DE3586697T2 - Aktive thymopentin-analoga. - Google Patents

Aktive thymopentin-analoga.

Info

Publication number
DE3586697T2
DE3586697T2 DE8585304559T DE3586697T DE3586697T2 DE 3586697 T2 DE3586697 T2 DE 3586697T2 DE 8585304559 T DE8585304559 T DE 8585304559T DE 3586697 T DE3586697 T DE 3586697T DE 3586697 T2 DE3586697 T2 DE 3586697T2
Authority
DE
Germany
Prior art keywords
thymopentin
analog
active
splenin
immunoregulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585304559T
Other languages
English (en)
Other versions
DE3586697D1 (en
Inventor
Gideon Goldstein
George Heavner
Daniel Kroon
Tapan Audhya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of DE3586697D1 publication Critical patent/DE3586697D1/de
Application granted granted Critical
Publication of DE3586697T2 publication Critical patent/DE3586697T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/66—Thymopoietins
    • C07K14/662—Thymopoietins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/18—Thymus derived hormone or factor; related peptides
DE8585304559T 1984-06-27 1985-06-26 Aktive thymopentin-analoga. Expired - Lifetime DE3586697T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/625,344 US4629723A (en) 1984-06-27 1984-06-27 Potent thymopentin analogs

Publications (2)

Publication Number Publication Date
DE3586697D1 DE3586697D1 (en) 1992-11-05
DE3586697T2 true DE3586697T2 (de) 1993-02-11

Family

ID=24505633

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585304559T Expired - Lifetime DE3586697T2 (de) 1984-06-27 1985-06-26 Aktive thymopentin-analoga.

Country Status (14)

