ZA869054B - Production of cholecalciferol derivatives and novel intermediates used therefor - Google Patents
Production of cholecalciferol derivatives and novel intermediates used thereforInfo
- Publication number
- ZA869054B ZA869054B ZA869054A ZA869054A ZA869054B ZA 869054 B ZA869054 B ZA 869054B ZA 869054 A ZA869054 A ZA 869054A ZA 869054 A ZA869054 A ZA 869054A ZA 869054 B ZA869054 B ZA 869054B
- Authority
- ZA
- South Africa
- Prior art keywords
- production
- intermediates used
- novel intermediates
- used therefor
- cholecalciferol derivatives
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 150000003704 vitamin D3 derivatives Chemical class 0.000 title 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL77668A IL77668A (en) | 1986-01-21 | 1986-01-21 | Production of cholecalciferol derivatives and novel intermediates used therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA869054B true ZA869054B (en) | 1987-07-29 |
Family
ID=11056511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA869054A ZA869054B (en) | 1986-01-21 | 1986-12-01 | Production of cholecalciferol derivatives and novel intermediates used therefor |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4758382A (de) |
| EP (1) | EP0230600B1 (de) |
| JP (2) | JPS62169762A (de) |
| AT (1) | ATE54138T1 (de) |
| AU (1) | AU590644B2 (de) |
| DE (1) | DE3672251D1 (de) |
| IL (1) | IL77668A (de) |
| ZA (1) | ZA869054B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4927815A (en) * | 1988-04-29 | 1990-05-22 | Wisconsin Alumni Research Foundation | Compounds effective in inducing cell differentiation and process for preparing same |
| ATE124416T1 (de) * | 1988-07-05 | 1995-07-15 | Kuraray Co | Steroid-verbindungen. |
| GB9007236D0 (en) * | 1990-03-30 | 1990-05-30 | Leo Pharm Prod Ltd | Chemical compounds |
| AU650751B2 (en) * | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| DK0521550T3 (da) * | 1991-07-05 | 1996-11-04 | Duphar Int Res | Vitamin D forbindelse, fremgangsmåde til fremstilling af denne forbindelse og mellemprodukt derfor |
| JP2876547B2 (ja) * | 1992-06-23 | 1999-03-31 | 呉羽化学工業株式会社 | 抗クル病剤 |
| US5464866A (en) * | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| AU5018893A (en) * | 1992-08-17 | 1994-03-15 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| JP3306468B2 (ja) * | 1997-10-30 | 2002-07-24 | セレスティカ・ジャパン・イーエムエス株式会社 | 自動ハンダ付け機構及びその機構を用いる装置並びにそのハンダ付け方法 |
| PL188697B1 (pl) * | 1998-01-14 | 2005-03-31 | Inst Farmaceutyczny | Sposób otrzymywania pochodnych cholekalcyferolu oraz nowe związki pośrednie |
| JP4752110B2 (ja) * | 2000-12-25 | 2011-08-17 | 住友化学株式会社 | トリフルオロプロペニル化合物の製造法 |
| US9481646B2 (en) * | 2007-04-18 | 2016-11-01 | The Johns Hopkins University | Low calcemic, highly antiproliferative, analogs of calcitriol |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3715374A (en) * | 1972-05-05 | 1973-02-06 | Wisconsin Alumni Res Found | 24,25-dihydroxycholecalciferol |
| US4069321A (en) * | 1975-10-14 | 1978-01-17 | Merck & Co., Inc. | Blocked cholecalciferol and dihydrotachysterol 3 derivatives |
| JPS5735599A (en) * | 1980-08-05 | 1982-02-26 | Chugai Pharmaceut Co Ltd | 24,25-dihydroxycholestane and its preparation |
| US4442093A (en) * | 1981-05-15 | 1984-04-10 | Kureha Kagaku Kogyo Kabushiki Kaisha | Method for administering 24,25-dihydroxycholecalciferol to persons suffering from hypercalcemia |
| DE3471928D1 (en) * | 1983-01-28 | 1988-07-14 | Hoffmann La Roche | Process for the preparation of cholecalciferol derivatives |
| US4508651A (en) * | 1983-03-21 | 1985-04-02 | Hoffmann-La Roche Inc. | Synthesis of 1α,25-dihydroxyergocalciferol |
| IL74264A (en) * | 1984-02-08 | 1988-08-31 | Hoffmann La Roche | Preparation of calciferol derivatives,certain such novel compounds and pharmaceutical compositions containing them |
-
1986
- 1986-01-21 IL IL77668A patent/IL77668A/xx not_active IP Right Cessation
- 1986-12-01 ZA ZA869054A patent/ZA869054B/xx unknown
- 1986-12-02 AU AU66010/86A patent/AU590644B2/en not_active Ceased
- 1986-12-15 AT AT86117422T patent/ATE54138T1/de not_active IP Right Cessation
- 1986-12-15 DE DE8686117422T patent/DE3672251D1/de not_active Expired - Lifetime
- 1986-12-15 EP EP86117422A patent/EP0230600B1/de not_active Expired - Lifetime
- 1986-12-22 US US06/944,921 patent/US4758382A/en not_active Expired - Fee Related
-
1987
- 1987-01-20 JP JP62012153A patent/JPS62169762A/ja active Granted
-
1991
- 1991-11-01 JP JP3287990A patent/JP2505669B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0230600A1 (de) | 1987-08-05 |
| ATE54138T1 (de) | 1990-07-15 |
| EP0230600B1 (de) | 1990-06-27 |
| AU590644B2 (en) | 1989-11-09 |
| JPH0424346B2 (de) | 1992-04-24 |
| IL77668A (en) | 1989-03-31 |
| JPH054962A (ja) | 1993-01-14 |
| JPS62169762A (ja) | 1987-07-25 |
| US4758382A (en) | 1988-07-19 |
| AU6601086A (en) | 1987-07-23 |
| JP2505669B2 (ja) | 1996-06-12 |
| DE3672251D1 (de) | 1990-08-02 |
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