ES557016A0 - Procedimiento para la obtencion de celulas de hibridona que disocian anticuerpos monoclonales con elevada afinidad a la renina humana. - Google Patents
Procedimiento para la obtencion de celulas de hibridona que disocian anticuerpos monoclonales con elevada afinidad a la renina humana.Info
- Publication number
- ES557016A0 ES557016A0 ES557016A ES557016A ES557016A0 ES 557016 A0 ES557016 A0 ES 557016A0 ES 557016 A ES557016 A ES 557016A ES 557016 A ES557016 A ES 557016A ES 557016 A0 ES557016 A0 ES 557016A0
- Authority
- ES
- Spain
- Prior art keywords
- human
- monoclonal antibodies
- high affinity
- hybridone
- disounce
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH178184 | 1984-04-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8802254A1 ES8802254A1 (es) | 1988-04-16 |
ES557016A0 true ES557016A0 (es) | 1988-04-16 |
Family
ID=4218460
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542017A Expired ES8707295A1 (es) | 1984-04-09 | 1985-04-08 | Procedimiento para la obtencion de anticuerpos monoclonales |
ES557016A Expired ES8802254A1 (es) | 1984-04-09 | 1986-08-14 | Procedimiento para la obtencion de celulas de hibridona que disocian anticuerpos monoclonales con elevada afinidad a la renina humana. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542017A Expired ES8707295A1 (es) | 1984-04-09 | 1985-04-08 | Procedimiento para la obtencion de anticuerpos monoclonales |
Country Status (13)
Country | Link |
---|---|
US (1) | US4780401A (es) |
EP (1) | EP0158599B1 (es) |
JP (2) | JPH0669390B2 (es) |
AT (1) | ATE57392T1 (es) |
AU (1) | AU591870B2 (es) |
CA (1) | CA1277261C (es) |
DE (1) | DE3580056D1 (es) |
DK (1) | DK165326C (es) |
ES (2) | ES8707295A1 (es) |
FI (1) | FI87933C (es) |
IE (1) | IE57956B1 (es) |
NO (1) | NO165556C (es) |
ZA (1) | ZA852557B (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5972990A (en) * | 1992-04-10 | 1999-10-26 | Brigham And Women's Hospital, Inc. | Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims |
WO1993023433A1 (en) * | 1992-05-14 | 1993-11-25 | L.R.S. Diagnostics, Inc. | Methods and novel proteins associated with low renin syndrome |
DE606516T1 (de) * | 1993-01-13 | 1995-03-16 | Idemitsu Kosan Co | Gegen menschlichen Ceruloplasmin monoklonaler Antikörper. |
WO1994020857A1 (en) * | 1993-03-11 | 1994-09-15 | The Regents Of The University Of California | Assay for humoral immunity to macromolecules |
US6911528B1 (en) * | 1994-12-02 | 2005-06-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
US20030167483A1 (en) * | 1998-06-24 | 2003-09-04 | Farese Robert V. | Diacylglycerol O-acyltransferase |
WO2002048715A2 (en) | 2000-12-14 | 2002-06-20 | The Brigham And Women's Hospital, Inc. | Inflammatory markers for detection and prevention of diabetes mellitus |
ATE534747T1 (de) | 2002-05-09 | 2011-12-15 | Brigham & Womens Hospital | 1l1rl-1 als marker für kardiovaskuläre erkrankungen |
US7273616B2 (en) * | 2002-05-10 | 2007-09-25 | The Trustees Of Columbia University In The City Of New York | Genetically engineered cell lines and systems for propagating Varicella zoster virus and methods of use thereof |
JP2007502831A (ja) * | 2003-08-20 | 2007-02-15 | ニトロメッド インコーポレーティッド | ニトロソ化およびニトロシル化心血管化合物、組成物、ならびに使用方法 |
