NO875263L - 2,3-disubstituerte isoksazolidiner, fremgangsmaate til deres fremstilling, midler inneholdende disse og deres anvendelse. - Google Patents

2,3-disubstituerte isoksazolidiner, fremgangsmaate til deres fremstilling, midler inneholdende disse og deres anvendelse.

Info

Publication number
NO875263L
NO875263L NO87875263A NO875263A NO875263L NO 875263 L NO875263 L NO 875263L NO 87875263 A NO87875263 A NO 87875263A NO 875263 A NO875263 A NO 875263A NO 875263 L NO875263 L NO 875263L
Authority
NO
Norway
Prior art keywords
isoxsazolidines
disubstituted
procedures
preparation
mentals
Prior art date
Application number
NO87875263A
Other languages
English (en)
Other versions
NO175058B (no
NO175058C (no
NO875263D0 (no
Inventor
Stephan Henke
Dietrich Brocks
Volkmar Gunzler
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO875263D0 publication Critical patent/NO875263D0/no
Publication of NO875263L publication Critical patent/NO875263L/no
Publication of NO175058B publication Critical patent/NO175058B/no
Publication of NO175058C publication Critical patent/NO175058C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0815Tripeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0819Tripeptides with the first amino acid being acidic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO875263A 1986-12-17 1987-12-16 Analogifremgangsmåte for fremstilling av 2,3-disubstituerte isoksazolidiner NO175058B (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863643012 DE3643012A1 (de) 1986-12-17 1986-12-17 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung

Publications (4)

Publication Number Publication Date
NO875263D0 NO875263D0 (no) 1987-12-16
NO875263L true NO875263L (no) 1988-06-20
NO175058B NO175058B (no) 1994-05-16
NO175058C NO175058C (no) 1994-08-24

Family

ID=6316346

Family Applications (1)

Application Number Title Priority Date Filing Date
NO875263A NO175058B (no) 1986-12-17 1987-12-16 Analogifremgangsmåte for fremstilling av 2,3-disubstituerte isoksazolidiner

Country Status (21)

Country Link
US (2) US5422342A (no)
EP (1) EP0271865B1 (no)
JP (1) JP2703912B2 (no)
KR (1) KR960010349B1 (no)
AR (1) AR246528A1 (no)
AT (1) ATE81344T1 (no)
AU (1) AU599177B2 (no)
CA (1) CA1338484C (no)
DE (2) DE3643012A1 (no)
DK (1) DK171894B1 (no)
ES (1) ES2052539T3 (no)
FI (1) FI88303C (no)
GR (1) GR3006699T3 (no)
HU (1) HU201961B (no)
IE (1) IE61034B1 (no)
IL (1) IL84841A (no)
NO (1) NO175058B (no)
NZ (1) NZ222921A (no)
PH (1) PH24746A (no)
PT (1) PT86380B (no)
ZA (1) ZA879400B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3818850A1 (de) * 1988-06-03 1989-12-07 Hoechst Ag Oligopeptide mit zyklischen prolin-analogen aminosaeuren
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
DE3842197A1 (de) * 1988-12-15 1990-06-21 Hoechst Ag Rasch spaltbares substrat fuer die hiv-protease
DE4016596A1 (de) * 1990-05-23 1991-11-28 Hoechst Ag Ein neues kupplungsreagenz fuer die peptidsynthese
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
DE4443892A1 (de) * 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE59706273D1 (de) 1996-03-20 2002-03-21 Hoechst Ag Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
US5801187A (en) * 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US7141589B2 (en) * 2001-08-23 2006-11-28 The United States Of America As Represented By The Department Of Health And Human Services Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation
CN101006065B (zh) * 2004-06-17 2012-07-11 英菲尼蒂发现公司 抑制bcl蛋白与结合伴侣的相互作用的化合物和方法
US7842815B2 (en) 2004-06-17 2010-11-30 Infinity Pharmaceuticals, Inc. Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
TWI389895B (zh) 2006-08-21 2013-03-21 Infinity Discovery Inc 抑制bcl蛋白質與結合夥伴間之交互作用的化合物及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944562A (en) * 1974-04-17 1976-03-16 The Upjohn Company αS, 4S, 5R α-Amino-3-chloro-4-hydroxy-2-isoxazoline-5-acetic acid
US4269772A (en) * 1980-01-14 1981-05-26 Merck & Co., Inc. Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
DE3002989A1 (de) * 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
US4562187A (en) * 1985-01-22 1985-12-31 Hoechst-Roussel Pharmaceuticals Inc. (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical use
DE3643957A1 (de) * 1986-12-22 1988-06-30 Bayer Ag Substituierte n-methylisoxazolidine

Also Published As

Publication number Publication date
KR960010349B1 (ko) 1996-07-30
EP0271865B1 (de) 1992-10-07
AR246528A1 (es) 1994-08-31
DK171894B1 (da) 1997-08-04
ATE81344T1 (de) 1992-10-15
HU201961B (en) 1991-01-28
JP2703912B2 (ja) 1998-01-26
DK662087D0 (da) 1987-12-16
IE61034B1 (en) 1994-09-07
DE3782149D1 (no) 1992-11-12
FI88303C (fi) 1993-04-26
CA1338484C (en) 1996-07-23
FI88303B (fi) 1993-01-15
HUT47956A (en) 1989-04-28
JPS63165374A (ja) 1988-07-08
IL84841A0 (en) 1988-06-30
US5610146A (en) 1997-03-11
PH24746A (en) 1990-10-01
DK662087A (da) 1988-06-18
NO175058B (no) 1994-05-16
NZ222921A (en) 1989-08-29
EP0271865A3 (en) 1990-02-07
US5422342A (en) 1995-06-06
AU599177B2 (en) 1990-07-12
EP0271865A2 (de) 1988-06-22
DE3643012A1 (de) 1988-06-30
ES2052539T3 (es) 1994-07-16
AU8258987A (en) 1988-06-23
KR880007497A (ko) 1988-08-27
FI875503A0 (fi) 1987-12-15
IE873418L (en) 1988-06-17
IL84841A (en) 1992-07-15
GR3006699T3 (no) 1993-06-30
PT86380A (de) 1988-01-01
NO175058C (no) 1994-08-24
FI875503A (fi) 1988-06-18
ZA879400B (en) 1988-07-27
PT86380B (pt) 1990-11-20
NO875263D0 (no) 1987-12-16

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Free format text: LAPSED IN JUNE 2003