ZA879400B - 2,3-disubstituted isoxazolidines,a process for their preparation,agents containing them,and their use - Google Patents

2,3-disubstituted isoxazolidines,a process for their preparation,agents containing them,and their use

Info

Publication number
ZA879400B
ZA879400B ZA879400A ZA879400A ZA879400B ZA 879400 B ZA879400 B ZA 879400B ZA 879400 A ZA879400 A ZA 879400A ZA 879400 A ZA879400 A ZA 879400A ZA 879400 B ZA879400 B ZA 879400B
Authority
ZA
South Africa
Prior art keywords
isoxazolidines
disubstituted
preparation
agents containing
agents
Prior art date
Application number
ZA879400A
Other languages
English (en)
Inventor
Stephan Henke
Henke Stephan
Dietrich Brocks
Brocks Dietrich
Volkmar Guenzler
Guenzler Volkmar
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA879400B publication Critical patent/ZA879400B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA879400A 1986-12-17 1987-12-15 2,3-disubstituted isoxazolidines,a process for their preparation,agents containing them,and their use ZA879400B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863643012 DE3643012A1 (de) 1986-12-17 1986-12-17 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung

Publications (1)

Publication Number Publication Date
ZA879400B true ZA879400B (en) 1988-07-27

Family

ID=6316346

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA879400A ZA879400B (en) 1986-12-17 1987-12-15 2,3-disubstituted isoxazolidines,a process for their preparation,agents containing them,and their use

Country Status (21)

Country Link
US (2) US5422342A (ja)
EP (1) EP0271865B1 (ja)
JP (1) JP2703912B2 (ja)
KR (1) KR960010349B1 (ja)
AR (1) AR246528A1 (ja)
AT (1) ATE81344T1 (ja)
AU (1) AU599177B2 (ja)
CA (1) CA1338484C (ja)
DE (2) DE3643012A1 (ja)
DK (1) DK171894B1 (ja)
ES (1) ES2052539T3 (ja)
FI (1) FI88303C (ja)
GR (1) GR3006699T3 (ja)
HU (1) HU201961B (ja)
IE (1) IE61034B1 (ja)
IL (1) IL84841A (ja)
NO (1) NO175058B (ja)
NZ (1) NZ222921A (ja)
PH (1) PH24746A (ja)
PT (1) PT86380B (ja)
ZA (1) ZA879400B (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3818850A1 (de) * 1988-06-03 1989-12-07 Hoechst Ag Oligopeptide mit zyklischen prolin-analogen aminosaeuren
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
DE3842197A1 (de) * 1988-12-15 1990-06-21 Hoechst Ag Rasch spaltbares substrat fuer die hiv-protease
DE4016596A1 (de) * 1990-05-23 1991-11-28 Hoechst Ag Ein neues kupplungsreagenz fuer die peptidsynthese
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
DE4443892A1 (de) * 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
EP0796855B1 (de) 1996-03-20 2002-02-06 Hoechst Aktiengesellschaft Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US5801187A (en) * 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
EP1420786A2 (en) * 2001-08-23 2004-05-26 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Methods of inhibiting formation of vascular channels and proliferation using pyridinone derivatives
RU2416606C2 (ru) * 2004-06-17 2011-04-20 Инфинити Дискавери, Инк. Соединения и способы для ингибирования взаимодействия bcl белков с компонентами по связыванию
US7842815B2 (en) 2004-06-17 2010-11-30 Infinity Pharmaceuticals, Inc. Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
TWI389895B (zh) 2006-08-21 2013-03-21 Infinity Discovery Inc 抑制ｂｃｌ蛋白質與結合夥伴間之交互作用的化合物及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944562A (en) * 1974-04-17 1976-03-16 The Upjohn Company αS, 4S, 5R α-Amino-3-chloro-4-hydroxy-2-isoxazoline-5-acetic acid
US4269772A (en) * 1980-01-14 1981-05-26 Merck & Co., Inc. Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
DE3002989A1 (de) * 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
US4562187A (en) * 1985-01-22 1985-12-31 Hoechst-Roussel Pharmaceuticals Inc. (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical use
DE3643957A1 (de) * 1986-12-22 1988-06-30 Bayer Ag Substituierte n-methylisoxazolidine

