | ASTA Pharma Aktiengesellschaft | Neue cycloaliphatische Ketoamine |
EG18188A (en) * | 1986-05-01 | 1992-09-30 | Pfizer Ltd | Process for preparation anti-arhythmia agents |
-
1987
- 1987-04-10 NL NL8700842A patent/NL8700842A/xx active Search and Examination
-
1988
- 1988-04-05 ZA ZA882385A patent/ZA882385B/xx unknown
- 1988-04-05 JP JP63082373A patent/JPS63290848A/ja active Pending
- 1988-04-06 EP EP88200648A patent/EP0289070A1/de not_active Withdrawn
- 1988-04-06 IL IL85996A patent/IL85996A/xx unknown
- 1988-04-06 DK DK187288A patent/DK187288A/da not_active Application Discontinuation
- 1988-04-07 NZ NZ224170A patent/NZ224170A/en unknown
- 1988-04-07 AU AU14344/88A patent/AU611141B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
DK187288D0 (da) | 1988-04-06 |
AU1434488A (en) | 1988-10-13 |
IL85996A (en) | 1991-12-12 |
NL8700842A (de) | 1988-11-01 |
DK187288A (da) | 1988-10-11 |
IL85996A0 (en) | 1988-09-30 |
JPS63290848A (ja) | 1988-11-28 |
EP0289070A1 (de) | 1988-11-02 |
NZ224170A (en) | 1991-06-25 |
AU611141B2 (en) | 1991-06-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA882385B (en) | Tertiary arylethyl amine derivatives having opiate-antagonistic activity | |
JPS6422857A (en) | Azolylmethyl-cyclopropyl derivative | |
JPS6450883A (en) | N-substituted benzamides | |
IL85247A0 (en) | Novel polyamine derivatives | |
EP0448078A3 (en) | Substituted amine derivatives having anti-hyperlipemia activity | |
CY1665A (en) | Substituted benzamides | |
JPS6434950A (en) | N-aminobutyl-n-phenylarylamide derivative | |
ZW3788A1 (en) | Aliphatic carboxamides | |
GB8701646D0 (en) | Amine derivatives | |
GB8616934D0 (en) | Amine derivatives | |
JPS6471871A (en) | Biarylalkylimidazole derivative | |
EP0277807A3 (en) | Head positioning aid | |
ZA884858B (en) | Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiate-antagonistic activity | |
JPS6426562A (en) | Hydroxyethylazolyl derivative | |
ZA884552B (en) | Carbamate derivatives | |
GB2207673B (en) | New benzamide derivatives | |
GB2214198B (en) | Knitting head | |
ZA888444B (en) | N-substituted dichloromaleimides | |
GB2200353B (en) | Ryfamycin derivative salts | |
JPS6426561A (en) | Azolylmethyl-cyclopropylcarbinol derivative | |
KR900009391Y1 (en) | Head rest | |
GB8902227D0 (en) | Tertiary amine compounds | |
ZA88627B (en) | Connection head | |
IE881034L (en) | Tertiary arylethyl amines | |
IE851474L (en) | Tertiary amine derivatives |