ZA852557B - Novel monoclonal antibodies and hybridoma cells,processes for their preparation and their applications - Google Patents

Novel monoclonal antibodies and hybridoma cells,processes for their preparation and their applications

Info

Publication number
ZA852557B
ZA852557B ZA852557A ZA852557A ZA852557B ZA 852557 B ZA852557 B ZA 852557B ZA 852557 A ZA852557 A ZA 852557A ZA 852557 A ZA852557 A ZA 852557A ZA 852557 B ZA852557 B ZA 852557B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
monoclonal antibodies
hybridoma cells
applications
Prior art date
Application number
ZA852557A
Other languages
English (en)
Inventor
Christoph Heusser
Rudolf Heinrich Andreatta
Sefik Alkan
Jeanette Wood
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of ZA852557B publication Critical patent/ZA852557B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
ZA852557A 1984-04-09 1985-04-04 Novel monoclonal antibodies and hybridoma cells,processes for their preparation and their applications ZA852557B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH178184 1984-04-09

Publications (1)

Publication Number Publication Date
ZA852557B true ZA852557B (en) 1985-11-27

Family

ID=4218460

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA852557A ZA852557B (en) 1984-04-09 1985-04-04 Novel monoclonal antibodies and hybridoma cells,processes for their preparation and their applications

Country Status (13)

Country Link
US (1) US4780401A (fr)
EP (1) EP0158599B1 (fr)
JP (2) JPH0669390B2 (fr)
AT (1) ATE57392T1 (fr)
AU (1) AU591870B2 (fr)
CA (1) CA1277261C (fr)
DE (1) DE3580056D1 (fr)
DK (1) DK165326C (fr)
ES (2) ES8707295A1 (fr)
FI (1) FI87933C (fr)
IE (1) IE57956B1 (fr)
NO (1) NO165556C (fr)
ZA (1) ZA852557B (fr)

