ZA875727B - 1,4-dihydropyridine derivatives,the process for preparing them and the pharmaceutical compositions which contain them - Google Patents

1,4-dihydropyridine derivatives,the process for preparing them and the pharmaceutical compositions which contain them

Info

Publication number
ZA875727B
ZA875727B ZA875727A ZA875727A ZA875727B ZA 875727 B ZA875727 B ZA 875727B ZA 875727 A ZA875727 A ZA 875727A ZA 875727 A ZA875727 A ZA 875727A ZA 875727 B ZA875727 B ZA 875727B
Authority
ZA
South Africa
Prior art keywords
preparing
contain
radical
pharmaceutical compositions
dihydropyridine derivatives
Prior art date
Application number
ZA875727A
Other languages
English (en)
Inventor
Jean-Louis Peglion
Peglion Jean-Louis
Yves-Michel Gargouil
Gargouil Yves-Michel
Jean-Paul Vilaine
Vilaine Jean-Paul
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of ZA875727B publication Critical patent/ZA875727B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
ZA875727A 1986-08-04 1987-08-03 1,4-dihydropyridine derivatives,the process for preparing them and the pharmaceutical compositions which contain them ZA875727B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8611260A FR2602231B1 (fr) 1986-08-04 1986-08-04 Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ZA875727B true ZA875727B (en) 1988-04-27

Family

ID=9338004

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA875727A ZA875727B (en) 1986-08-04 1987-08-03 1,4-dihydropyridine derivatives,the process for preparing them and the pharmaceutical compositions which contain them

Country Status (16)

Country Link
US (1) US4870091A (xx)
EP (1) EP0259206B1 (xx)
JP (1) JPS6341460A (xx)
AT (1) ATE68178T1 (xx)
AU (1) AU595353B2 (xx)
CA (1) CA1338637C (xx)
DE (1) DE3773597D1 (xx)
DK (1) DK406587A (xx)
ES (1) ES2004467A6 (xx)
FR (1) FR2602231B1 (xx)
GR (1) GR871231B (xx)
IE (1) IE59985B1 (xx)
NZ (1) NZ221314A (xx)
OA (1) OA08646A (xx)
PT (1) PT85482B (xx)
ZA (1) ZA875727B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2649395B1 (fr) * 1989-07-04 1992-11-06 Adir Nouveau derive de la dihydro-1,4 pyridine denomme (-) Ÿi1Ÿ(((amino-2 ethoxy)-2 ethoxy) methylŸi1Ÿ) -2 (dichloro-2,3 phenyl)-4 ethoxycarbonyl-3 methoxycarbonyl-5 methyl-6 dihydro-1,4 pyridine, son procede de preparation et les compositions qui le contiennent
IT1222591B (it) * 1987-09-04 1990-09-05 Boehringer Biochemia Srl 1,4-diidropiridine 2-alchil- ed alchenil-sostituite,metodo per la loro preparazione e composizione farmaceutiche che le contengono
FR2652083B1 (fr) * 1989-09-20 1992-01-24 Ador Cie Nouveau procede de separation d'isomeres optiques des derives de la dihydro-1,4 pyridine.
FR2686879B1 (fr) * 1992-02-05 1994-03-18 Adir Cie Nouveaux composes de 1,4-dihydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant.
FR2700541B1 (fr) * 1993-01-21 1995-03-03 Adir Nouveaux composés de 1,4-dihydropyridine, leur procédé de préparation et les compositions pharmaceutiques les contenant.
PL362660A1 (en) * 2000-12-29 2004-11-02 Pfizer Limited Process for making amlodipine maleate
CA2433181C (en) * 2000-12-29 2005-11-22 Pfizer Limited Amlodipine hemifumarate
CA2433190C (en) * 2000-12-29 2005-11-15 Pfizer Limited Amlodipine hemimaleate

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658183A1 (de) * 1976-12-22 1978-07-06 Bayer Ag In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4177278A (en) * 1977-04-05 1979-12-04 Bayer Aktiengesellschaft 2-Alkyleneaminodihydropyridines compounds, their production and their medicinal use
JPS5547656A (en) * 1978-09-29 1980-04-04 Dainippon Pharmaceut Co Ltd 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative
DE2844595A1 (de) * 1978-10-13 1980-04-30 Bayer Ag Acylaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
GR851819B (xx) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
EP0174131A3 (en) * 1984-09-01 1989-06-07 FISONS plc Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
JPS61140567A (ja) * 1984-12-13 1986-06-27 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
IT1215298B (it) * 1985-08-06 1990-01-31 Boehringer Biochemia Srl 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione.
DE3531498A1 (de) * 1985-09-04 1987-03-05 Bayer Ag Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
AU595353B2 (en) 1990-03-29
NZ221314A (en) 1990-03-27
DK406587D0 (da) 1987-08-04
US4870091A (en) 1989-09-26
EP0259206B1 (fr) 1991-10-09
PT85482B (pt) 1990-06-29
DK406587A (da) 1988-02-05
PT85482A (fr) 1987-09-01
ES2004467A6 (es) 1989-01-01
IE872090L (en) 1988-02-04
CA1338637C (fr) 1996-10-08
EP0259206A1 (fr) 1988-03-09
OA08646A (fr) 1988-11-30
FR2602231A1 (fr) 1988-02-05
ATE68178T1 (de) 1991-10-15
GR871231B (en) 1987-12-04
JPS6341460A (ja) 1988-02-22
FR2602231B1 (fr) 1988-10-28
DE3773597D1 (de) 1991-11-14
IE59985B1 (en) 1994-05-04
AU7650587A (en) 1988-02-11

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