ZA821790B - Novel thiazole derivatives,process for their manufacture,pharmaceutical compositions containing same and their use - Google Patents

Novel thiazole derivatives,process for their manufacture,pharmaceutical compositions containing same and their use

Info

Publication number
ZA821790B
ZA821790B ZA821790A ZA821790A ZA821790B ZA 821790 B ZA821790 B ZA 821790B ZA 821790 A ZA821790 A ZA 821790A ZA 821790 A ZA821790 A ZA 821790A ZA 821790 B ZA821790 B ZA 821790B
Authority
ZA
South Africa
Prior art keywords
manufacture
pharmaceutical compositions
compositions containing
containing same
thiazole derivatives
Prior art date
Application number
ZA821790A
Other languages
English (en)
Inventor
Pier Giorgio Ferrini
Richard Goeschke
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of ZA821790B publication Critical patent/ZA821790B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA821790A 1981-03-18 1982-03-17 Novel thiazole derivatives,process for their manufacture,pharmaceutical compositions containing same and their use ZA821790B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH183881 1981-03-18

Publications (1)

Publication Number Publication Date
ZA821790B true ZA821790B (en) 1983-01-26

Family

ID=4219779

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA821790A ZA821790B (en) 1981-03-18 1982-03-17 Novel thiazole derivatives,process for their manufacture,pharmaceutical compositions containing same and their use

Country Status (16)

Country Link
US (1) US4451471A (fi)
EP (1) EP0061425A3 (fi)
JP (1) JPS57183767A (fi)
KR (1) KR830009066A (fi)
AU (1) AU8166782A (fi)
DK (1) DK118482A (fi)
ES (8) ES8400102A1 (fi)
FI (1) FI820877L (fi)
GB (1) GB2098203B (fi)
GR (1) GR78347B (fi)
HU (1) HU187684B (fi)
IL (1) IL65285A (fi)
NO (1) NO820881L (fi)
NZ (1) NZ200038A (fi)
PT (1) PT74593B (fi)
ZA (1) ZA821790B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4632930A (en) * 1984-11-30 1986-12-30 E. I. Du Pont De Nemours And Company Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives
DE3508666A1 (de) * 1985-03-12 1986-09-18 Hoechst Ag, 6230 Frankfurt Heterocyclische disulfide und ihre anwendung als immunmodulatoren
DE3508665A1 (de) * 1985-03-12 1986-09-18 Hoechst Ag, 6230 Frankfurt Heterocyclische sulfide und ihre anwendung als immunmodulatoren
JPS6339868A (ja) * 1986-08-04 1988-02-20 Otsuka Pharmaceut Factory Inc ジ低級アルキルフエノ−ル誘導体
EP0301613B1 (en) * 1987-07-27 1991-07-10 Duphar International Research B.V Thiazole compounds having fungicidal activity
AT392788B (de) * 1988-02-03 1991-06-10 Fisons Plc Neue benzimidazolverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
DE3807232A1 (de) * 1988-03-05 1989-09-14 Bayer Ag Substituierte acrylsaeureester
JP2933739B2 (ja) * 1990-04-09 1999-08-16 明治製菓株式会社 チアゾールまたはイミダゾール誘導体および抗潰瘍剤
US5255697A (en) * 1991-10-23 1993-10-26 Working Inc. Walking support apparatus
JP2636819B2 (ja) 1994-12-20 1997-07-30 日本たばこ産業株式会社 オキサゾール系複素環式芳香族化合物
WO2001010865A1 (fr) * 1999-08-06 2001-02-15 Takeda Chemical Industries, Ltd. INHIBITEURS DE p38MAP KINASE
CA2636077C (en) * 2006-01-18 2012-01-03 Amgen Inc. Thiazole compounds as protein kinase b (pkb) inhibitors
CA2693473A1 (en) * 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of pkb
BR112015000507A2 (pt) 2012-07-12 2017-06-27 Chiesi Farm Spa inibição de enzimas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2129012A1 (de) * 1971-06-11 1973-01-04 Merck Patent Gmbh Azol-derivate
FR2146161A1 (en) * 1971-07-22 1973-03-02 Roussel Uclaf Thiazolyl thiolacetic acids - analgesics antiinflammatories and antipyretics
US3888870A (en) * 1974-03-08 1975-06-10 Sandoz Ag 2-sulfinyl-thiazoles and oxazoles
US4022607A (en) * 1975-06-09 1977-05-10 Sandoz, Inc. Substituted oxazoles and thiazoles as herbicides