Country Link
US (2) US4629723A (de)
EP (1) EP0166612B1 (de)
JP (1) JPH0689029B2 (de)
KR (1) KR920006563B1 (de)
AT (1) ATE81135T1 (de)
AU (1) AU592309B2 (de)
CA (1) CA1269499A (de)
DE (1) DE3586697T2 (de)
DK (1) DK171238B1 (de)
FI (1) FI92325C (de)
IL (1) IL75637A (de)
NO (1) NO167924C (de)
NZ (1) NZ212461A (de)
ZA (1) ZA854832B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215805A1 (de) * 1985-01-18 1987-04-01 MERCK PATENT GmbH Immunoregulatorische peptide
DE3619633A1 (de) * 1986-06-11 1987-12-17 Hoechst Ag Peptide mit einfluss auf die diurese und natriurese, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
HUT46044A (en) * 1986-11-21 1988-09-28 Richter Gedeon Vegyeszet Process for producing immunstimulant peptides inhibiting multiplication of leukaemic cells and pharmaceutics comprising same
IT1216908B (it) * 1987-03-19 1990-03-14 Eniricerche Spa Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.
US5656601A (en) * 1987-06-19 1997-08-12 Berlin-Chemie Ag Acylated splenopentins, methods for their synthesis and their use
HU199878B (en) * 1987-06-19 1990-03-28 Berlin Chemie Veb Process for producing acylated splenopentynes and pharmaceutical compositions comprising such compounds as active ingredient
RU2023448C1 (ru) * 1987-07-30 1994-11-30 Сентро Насьональ Де Биопрепарадос Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в
WO1989009229A1 (en) * 1988-03-31 1989-10-05 Immunobiology Research Institute, Inc. Treatment of hiv viremic patients with thymopentin
NZ229004A (en) 1988-05-19 1993-09-27 Immunobiology Res Inst Inc Tetrapeptides having t cell helper acitivity
US4943477A (en) * 1988-09-27 1990-07-24 Mitsubishi Rayon Co., Ltd. Conductive sheet having electromagnetic interference shielding function
HU205143B (en) * 1988-09-30 1992-03-30 Immunobiology Res Inst Inc Process for producing peptides having t cell suppressor activity and pharmaceutical compositions comprising same
US5218089A (en) * 1988-12-23 1993-06-08 Sclavo S.P.A. Retro-inverso analogues of thymopentin and the method for their synthesis
IT1227908B (it) * 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Nuovi analoghi retro-inversi della timopentina, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche
US5036050A (en) * 1989-01-12 1991-07-30 Immunobiology Research Institute, Inc. Compositions containing thymopentin for topical treatment of skin disorders
JPH06506918A (ja) * 1991-02-04 1994-08-04 ジヨージ・ワシントン・ユニバーシテイ インターロイキン−１の産生を促進しそして年令−関連性免疫応答を調整するペプチドｍｂ−４
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
US5215964A (en) * 1991-06-03 1993-06-01 Immunobiology Research Institute, Inc. Peptides useful in regulating the immune and nervous systems
US6258550B1 (en) 1993-04-23 2001-07-10 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5952465A (en) * 1993-04-23 1999-09-14 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5965698A (en) * 1993-04-23 1999-10-12 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US5928896A (en) * 1993-04-23 1999-07-27 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
WO1994025482A1 (en) * 1993-04-23 1994-11-10 Evans Herbert J Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5639729A (en) * 1993-08-26 1997-06-17 Immunobiology Research Institute, Inc. Tripeptides useful in immune and CNS therapy
US6084066A (en) * 1993-10-29 2000-07-04 Virginia Commonwealth University Polypetides that include conformation-constraining groups which flank a protein-protein interaction site
FR2741076B1 (fr) * 1995-11-15 1998-01-30 Rech De Pathologie Appliquee S Conjugues peptidiques derives des hormones thymiques, leur utilisation a titre de medicament et compositions les contenant
CN101168560B (zh) * 2006-10-23 2012-09-05 江苏正大天晴药业股份有限公司 N-取代肽酰胺，其药物组合物与用途
CN117860921A (zh) * 2021-12-16 2024-04-12 江西中医药大学 一种胸腺五肽衍生物tp-7在制备肿瘤诊断和/或治疗试剂中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077949A (en) * 1973-12-28 1978-03-07 Sloan-Kettering Institute For Cancer Research Polypeptide hormones of the thymus
US4002740A (en) * 1975-08-21 1977-01-11 Gideon Goldstein Tridecapeptide compositions and methods
US4190646A (en) * 1975-11-11 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptide compositions and methods
SE446867B (sv) * 1977-11-15 1986-10-13 Sloan Kettering Inst Cancer Sett att framstella en polypeptid med formaga att inducera differentiering av t-lymfocyter men inte av komplementreceptor (cr?72+) b-lymfocyter
ZA802170B (en) * 1979-04-12 1981-11-25 Ortho Pharma Corp Peptides having thymopoietin-like activity
US4261886A (en) * 1980-03-13 1981-04-14 Ortho Pharmaceutical Corporation Peptides having thymopoietin-like activity
CA1157466A (en) * 1979-04-12 1983-11-22 Gideon Goldstein Peptides having thymopoietin-like activity
DE2938420A1 (de) * 1979-09-22 1981-04-09 Hoechst Ag, 6000 Frankfurt Neue peptide und verfahren zu ihrer herstellung
US4309340A (en) * 1980-03-31 1982-01-05 American Home Products Corporation Polypeptide compositions
US4361673A (en) * 1980-09-19 1982-11-30 American Home Products Corporation Polypeptide compositions
US4305852A (en) * 1980-10-20 1981-12-15 American Home Products Corporation Polypeptide compositions
US4505853A (en) * 1983-11-18 1985-03-19 Ortho Pharmaceutical Corporation Enzyme-resistant immunomodulatory peptides
DE3421614A1 (de) * 1984-06-09 1985-12-12 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens

Also Published As

Publication number Publication date
EP0166612A3 (en) 1987-08-05
NO167924C (no) 1991-12-27
USRE34165E (en) 1993-01-19
IL75637A0 (en) 1985-10-31
DK171238B1 (da) 1996-08-05
NO852567L (no) 1985-12-30
FI92325C (fi) 1994-10-25
NZ212461A (en) 1988-10-28
DK289285A (da) 1985-12-28
JPH0689029B2 (ja) 1994-11-09
AU592309B2 (en) 1990-01-11
EP0166612A2 (de) 1986-01-02
AU4421585A (en) 1986-01-02
US4629723A (en) 1986-12-16
KR860000314A (ko) 1986-01-28
JPS6118799A (ja) 1986-01-27
ATE81135T1 (de) 1992-10-15
FI852522L (fi) 1985-12-28
KR920006563B1 (ko) 1992-08-08
FI852522A0 (fi) 1985-06-26
ZA854832B (en) 1987-02-25
DK289285D0 (da) 1985-06-26
EP0166612B1 (de) 1992-09-30
DE3586697D1 (en) 1992-11-05
CA1269499A (en) 1990-05-22
FI92325B (fi) 1994-07-15
IL75637A (en) 1990-02-09
NO167924B (no) 1991-09-16

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