EP1668008A4 (en) * | 2003-08-28 | 2009-02-25 | Nitromed Inc | NITROSED AND NITROSYLATED DIETETIC COMPOUNDS, COMPOSITIONS AND APPLICATION METHODS |
HUE027546T2 (en) | 2003-08-29 | 2016-10-28 | Brigham & Womens Hospital Inc | Hydantoin derivatives as cell necrosis inhibitors |
US7781219B2 (en) | 2003-12-05 | 2010-08-24 | The Cleveland Clinic Foundation | Risk markers for cardiovascular disease |
EP1718286A4 (en) * | 2004-01-22 | 2010-03-31 | Nicox Sa | NITROSIS AND / OR NITROSYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF |
US7803838B2 (en) * | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
WO2006041855A2 (en) | 2004-10-04 | 2006-04-20 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
US9164104B2 (en) | 2004-10-06 | 2015-10-20 | The Brigham And Women's Hospital, Inc. | Relevance of achieved levels of markers of systemic inflammation following treatment |
WO2006055542A2 (en) * | 2004-11-15 | 2006-05-26 | Nitromed, Inc. | Diuretic compounds comprising heterocyclic nitric oxide donor groups, compositions and methods of use |
WO2006078995A1 (en) * | 2005-01-21 | 2006-07-27 | Nitromed, Inc. | Cardiovascular compounds comprising heterocyclic nitric oxide donor group compositions and methods of use |
WO2006083779A2 (en) * | 2005-01-31 | 2006-08-10 | Mylan Laboratories, Inc. | Pharmaceutical composition comprising hydroxylated nebivolol |
AU2006336387A1 (en) * | 2005-02-16 | 2007-08-02 | Nicox S.A. | Organic nitric oxide donor salts of antimicrobial compounds, compositions and methods of use |
AU2006218766A1 (en) * | 2005-02-28 | 2006-09-08 | Nicox S.A. | Cardiovascular compounds comprising nitric oxide enhancing groups, compositions and methods of use |
EP1861093A2 (en) * | 2005-03-09 | 2007-12-05 | Nitromed, Inc. | Organic nitric oxide enhancing salts of angiotensin ii antagonists, compositions and methods of use |
EP2808015A1 (en) | 2005-05-31 | 2014-12-03 | Mylan Laboratories, Inc | Compositions comprising nebivolol |
WO2007016677A2 (en) | 2005-08-02 | 2007-02-08 | Nitromed, Inc. | Nitric oxide enhancing antimicrobial compounds, compositions and methods of use |
CA2624933A1 (en) * | 2005-10-04 | 2007-04-12 | Nitromed, Inc. | Methods for treating respiratory disorders |
US8119358B2 (en) | 2005-10-11 | 2012-02-21 | Tethys Bioscience, Inc. | Diabetes-related biomarkers and methods of use thereof |
EP1954685A4 (en) * | 2005-11-16 | 2009-11-11 | Nitromed Inc | FUROXANE COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
US20090053328A1 (en) * | 2005-12-20 | 2009-02-26 | Nitromed, Inc. | Nitric Oxide Enhancing Glutamic Acid Compounds, Compositions and Methods of Use |
US20080293702A1 (en) * | 2005-12-22 | 2008-11-27 | Nitromed, Inc. | Nitric Oxide Enhancing Pyruvate Compounds, Compositions and Methods of Use |
US20080057590A1 (en) | 2006-06-07 | 2008-03-06 | Mickey Urdea | Markers associated with arteriovascular events and methods of use thereof |
US7897360B2 (en) * | 2006-12-15 | 2011-03-01 | Kimberly-Clark Worldwide, Inc. | Enzyme detection techniques |
DK2147315T3 (da) | 2007-04-18 | 2013-09-23 | Tethys Bioscience Inc | Diabetesrelaterede biomarkører og fremgangsmåder til anvendelse deraf |