Also Published As

Publication number Publication date
PT74593A (de) 1982-04-01
ES537342A0 (es) 1986-01-16
GR78347B (fi) 1984-09-26
ES8604180A1 (es) 1986-01-16
ES8603498A1 (es) 1985-12-16
NO820881L (no) 1982-09-20
ES8601171A1 (es) 1985-10-16
US4451471A (en) 1984-05-29
ES522868A0 (es) 1985-02-01
AU8166782A (en) 1982-09-23
ES8603499A1 (es) 1985-12-16
ES522867A0 (es) 1985-12-16
HU187684B (en) 1986-02-28
ES8603847A1 (es) 1986-01-01
EP0061425A2 (de) 1982-09-29
ES537343A0 (es) 1985-10-16
IL65285A (en) 1985-11-29
NZ200038A (en) 1985-05-31
EP0061425A3 (de) 1982-12-15
DK118482A (da) 1982-09-19
ES537277A0 (es) 1986-01-01
ES8502980A1 (es) 1985-02-01
KR830009066A (ko) 1983-12-17
GB2098203A (en) 1982-11-17
ES522869A0 (es) 1985-03-16
ES8503677A1 (es) 1985-03-16
FI820877L (fi) 1982-09-19
JPS57183767A (en) 1982-11-12
ES510504A0 (es) 1983-10-16
ES537278A0 (es) 1985-12-16
ES8400102A1 (es) 1983-10-16
PT74593B (de) 1984-11-27
IL65285A0 (en) 1982-05-31
GB2098203B (en) 1985-05-09

Similar Documents

Publication Publication Date Title
DE3263633D1 (en) Imidazodiazepines, process for their preparation and pharmaceutical compositions containing them
IL62082A0 (en) -lactam derivatives,process for the preparation thereof and pharmaceutical compositions containing them
IL66501A0 (en) Benzazepine-2-one derivatives,their manufacture and pharmaceutical compositions containing them
IL64345A (en) Substituted phenoxypropanolamine derivatives,process for the production thereof and pharmaceutical compositions containing the same
GB2140412B (en) Thiazolidine derivatives, process for the preparation and pharmaceutical compositions thereof
DE3273783D1 (en) Novel piperidine derivatives, processes for preparation thereof and pharmaceutical compositions containing same
PT75815B (en) Process for preparing morphinane derivatives and pharmaceutical compositions containing the same
PT75366B (en) Process for preparing thiazolidinylalkylene piperazine derivatives and pharmaceutical compositions containing the same
DE3161611D1 (en) Novel pyridinecarboxamide derivatives, a process for the preparation thereof, the use of said derivatives and a pharmaceutical composition containing same
DE3275296D1 (en) Azabicyclo-(3,3,1)-nonylbenzamide derivatives, processes for their preparation, and pharmaceutical compositions containing them
ZA821790B (en) Novel thiazole derivatives,process for their manufacture,pharmaceutical compositions containing same and their use
IL72139A0 (en) Thiazolidine derivatives,their manufacture and pharmaceutical compositions containing them
DE3167664D1 (en) Pyrazoloindazole derivatives, process for preparing the same, and pharmaceutical composition containing the same
DE3277838D1 (en) Thiazolylurea derivatives, process for their preparation, and medicinal composition containing same
DE3271383D1 (en) Ascochlorin derivatives; process for preparing the same and pharmaceutical composition containing the same
DE2961394D1 (en) 1-oxo-1h-pyrimido (6,1-b) benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing them
IL60468A (en) 4-sulfamoylphenyl-2-phenyl-imino-1,3-thiazole derivatives,process for their preparation and pharmaceutical compositions containing them
DE3273781D1 (en) Novel thiazole compounds, process for their preparation, and medicinal composition containing same
ZA848303B (en) 1,2-dithiolan derivatives,process for their production,pharmaceutical compositions containing them and their use
PT75365B (en) Process for preparing spirothiazolidinyl piperazine derivatives and pharmaceutical compositions containing the same
IL62747A (en) 2-guanidinothiazole derivatives,process for the preparation thereof and pharmaceutical compositions comprising the same
DE3061160D1 (en) 15-methanesulfonamidoprostaglandin derivatives, pharmaceutical compositions thereof and process therefor
IL62400A0 (en) Thiazole derivatives,their preparation and pharmaceutical compositions containing them
ZA826528B (en) Ascochlorin derivatives,process for preparing the same and pharmaceutical composition containing the same
ZA813068B (en) Benzothiazole compound,process for its preparation,and pharmaceutical compositions