ZA854832B - Potent thymopentin analogs - Google Patents
Potent thymopentin analogsInfo
- Publication number
- ZA854832B ZA854832B ZA854832A ZA854832A ZA854832B ZA 854832 B ZA854832 B ZA 854832B ZA 854832 A ZA854832 A ZA 854832A ZA 854832 A ZA854832 A ZA 854832A ZA 854832 B ZA854832 B ZA 854832B
- Authority
- ZA
- South Africa
- Prior art keywords
- potent
- thymopentin
- analogs
- thymopentin analogs
- splenin
- Prior art date
Links
- 230000003389 potentiating effect Effects 0.000 title abstract 2
- PSWFFKRAVBDQEG-YGQNSOCVSA-N thymopentin Chemical class NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 PSWFFKRAVBDQEG-YGQNSOCVSA-N 0.000 title abstract 2
- 101710195641 Splenin Proteins 0.000 abstract 1
- 102400000160 Thymopentin Human genes 0.000 abstract 1
- 101800001703 Thymopentin Proteins 0.000 abstract 1
- 102400000159 Thymopoietin Human genes 0.000 abstract 1
- MLKWIQODPVLVLN-SHVFRELUSA-N ac1q1oa8 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CN)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C1=CC=C(O)C=C1 MLKWIQODPVLVLN-SHVFRELUSA-N 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000002992 thymic effect Effects 0.000 abstract 1
- 229960004517 thymopentin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
- C07K14/662—Thymopoietins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/18—Thymus derived hormone or factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Control Of Eletrric Generators (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Control Of Combustion (AREA)
- Control Of Charge By Means Of Generators (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/625,344 US4629723A (en) | 1984-06-27 | 1984-06-27 | Potent thymopentin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA854832B true ZA854832B (en) | 1987-02-25 |
Family
ID=24505633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA854832A ZA854832B (en) | 1984-06-27 | 1985-06-26 | Potent thymopentin analogs |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US4629723A (ja) |
| EP (1) | EP0166612B1 (ja) |
| JP (1) | JPH0689029B2 (ja) |
| KR (1) | KR920006563B1 (ja) |
| AT (1) | ATE81135T1 (ja) |
| AU (1) | AU592309B2 (ja) |
| CA (1) | CA1269499A (ja) |
| DE (1) | DE3586697T2 (ja) |
| DK (1) | DK171238B1 (ja) |
| FI (1) | FI92325C (ja) |
| IL (1) | IL75637A (ja) |
| NO (1) | NO167924C (ja) |
| NZ (1) | NZ212461A (ja) |
| ZA (1) | ZA854832B (ja) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0215805A1 (en) * | 1985-01-18 | 1987-04-01 | MERCK PATENT GmbH | Immunoregulatory peptides |
| DE3619633A1 (de) * | 1986-06-11 | 1987-12-17 | Hoechst Ag | Peptide mit einfluss auf die diurese und natriurese, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| HUT46044A (en) * | 1986-11-21 | 1988-09-28 | Richter Gedeon Vegyeszet | Process for producing immunstimulant peptides inhibiting multiplication of leukaemic cells and pharmaceutics comprising same |
| IT1216908B (it) * | 1987-03-19 | 1990-03-14 | Eniricerche Spa | Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche. |
| HU199878B (en) * | 1987-06-19 | 1990-03-28 | Berlin Chemie Veb | Process for producing acylated splenopentynes and pharmaceutical compositions comprising such compounds as active ingredient |
| US5656601A (en) * | 1987-06-19 | 1997-08-12 | Berlin-Chemie Ag | Acylated splenopentins, methods for their synthesis and their use |
| RU2023448C1 (ru) * | 1987-07-30 | 1994-11-30 | Сентро Насьональ Де Биопрепарадос | Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в |
| WO1989009229A1 (en) * | 1988-03-31 | 1989-10-05 | Immunobiology Research Institute, Inc. | Treatment of hiv viremic patients with thymopentin |
| NZ229004A (en) * | 1988-05-19 | 1993-09-27 | Immunobiology Res Inst Inc | Tetrapeptides having t cell helper acitivity |
| US4943477A (en) * | 1988-09-27 | 1990-07-24 | Mitsubishi Rayon Co., Ltd. | Conductive sheet having electromagnetic interference shielding function |
| AU627781B2 (en) * | 1988-09-30 | 1992-09-03 | Immunobiology Research Institute, Inc. | Peptides having t cell suppressor activity |