Also Published As

Publication number Publication date
IL84841A (en) 1992-07-15
DK662087A (da) 1988-06-18
US5610146A (en) 1997-03-11
FI875503A0 (fi) 1987-12-15
PT86380B (pt) 1990-11-20
HU201961B (en) 1991-01-28
GR3006699T3 (ja) 1993-06-30
DE3643012A1 (de) 1988-06-30
DK662087D0 (da) 1987-12-16
FI875503A (fi) 1988-06-18
NO875263D0 (no) 1987-12-16
NO175058B (no) 1994-05-16
NZ222921A (en) 1989-08-29
PT86380A (de) 1988-01-01
EP0271865B1 (de) 1992-10-07
US5422342A (en) 1995-06-06
AR246528A1 (es) 1994-08-31
KR960010349B1 (ko) 1996-07-30
FI88303C (fi) 1993-04-26
AU8258987A (en) 1988-06-23
FI88303B (fi) 1993-01-15
ATE81344T1 (de) 1992-10-15
KR880007497A (ko) 1988-08-27
NO875263L (no) 1988-06-20
IE873418L (en) 1988-06-17
EP0271865A2 (de) 1988-06-22
DE3782149D1 (ja) 1992-11-12
HUT47956A (en) 1989-04-28
AU599177B2 (en) 1990-07-12
IE61034B1 (en) 1994-09-07
CA1338484C (en) 1996-07-23
JP2703912B2 (ja) 1998-01-26
DK171894B1 (da) 1997-08-04
IL84841A0 (en) 1988-06-30
ES2052539T3 (es) 1994-07-16
PH24746A (en) 1990-10-01
EP0271865A3 (en) 1990-02-07
NO175058C (ja) 1994-08-24
JPS63165374A (ja) 1988-07-08

Similar Documents

Publication Publication Date Title
IL67823A0 (en) Fibrinogen formulation,a process for its preparation and its use
IL84841A0 (en) 2,3-disubstituted isoxazolidines,a process for their preparation,agents containing them,and their use
ZA882459B (en) New 2-acylpyrrolidine derivatives,a process for their preparation thereof,agents containing them,and their use
LTIP1720A (en) Novel antiarrhythmic agents, process for the preparation and use thereof
ZA882460B (en) Novel pyrrolidine-2-(1,3-dicarbonyl)derivatives,a process for their preparation,agents containing them,and their use
DE3567638D1 (en) 2,4-dichloro-3-alkyl-6-nitrophenols and process for their preparation
EP0236929A3 (en) 1,2-dithiol-3-thione derivatives, a process for preparing them and a pharmaceutical composition containing them
MTP1014B (en) Substituted aminopropionamides,a process for their preparation,agents containing them,and their use,and new intermediates produced in the preparation (hoe 861f 302)
ZA887264B (en) Renin-inhibiting dipeptides,a process for the preparation thereof,agents containing them,and their use
ZA853687B (en) Biologically active agents containing substituted isoxazolidines,a new isoxazolidines and their preparation
EP0256480A3 (en) Process for the catalic trans-halogenation of a polyiodo-benzene and, in particular, of a di-iodo-benzene
EP0338424A3 (en) N-((6-trifluoromethylpyrimidin-2-yl)-aminocarbonyl)-2-carboalkoxy-benzenesulfonamides, process for their preparation and their use
ZA894381B (en) Substituted 3-aminosydnone imines,a process for their preparation and their use
IL74555A0 (en) Carboxyalkyldipeptides,a process for their preparation,agents containing them,and their use
EP0253413A3 (en) New antibiotics called "mureidomycins a, b, c and d" a process for their preparation and their therapeutic use
PH24164A (en) Oxadiazolone derivatives,production process thereof,and herbicide containing same
IL84987A0 (en) Nitrohaloalkoxybenzenes,a process for their preparation,and their use
ZA882458B (en) Novel pyrrolidine derivatives,a process for their preparation,agents containing these derivatives,and their use
EP0115811A3 (en) 2,4-dichlor-5-thiazolecarboxaldehyd and a process for its preparation
PT81880B (en) (1,2,4-oxadiazol-3-yl)-arymethanones a process for their preparation and their use as medicaments
ZA858249B (en) 1,4-dihydropyridine-hydroxyamines,a process for their preparation and their use in medicaments
GB2199827B (en) Novel aminoalkanoyl-dibenzo[d,g][1,3,6]dioxazocines and a process for the preparation thereof
DE3278931D1 (en) 1,1-diphenylalkenes and a process for their preparation
IL94221A0 (en) Tetrahydroisoquino(2,1,c)(1,3)-benzodiazepines,a process for their preparation and their use as medicaments
ZA861913B (en) Isoxazolidines,process for their preparation,and their use as pest-combating agents