ZA874106B - Novel antihypertensive agent - Google Patents
Novel antihypertensive agentInfo
- Publication number
- ZA874106B ZA874106B ZA874106A ZA874106A ZA874106B ZA 874106 B ZA874106 B ZA 874106B ZA 874106 A ZA874106 A ZA 874106A ZA 874106 A ZA874106 A ZA 874106A ZA 874106 B ZA874106 B ZA 874106B
- Authority
- ZA
- South Africa
- Prior art keywords
- antihypertensive agent
- novel antihypertensive
- novel
- agent
- antihypertensive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87393986A | 1986-06-13 | 1986-06-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA874106B true ZA874106B (en) | 1987-12-08 |
Family
ID=25362652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA874106A ZA874106B (en) | 1986-06-13 | 1987-06-08 | Novel antihypertensive agent |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0249224A3 (no) |
JP (1) | JPS62298592A (no) |
KR (1) | KR880000400A (no) |
CN (1) | CN87104167A (no) |
AU (1) | AU7402387A (no) |
DK (1) | DK300287A (no) |
FI (1) | FI872612A (no) |
IL (1) | IL82812A0 (no) |
NO (1) | NO872462L (no) |
PT (1) | PT85071A (no) |
ZA (1) | ZA874106B (no) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
AU657793B2 (en) * | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
DE69220744T2 (de) * | 1991-09-27 | 1997-11-13 | Merrell Pharma Inc | 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung |
ZA927211B (en) * | 1991-09-27 | 1993-03-24 | Merrell Dow Pharma | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE. |
US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
DK0625987T3 (da) * | 1992-02-14 | 1999-01-11 | Merrell Pharma Inc | Aminoacetylmercaptoacetylamid-derivater, der kan anvendes som inhibitorer af enkephalinase og ACE |
US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
HU223663B1 (hu) * | 1992-05-15 | 2004-11-29 | Merrel Dow Pharmaceuticals Inc. | Enkefalináz és ACE gátló hatású 9-[(2-acetil-tio-3-fenil)-propanoil-amino]-piridazo[1,2-a][1,2]diazepin-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények |
US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
EP0669936B1 (en) * | 1992-10-30 | 2000-11-22 | Merrell Pharmaceuticals Inc. | Mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace |
US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
HUT76479A (en) * | 1994-02-14 | 1997-09-29 | Merrell Pharma Inc | Novel fused benzazepinone derivatives, process for preparation thereof and pharmaceutical composition containing them |
US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
HUT74584A (en) * | 1994-02-14 | 1997-01-28 | Merrell Pharma Inc | Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them |
KR100357354B1 (ko) * | 1994-02-14 | 2003-01-30 | 메렐 파마슈티칼스 인크. | 엔케팔리나제및안지오텐신전환효소(ace)의억제제로서유용한신규의머캅토아세틸아미드디설파이드유도체 |
WO1995021854A1 (en) * | 1994-02-14 | 1995-08-17 | Merrell Pharmaceuticals Inc. | Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace |
US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
ATE189392T1 (de) * | 1994-03-24 | 2000-02-15 | Merrell Pharma Inc | Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten |
JPH10503468A (ja) * | 1994-03-24 | 1998-03-31 | メリル・フアーマシユウテイカルズ・インコーポレイテツド | 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のメルカプトアセチルアミドジスルフィド誘導体 |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
US5877313A (en) * | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0166354B1 (en) * | 1984-06-26 | 1992-08-05 | Merck & Co. Inc. | Benzofused lactam compounds and pharmaceutical compositions containing them |
US4584294A (en) * | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
-
1987
- 1987-06-08 ZA ZA874106A patent/ZA874106B/xx unknown
- 1987-06-09 IL IL82812A patent/IL82812A0/xx unknown
- 1987-06-09 AU AU74023/87A patent/AU7402387A/en not_active Abandoned
- 1987-06-11 EP EP87108411A patent/EP0249224A3/en not_active Withdrawn
- 1987-06-11 FI FI872612A patent/FI872612A/fi not_active Application Discontinuation
- 1987-06-11 PT PT85071A patent/PT85071A/pt unknown
- 1987-06-12 KR KR870005941A patent/KR880000400A/ko not_active Application Discontinuation
- 1987-06-12 JP JP62145418A patent/JPS62298592A/ja active Pending
- 1987-06-12 NO NO872462A patent/NO872462L/no unknown
- 1987-06-12 CN CN198787104167A patent/CN87104167A/zh active Pending
- 1987-06-12 DK DK300287A patent/DK300287A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL82812A0 (en) | 1987-12-20 |
EP0249224A2 (en) | 1987-12-16 |
AU7402387A (en) | 1987-12-17 |
NO872462D0 (no) | 1987-06-12 |
DK300287D0 (da) | 1987-06-12 |
KR880000400A (ko) | 1988-03-25 |
JPS62298592A (ja) | 1987-12-25 |
FI872612A (fi) | 1987-12-14 |
DK300287A (da) | 1987-12-14 |
NO872462L (no) | 1987-12-14 |
EP0249224A3 (en) | 1989-01-25 |
CN87104167A (zh) | 1988-01-20 |
FI872612A0 (fi) | 1987-06-11 |
PT85071A (en) | 1987-07-01 |
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