US7828840B2 (en) * | 2007-11-15 | 2010-11-09 | Med Institute, Inc. | Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists |
GB2462022B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof |
SG182821A1 (en) | 2010-02-01 | 2012-08-30 | Hospital For Sick Children | Remote ischemic conditioning for treatment and prevention of restenosis |
AU2011234189B2 (en) | 2010-03-31 | 2015-12-03 | The Hospital For Sick Children | Use of remote ischemic conditioning to improve outcome after myocardial infarction |
CN107674071B (zh) | 2012-05-11 | 2021-12-31 | 同步制药公司 | 作为隐花色素调节剂的含有咔唑的磺酰胺类 |
PT2879666T (pt) | 2012-08-01 | 2020-05-07 | Tavakoli Zahra | Composições congeladas, de fluxo livre contendo um agente terapêutico |
US20160024098A1 (en) | 2013-03-15 | 2016-01-28 | President And Fellows Of Harvard College | Hybrid necroptosis inhibitors |
TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
WO2018074455A1 (ja) * | 2016-10-21 | 2018-04-26 | 富士レビオ株式会社 | レニン濃度の免疫学的測定法 |
CN107007849A (zh) * | 2017-06-19 | 2017-08-04 | 河北省人民医院 | 一种建立甲减性心功能不全大鼠动物模型的方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
-
1985
- 1985-03-28 US US06/717,738 patent/US4780401A/en not_active Expired - Fee Related
- 1985-04-03 DE DE8585810152T patent/DE3580056D1/de not_active Expired - Lifetime
- 1985-04-03 EP EP85810152A patent/EP0158599B1/de not_active Expired - Lifetime
- 1985-04-03 AT AT85810152T patent/ATE57392T1/de not_active IP Right Cessation
- 1985-04-03 NO NO851384A patent/NO165556C/no unknown
- 1985-04-03 FI FI851334A patent/FI87933C/fi not_active IP Right Cessation
- 1985-04-03 DK DK153385A patent/DK165326C/da not_active IP Right Cessation
- 1985-04-04 AU AU40886/85A patent/AU591870B2/en not_active Ceased
- 1985-04-04 ZA ZA852557A patent/ZA852557B/xx unknown
- 1985-04-04 IE IE876/85A patent/IE57956B1/en not_active IP Right Cessation
- 1985-04-04 CA CA000478371A patent/CA1277261C/en not_active Expired - Lifetime
- 1985-04-08 JP JP60072857A patent/JPH0669390B2/ja not_active Expired - Lifetime
- 1985-04-08 ES ES542017A patent/ES8707295A1/es not_active Expired
-
1986
- 1986-08-14 ES ES557016A patent/ES8802254A1/es not_active Expired
-
1988
- 1988-06-23 JP JP63153660A patent/JPH0669371B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FI851334A0 (fi) | 1985-04-03 |
AU4088685A (en) | 1985-10-17 |
DK153385D0 (da) | 1985-04-03 |
EP0158599A3 (en) | 1987-12-16 |
DK153385A (da) | 1985-10-10 |
DE3580056D1 (de) | 1990-11-15 |
EP0158599A2 (de) | 1985-10-16 |
CA1277261C (en) | 1990-12-04 |
ES8802254A1 (es) | 1988-04-16 |
ES8707295A1 (es) | 1987-07-16 |
IE850876L (en) | 1985-10-09 |
FI851334L (fi) | 1985-10-10 |
FI87933C (fi) | 1993-03-10 |
NO851384L (no) | 1985-10-10 |
JPS60231624A (ja) | 1985-11-18 |
DK165326C (da) | 1993-03-29 |
DK165326B (da) | 1992-11-09 |
ATE57392T1 (de) | 1990-10-15 |
AU591870B2 (en) | 1989-12-21 |
ES542017A0 (es) | 1987-07-16 |
JPS6485070A (en) | 1989-03-30 |
JPH0669371B2 (ja) | 1994-09-07 |
NO165556C (no) | 1991-02-27 |
US4780401A (en) | 1988-10-25 |
FI87933B (fi) | 1992-11-30 |
ZA852557B (en) | 1985-11-27 |
NO165556B (no) | 1990-11-19 |
EP0158599B1 (de) | 1990-10-10 |
IE57956B1 (en) | 1993-05-19 |
JPH0669390B2 (ja) | 1994-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted | ||
FD1A | Patent lapsed |
Effective date: 20001102 |