ZA841455B - Sulfonate containing ester prodrugs of corticosteroids - Google Patents

Sulfonate containing ester prodrugs of corticosteroids

Info

Publication number
ZA841455B
ZA841455B ZA841455A ZA841455A ZA841455B ZA 841455 B ZA841455 B ZA 841455B ZA 841455 A ZA841455 A ZA 841455A ZA 841455 A ZA841455 A ZA 841455A ZA 841455 B ZA841455 B ZA 841455B
Authority
ZA
South Africa
Prior art keywords
corticosteroids
containing ester
ester prodrugs
sulfonate containing
sulfonate
Prior art date
Application number
ZA841455A
Other languages
English (en)
Inventor
Bradley Dale Anderson
Robert Allen Conradi
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA841455B publication Critical patent/ZA841455B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ZA841455A 1983-03-30 1984-02-27 Sulfonate containing ester prodrugs of corticosteroids ZA841455B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/480,603 US4469689A (en) 1983-03-30 1983-03-30 Sulfonate containing ester prodrugs of corticosteroids

Publications (1)

Publication Number Publication Date
ZA841455B true ZA841455B (en) 1984-10-31

Family

ID=23908597

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA841455A ZA841455B (en) 1983-03-30 1984-02-27 Sulfonate containing ester prodrugs of corticosteroids

Country Status (6)

Country Link
US (1) US4469689A (cs)
EP (1) EP0124233B1 (cs)
JP (1) JPS59191000A (cs)
CA (1) CA1202616A (cs)
DE (1) DE3479891D1 (cs)
ZA (1) ZA841455B (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
EP0221705A1 (en) * 1985-10-23 1987-05-13 The Upjohn Company Tetrahydro angiostatic steroids
US5250711A (en) * 1987-07-16 1993-10-05 The Upjohn Company Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl) amides
KR890701552A (ko) * 1987-07-16 1989-12-20 로버트 에이.아미테이지 알칸-1, n-디카복실 산 모노-(2-설페이토에틸)아마이드의 아민 염
CA2152374A1 (en) * 1993-01-08 1994-07-21 Ralph Lennart Brattsand Novel colon- or ileum-specific steroid derivatives
IT1293510B1 (it) * 1997-07-30 1999-03-01 Gentili Ist Spa Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi
ATE342716T1 (de) * 1999-12-21 2006-11-15 Univ Gent Verwendung von carboxy verbindungen wie 2(4- acetoxyphenyl)-2-chloro-n-methyl-ethylammonium chlorid als entzündungshemmende mittel
KR100472303B1 (ko) * 2002-05-21 2005-03-08 김영미 결장표적성 프로드럭으로서의 코티코스테로이드21-설페이트 소듐 유도체
EP1562627A4 (en) * 2002-08-23 2006-11-02 Mclean Hospital Corp CORTICOSTEROID CONJUGATES AND ITS USES
BRPI0908229A8 (pt) 2008-02-25 2017-10-10 Eyegate Pharma S A S Uso de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste, kit e dispositivo para dispensar iontoforeticamente um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente para tratar um distúrbio ocular mediado por inflamação no referido paciente, e, formulação apropriada para dispensação iontoforética ocular de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente
US20100048524A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
JP2012516900A (ja) * 2009-02-05 2012-07-26 トーカイ ファーマシューティカルズ，インク． ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ
EP2780009A4 (en) * 2011-11-17 2015-05-06 Univ Colorado Regents METHOD AND COMPOSITIONS FOR IMPROVED DRUG RELEASE INTO EYE AND FORMULATIONS WITH EXTENDED RELEASE
WO2013177198A1 (en) 2012-05-21 2013-11-28 The Regents Of The University Of Colorado, A Body Corporate Ledgf peptides and formulations thereof for treatment of degenerative disorders
JP2016514165A (ja) 2013-03-14 2016-05-19 ユニバーシティー オブ メリーランド，ボルティモア アンドロゲン受容体下方制御剤及びその使用
US9808472B2 (en) 2013-08-12 2017-11-07 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
US11661398B2 (en) 2017-10-02 2023-05-30 Scientist of Fortune, S.A. Cellular transport system for transferring a sulfonic acid construct carrying a cargo into the cytoplasm of a cell

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
US2986559A (en) * 1959-01-07 1961-05-30 Schering Corp Novel therapeutic salts and processes for their manufacture
FR2408622A1 (fr) * 1977-05-06 1979-06-08 Roussel Uclaf Nouveaux derives du pregn 4-ene, leur procede de preparation et leur application comme medicament
DK404879A (da) * 1978-10-04 1980-04-05 Schering Ag Kortikoid-21-sulfopropionater og deres salte fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende disse forbindelser

Also Published As

Publication number Publication date
CA1202616A (en) 1986-04-01
EP0124233A2 (en) 1984-11-07
EP0124233A3 (en) 1985-01-16
DE3479891D1 (en) 1989-11-02
EP0124233B1 (en) 1989-09-27
JPS59191000A (ja) 1984-10-29
US4469689A (en) 1984-09-04
JPH041760B2 (cs) 1992-01-14

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