| IT1227908B (it) * | 1988-12-23 | 1991-05-14 | Eniricerche S P A Milano Sclav | Nuovi analoghi retro-inversi della timopentina, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche |
| US5218089A (en) * | 1988-12-23 | 1993-06-08 | Sclavo S.P.A. | Retro-inverso analogues of thymopentin and the method for their synthesis |
| US5036050A (en) * | 1989-01-12 | 1991-07-30 | Immunobiology Research Institute, Inc. | Compositions containing thymopentin for topical treatment of skin disorders |
| JPH06506918A (ja) * | 1991-02-04 | 1994-08-04 | ジヨージ・ワシントン・ユニバーシテイ | インターロイキン−１の産生を促進しそして年令−関連性免疫応答を調整するペプチドｍｂ−４ |
| US5492894A (en) * | 1991-03-21 | 1996-02-20 | The Procter & Gamble Company | Compositions for treating wrinkles comprising a peptide |
| US5215964A (en) * | 1991-06-03 | 1993-06-01 | Immunobiology Research Institute, Inc. | Peptides useful in regulating the immune and nervous systems |
| US5952465A (en) * | 1993-04-23 | 1999-09-14 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site |
| AU6770794A (en) * | 1993-04-23 | 1994-11-21 | Herbert J. Evans | Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site |
| US6258550B1 (en) | 1993-04-23 | 2001-07-10 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site |
| US5965698A (en) * | 1993-04-23 | 1999-10-12 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site |
| US5928896A (en) * | 1993-04-23 | 1999-07-27 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site |
| US5639729A (en) * | 1993-08-26 | 1997-06-17 | Immunobiology Research Institute, Inc. | Tripeptides useful in immune and CNS therapy |
| US6084066A (en) * | 1993-10-29 | 2000-07-04 | Virginia Commonwealth University | Polypetides that include conformation-constraining groups which flank a protein-protein interaction site |
| FR2741076B1 (fr) | 1995-11-15 | 1998-01-30 | Rech De Pathologie Appliquee S | Conjugues peptidiques derives des hormones thymiques, leur utilisation a titre de medicament et compositions les contenant |
| CN101168560B (zh) * | 2006-10-23 | 2012-09-05 | 江苏正大天晴药业股份有限公司 | N-取代肽酰胺，其药物组合物与用途 |
| CN114177314B (zh) * | 2021-12-16 | 2023-07-21 | 江西中医药大学 | 胸腺五肽及其衍生物在制备肿瘤诊断和/或治疗试剂中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4077949A (en) * | 1973-12-28 | 1978-03-07 | Sloan-Kettering Institute For Cancer Research | Polypeptide hormones of the thymus |
| US4002740A (en) * | 1975-08-21 | 1977-01-11 | Gideon Goldstein | Tridecapeptide compositions and methods |
| US4190646A (en) * | 1975-11-11 | 1980-02-26 | Sloan-Kettering Institute For Cancer Research | Polypeptide compositions and methods |
| SE446867B (sv) * | 1977-11-15 | 1986-10-13 | Sloan Kettering Inst Cancer | Sett att framstella en polypeptid med formaga att inducera differentiering av t-lymfocyter men inte av komplementreceptor (cr?72+) b-lymfocyter |
| CA1157466A (en) * | 1979-04-12 | 1983-11-22 | Gideon Goldstein | Peptides having thymopoietin-like activity |
| ZA802170B (en) * | 1979-04-12 | 1981-11-25 | Ortho Pharma Corp | Peptides having thymopoietin-like activity |
| US4261886A (en) * | 1980-03-13 | 1981-04-14 | Ortho Pharmaceutical Corporation | Peptides having thymopoietin-like activity |
| DE2938420A1 (de) * | 1979-09-22 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Neue peptide und verfahren zu ihrer herstellung |
| US4309340A (en) * | 1980-03-31 | 1982-01-05 | American Home Products Corporation | Polypeptide compositions |
| US4361673A (en) * | 1980-09-19 | 1982-11-30 | American Home Products Corporation | Polypeptide compositions |
| US4305852A (en) * | 1980-10-20 | 1981-12-15 | American Home Products Corporation | Polypeptide compositions |
| US4505853A (en) * | 1983-11-18 | 1985-03-19 | Ortho Pharmaceutical Corporation | Enzyme-resistant immunomodulatory peptides |
| DE3421614A1 (de) * | 1984-06-09 | 1985-12-12 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens |
-
1984
- 1984-06-27 US US06/625,344 patent/US4629723A/en not_active Ceased
-
1985
- 1985-06-18 NZ NZ212461A patent/NZ212461A/xx unknown