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US5972990A (en) * 1992-04-10 1999-10-26 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
WO1993023433A1 (fr) * 1992-05-14 1993-11-25 L.R.S. Diagnostics, Inc. Procedes et nouvelles proteines associes au syndrome de renine basse
DE69322847T2 (de) * 1993-01-13 1999-05-27 Idemitsu Kosan Co. Ltd., Tokio/Tokyo Monoklonaler Antikörper gegen menschliches Ceruloplasmin
WO1994020857A1 (fr) * 1993-03-11 1994-09-15 The Regents Of The University Of California Titrage s'appliquant a l'immunite humorale par rapport a des macromolecules
US6911528B1 (en) * 1994-12-02 2005-06-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US20030167483A1 (en) * 1998-06-24 2003-09-04 Farese Robert V. Diacylglycerol O-acyltransferase
CA2427271A1 (fr) 2000-12-14 2002-06-20 Brigham And Women's Hospital, Inc. Marqueurs inflammatoires pour la detection et la prevention du diabete sucre
DK2336359T3 (en) 2002-05-09 2016-05-30 Brigham & Womens Hospital 1L1RL-1 as cardiovascular disease marker
WO2003095623A2 (fr) * 2002-05-10 2003-11-20 The Trustees Of Columbia University In The City Of New York Lignees cellulaires et systemes mis au point par genie genetique et destines a propager le virus varicelle-zona, et methodes d'utilisation associees
US20070010571A1 (en) * 2003-08-20 2007-01-11 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
WO2005023183A2 (fr) * 2003-08-28 2005-03-17 Nitromed, Inc. Composes diuretiques nitroses et nitrosyles, compositions et procedes d'utilisation correspondants
JP2007504171A (ja) 2003-08-29 2007-03-01 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド 細胞壊死インヒビター
EP2306192B1 (fr) 2003-12-05 2015-10-14 The Cleveland Clinic Foundation Marqueurs de risque pour maladies cardiovasculaires
AU2005207037A1 (en) * 2004-01-22 2005-08-04 Nitromed, Inc. Nitrosated and/or nitrosylated compounds, compositions and methods of use
US7803838B2 (en) * 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
WO2006041855A2 (fr) 2004-10-04 2006-04-20 Nitromed, Inc. Compositions et procedes faisant intervenir des composes apocynine et des donneurs d'oxyde nitrique
ES2439229T3 (es) 2004-10-06 2014-01-22 The Brigham And Women's Hospital, Inc. Relevancia de niveles logrados de marcadores de inflamación sistémica tras el tratamiento
JP2008520578A (ja) * 2004-11-15 2008-06-19 ニトロメッド インコーポレーティッド 複素環式の酸化窒素供与体基を含む利尿化合物、組成物および使用方法
EP1846380A4 (fr) * 2005-01-21 2010-02-17 Nicox Sa Compositions de groupes donneurs a base de monoxyde d'azote heterocyclique contenant des composes cardio-vasculaires, et methodes permettant de les utiliser
NZ560386A (en) * 2005-01-31 2009-12-24 Mylan Lab Inc Pharmaceutical composition comprising hydroxylated nebivolol
WO2007086884A2 (fr) * 2005-02-16 2007-08-02 Nitromed, Inc. Sels donneurs d’oxyde nitrique organique de composes antimicrobiens et composes et procedes d’utilisation
US20090012057A1 (en) * 2005-02-28 2009-01-08 Nitromed, Inc. Cardiovascular Compounds Comprising Nitric Oxide Enhancing Groups, Compositions and Methods of Use
US20090215838A1 (en) * 2005-03-09 2009-08-27 Nitromed, Inc. Organic nitric oxide enhancing salts of angiotensin ii antagonists, compositions and methods of use
AP2896A (en) 2005-05-31 2014-05-31 Mylan Lab Inc Compositions comprising nebivolol
US20090018091A1 (en) * 2005-08-02 2009-01-15 Nitromed, Inc. Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use
WO2007041681A2 (fr) * 2005-10-04 2007-04-12 Nitromed, Inc. Méthodes de traitement de troubles respiratoires
US8119358B2 (en) 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
WO2007059311A2 (fr) * 2005-11-16 2007-05-24 Nitromed, Inc. Composes furoxane, compositions et procedes d’utilisation
EP1968584A2 (fr) * 2005-12-20 2008-09-17 Nitromed, Inc. Composes a l'acide glutamique activateurs d'oxyde nitrique, compositions et procedes d'utilisation
WO2007075542A2 (fr) * 2005-12-22 2007-07-05 Nitromed, Inc. Composes au pyruvate activateurs d'oxyde nitrique, compositions et procedes d'utilisation
WO2007146229A2 (fr) 2006-06-07 2007-12-21 Tethys Bioscience, Inc. Marqueurs associés à des événements artério-vasculaires et procédés d'utilisation de ces marqueurs
US7897360B2 (en) * 2006-12-15 2011-03-01 Kimberly-Clark Worldwide, Inc. Enzyme detection techniques
CN102317786A (zh) 2007-04-18 2012-01-11 特提斯生物科学公司 糖尿病相关性生物学标记物及其使用方法
US7828840B2 (en) * 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
GB2462022B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof
EP2531163A1 (fr) 2010-02-01 2012-12-12 The Hospital For Sick Children Conditionnement ischémique à distance pour traiter et prévenir la resténose
KR20130040851A (ko) 2010-03-31 2013-04-24 더 호스피탈 포 식 칠드런 심근 경색 후 결과를 개선시키기 위한 원격 허혈 처치의 사용
AU2013259294B2 (en) 2012-05-11 2017-04-06 Synchronicity Pharma, Inc. Carbazole-containing sulfonamides as cryptochrome modulators
WO2014022195A1 (fr) 2012-08-01 2014-02-06 Tavakoli Zahra Compositions congelées à écoulement libre comprenant un agent thérapeutique
US9725452B2 (en) 2013-03-15 2017-08-08 Presidents And Fellows Of Harvard College Substituted indoles and pyrroles as RIP kinase inhibitors
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
JP6836748B2 (ja) * 2016-10-21 2021-03-03 富士レビオ株式会社 レニン濃度の免疫学的測定法
CN107007849A (zh) * 2017-06-19 2017-08-04 河北省人民医院 一种建立甲减性心功能不全大鼠动物模型的方法

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Also Published As

Publication number Publication date
ATE57392T1 (de) 1990-10-15
NO851384L (no) 1985-10-10
ES8707295A1 (es) 1987-07-16
EP0158599A2 (fr) 1985-10-16
IE57956B1 (en) 1993-05-19
AU4088685A (en) 1985-10-17
FI851334L (fi) 1985-10-10
AU591870B2 (en) 1989-12-21
DK165326B (da) 1992-11-09
DK153385D0 (da) 1985-04-03
NO165556B (no) 1990-11-19
DE3580056D1 (de) 1990-11-15
FI87933B (fi) 1992-11-30
US4780401A (en) 1988-10-25
ES8802254A1 (es) 1988-04-16
NO165556C (no) 1991-02-27
FI87933C (fi) 1993-03-10
ES557016A0 (es) 1988-04-16
IE850876L (en) 1985-10-09
FI851334A0 (fi) 1985-04-03
DK165326C (da) 1993-03-29
EP0158599B1 (fr) 1990-10-10
JPS60231624A (ja) 1985-11-18
CA1277261C (fr) 1990-12-04
JPH0669371B2 (ja) 1994-09-07
EP0158599A3 (en) 1987-12-16
DK153385A (da) 1985-10-10
JPH0669390B2 (ja) 1994-09-07
ES542017A0 (es) 1987-07-16
JPS6485070A (en) 1989-03-30

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