ZA854683B - New 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidines,their preparation and pharmaceutical compositions containing these compounds - Google Patents
New 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidines,their preparation and pharmaceutical compositions containing these compoundsInfo
- Publication number
- ZA854683B ZA854683B ZA854683A ZA854683A ZA854683B ZA 854683 B ZA854683 B ZA 854683B ZA 854683 A ZA854683 A ZA 854683A ZA 854683 A ZA854683 A ZA 854683A ZA 854683 B ZA854683 B ZA 854683B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- compounds
- acid addition
- addition salts
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843423092 DE3423092A1 (de) | 1984-06-22 | 1984-06-22 | Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA854683B true ZA854683B (en) | 1987-02-25 |
Family
ID=6238919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA854683A ZA854683B (en) | 1984-06-22 | 1985-06-21 | New 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidines,their preparation and pharmaceutical compositions containing these compounds |
Country Status (19)
Country | Link |
---|---|
US (1) | US4714698A (es) |
EP (1) | EP0167817B1 (es) |
JP (1) | JPH0694465B2 (es) |
KR (1) | KR920007435B1 (es) |
AT (1) | ATE46511T1 (es) |
AU (1) | AU579869B2 (es) |
CA (1) | CA1241325A (es) |
DE (2) | DE3423092A1 (es) |
DK (1) | DK282285A (es) |
ES (1) | ES8604590A1 (es) |
FI (1) | FI80455C (es) |
GR (1) | GR851467B (es) |
IE (1) | IE58432B1 (es) |
IL (1) | IL75596A0 (es) |
NO (1) | NO161620C (es) |
NZ (1) | NZ212515A (es) |
PH (1) | PH21319A (es) |
PT (1) | PT80670B (es) |
ZA (1) | ZA854683B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH075594B2 (ja) * | 1986-03-25 | 1995-01-25 | 三井石油化学工業株式会社 | 新規ピリドピリミジン誘導体 |
GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
US4885300A (en) * | 1988-03-03 | 1989-12-05 | Ortho Pharmaceutical Corporation | 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives |
DE4325900A1 (de) * | 1993-08-02 | 1995-02-09 | Thomae Gmbh Dr K | Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
DE19608653A1 (de) * | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
EP1660092A2 (en) | 2003-07-03 | 2006-05-31 | Myriad Genetics, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
ATE549338T1 (de) * | 2006-05-24 | 2012-03-15 | Boehringer Ingelheim Int | Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1116676B (de) * | 1955-03-14 | 1961-11-09 | Thomae Gmbh Dr K | Verfahren zur Herstellung von Pyrimido [5, 4-d] pyrimidinen |
US3031450A (en) * | 1959-04-30 | 1962-04-24 | Thomae Gmbh Dr K | Substituted pyrimido-[5, 4-d]-pyrimidines |
US3322755A (en) * | 1964-03-10 | 1967-05-30 | Boehringer Sohn Ingelheim | Basic-substituted 1, 2, 3, 4-tetrahydropyrimido [5, 4-d]-pyrimidines |
GB1190419A (en) * | 1966-08-16 | 1970-05-06 | Yamanouchi Pharma Co Ltd | Substituted Pyrimido-Pyrimidines and a process for the preparation thereof |
DE3069211D1 (en) * | 1979-07-03 | 1984-10-25 | Thomae Gmbh Dr K | 2-(perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them |
DE2926804A1 (de) * | 1979-07-03 | 1981-01-22 | Thomae Gmbh Dr K | Neue 2-(perhydro-1,4-diazino)-pyrimido- eckige klammer auf 5,4-d eckige klammer zu pyrimidine, deren herstellung und verwendung als arzneimittel |
DE3049207A1 (de) * | 1980-12-27 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel |
-
1984
- 1984-06-22 DE DE19843423092 patent/DE3423092A1/de not_active Withdrawn
-
1985
- 1985-06-04 EP EP85106900A patent/EP0167817B1/de not_active Expired
- 1985-06-04 AT AT85106900T patent/ATE46511T1/de not_active IP Right Cessation
- 1985-06-04 DE DE8585106900T patent/DE3573119D1/de not_active Expired
- 1985-06-17 GR GR851467A patent/GR851467B/el unknown
- 1985-06-17 US US06/745,095 patent/US4714698A/en not_active Expired - Fee Related
- 1985-06-20 FI FI852445A patent/FI80455C/fi not_active IP Right Cessation
- 1985-06-20 PT PT80670A patent/PT80670B/pt not_active IP Right Cessation
- 1985-06-21 IE IE154585A patent/IE58432B1/en not_active IP Right Cessation
- 1985-06-21 JP JP60135820A patent/JPH0694465B2/ja not_active Expired - Lifetime
- 1985-06-21 NO NO852514A patent/NO161620C/no unknown
- 1985-06-21 AU AU43968/85A patent/AU579869B2/en not_active Ceased
- 1985-06-21 IL IL75596A patent/IL75596A0/xx not_active IP Right Cessation
- 1985-06-21 KR KR1019850004411A patent/KR920007435B1/ko not_active IP Right Cessation
- 1985-06-21 CA CA000484743A patent/CA1241325A/en not_active Expired
- 1985-06-21 NZ NZ212515A patent/NZ212515A/xx unknown
- 1985-06-21 DK DK282285A patent/DK282285A/da not_active Application Discontinuation
- 1985-06-21 ZA ZA854683A patent/ZA854683B/xx unknown
- 1985-06-21 ES ES544417A patent/ES8604590A1/es not_active Expired
- 1985-06-21 PH PH32439A patent/PH21319A/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES8604590A1 (es) | 1986-02-01 |
IE58432B1 (en) | 1993-09-22 |
ATE46511T1 (de) | 1989-10-15 |
JPH0694465B2 (ja) | 1994-11-24 |
FI852445L (fi) | 1985-12-23 |
IL75596A0 (en) | 1985-10-31 |
DK282285D0 (da) | 1985-06-21 |
PT80670B (de) | 1987-05-08 |
NZ212515A (en) | 1988-10-28 |
CA1241325A (en) | 1988-08-30 |
NO161620C (no) | 1989-09-06 |
KR860000287A (ko) | 1986-01-27 |
JPS6115883A (ja) | 1986-01-23 |
KR920007435B1 (ko) | 1992-09-01 |
ES544417A0 (es) | 1986-02-01 |
NO161620B (no) | 1989-05-29 |
EP0167817B1 (de) | 1989-09-20 |
GR851467B (es) | 1985-11-25 |
PT80670A (de) | 1985-07-01 |
US4714698A (en) | 1987-12-22 |
FI80455C (fi) | 1990-06-11 |
DE3573119D1 (en) | 1989-10-26 |
NO852514L (no) | 1985-12-23 |
DE3423092A1 (de) | 1986-01-02 |
FI852445A0 (fi) | 1985-06-20 |
IE851545L (en) | 1985-12-22 |
FI80455B (fi) | 1990-02-28 |
PH21319A (en) | 1987-09-28 |
DK282285A (da) | 1985-12-23 |
AU579869B2 (en) | 1988-12-15 |
AU4396885A (en) | 1986-01-02 |
EP0167817A1 (de) | 1986-01-15 |
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