- 1985-06-26 IL IL75637A patent/IL75637A/xx not_active IP Right Cessation
- 1985-06-26 CA CA000485260A patent/CA1269499A/en not_active Expired - Lifetime
- 1985-06-26 AT AT85304559T patent/ATE81135T1/de not_active IP Right Cessation
- 1985-06-26 DE DE8585304559T patent/DE3586697T2/de not_active Expired - Lifetime
- 1985-06-26 DK DK289285A patent/DK171238B1/da not_active IP Right Cessation
- 1985-06-26 EP EP85304559A patent/EP0166612B1/en not_active Expired - Lifetime
- 1985-06-26 AU AU44215/85A patent/AU592309B2/en not_active Expired
- 1985-06-26 NO NO852567A patent/NO167924C/no unknown
- 1985-06-26 FI FI852522A patent/FI92325C/fi not_active IP Right Cessation
- 1985-06-26 KR KR1019850004553A patent/KR920006563B1/ko not_active IP Right Cessation
- 1985-06-26 ZA ZA854832A patent/ZA854832B/xx unknown
- 1985-06-27 JP JP60141464A patent/JPH0689029B2/ja not_active Expired - Lifetime
-
1990
- 1990-04-25 US US07/514,184 patent/USRE34165E/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6118799A (ja) | 1986-01-27 |
| IL75637A (en) | 1990-02-09 |
| JPH0689029B2 (ja) | 1994-11-09 |
| EP0166612A3 (en) | 1987-08-05 |
| DK171238B1 (da) | 1996-08-05 |
| NO167924B (no) | 1991-09-16 |
| CA1269499A (en) | 1990-05-22 |
| IL75637A0 (en) | 1985-10-31 |
| DK289285D0 (da) | 1985-06-26 |
| US4629723A (en) | 1986-12-16 |
| EP0166612A2 (en) | 1986-01-02 |
| DK289285A (da) | 1985-12-28 |
| FI852522L (fi) | 1985-12-28 |
| KR920006563B1 (ko) | 1992-08-08 |
| USRE34165E (en) | 1993-01-19 |
| FI92325B (fi) | 1994-07-15 |
| EP0166612B1 (en) | 1992-09-30 |
| DE3586697D1 (en) | 1992-11-05 |
| FI852522A0 (fi) | 1985-06-26 |
| NZ212461A (en) | 1988-10-28 |
| AU592309B2 (en) | 1990-01-11 |
| ATE81135T1 (de) | 1992-10-15 |
| NO167924C (no) | 1991-12-27 |
| NO852567L (no) | 1985-12-30 |
| KR860000314A (ko) | 1986-01-28 |
| FI92325C (fi) | 1994-10-25 |
| AU4421585A (en) | 1986-01-02 |
| DE3586697T2 (de) | 1993-02-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0166612A3 (en) | Potent thymopentin analogs | |
| EP0165033A3 (en) | Conformationally restricted thymopentin-like compounds | |
| ES8607732A1 (es) | Procedimiento para producir un preparado implantable de un peptido regulador, uno de sus analogos o una de sus sales fisiologicamente compatibles. | |
| MY103189A (en) | Nor-statine and nor-cyclostatine polypeptides | |
| EG18454A (en) | Enzymatic membrane method for the synthesis and separation of peptides. | |
| IT8421622A0 (it) | Procedimento per la preparazione di peptidi. | |
| MY102046A (en) | Compartmentalized transdermal delivery system. | |
| AU566133B2 (en) | New polypeptide from thymus glands | |
| MY128260A (en) | Cyclopentane-and-pentene-b-amino acids | |
| AU3539484A (en) | Novel peptides which are active on the central nervous system and have an action on the cholinergic system | |
| EP0219082A3 (en) | Process for preparing halogen-magnesium alanate, and its use | |
| IT8567535A1 (it) | Procedimento per la preparazione di amminoidrossicefamcarbossilati. | |
| EP0179412A3 (en) | Antigenic peptide compounds | |
| ES8505642A1 (es) | Un procedimiento para preparar fenilanilinas-n.sustituidas. | |
| ES8502611A1 (es) | Un procedimiento para preparar composiciones farmaceuticas a base de sales de teofilina y aminoacidos basicos | |
| EP0220157A3 (en) | Mitogenic peptides | |
| ES8609301A1 (es) | Procedimiento para la obtencion de 3-metil-7-fluor-5-nitro- benzotiofeno | |
| HUT58415A (en) | Apparatus for creating permanent deformation on the surface of leathers preferably upper leathers, amid dynamic circumstances | |
| SU1111454A1 (ru) | Способ получения (4,6-дизамещенный пиримидинил-2)тиофанийбромидов | |
| UA7130A1 (uk) | Імуностимулюючий засіб "тімоген" | |
| SU1216944A1 (ru) | Способ получения 2,6-ди-трет-бутилфенола | |
| BG41624A1 (en) | System for regulating productivity of coal vapour generator | |
| BG40657A3 (en) | Method for preparing derivatives of a- 21978c cyclic peptides | |
| PL265911A1 (en) | System for series stabilizing of d.c. voltage |