ZA821449B - Novel fluoro prostacyclins - Google Patents

Novel fluoro prostacyclins

Info

Publication number
ZA821449B
ZA821449B ZA821449A ZA821449A ZA821449B ZA 821449 B ZA821449 B ZA 821449B ZA 821449 A ZA821449 A ZA 821449A ZA 821449 A ZA821449 A ZA 821449A ZA 821449 B ZA821449 B ZA 821449B
Authority
ZA
South Africa
Prior art keywords
prostacyclins
novel fluoro
fluoro
novel
fluoro prostacyclins
Prior art date
Application number
ZA821449A
Other languages
English (en)
Inventor
George William Holland
Hans Maag
Perry Rosen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA821449B publication Critical patent/ZA821449B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA821449A 1981-03-11 1982-03-04 Novel fluoro prostacyclins ZA821449B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24281881A 1981-03-11 1981-03-11

Publications (1)

Publication Number Publication Date
ZA821449B true ZA821449B (en) 1983-01-26

Family

ID=22916307

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA821449A ZA821449B (en) 1981-03-11 1982-03-04 Novel fluoro prostacyclins

Country Status (5)

Country Link
JP (1) JPS57171988A (fr)
KR (1) KR860002049B1 (fr)
BE (1) BE892434A (fr)
GR (1) GR76075B (fr)
ZA (1) ZA821449B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57200378A (en) * 1981-06-02 1982-12-08 Teijin Ltd Halogenated pgi2 and its preparation
US4472428A (en) * 1980-12-09 1984-09-18 Teijin Limited Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore
JPS57165382A (en) * 1981-04-06 1982-10-12 Teijin Ltd Fluoro-pgi2 compound and its preparation
JPS58150583A (ja) * 1982-03-04 1983-09-07 Teijin Ltd 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物
JPS59227888A (ja) * 1983-06-10 1984-12-21 Asahi Glass Co Ltd ７−フルオロプロスタグランジン類の製造方法
DE69502517T2 (de) * 1994-02-17 1998-10-01 Asahi Glass Co Ltd Difluorprostacycline, Zwischenprodukte und Verfahren zu deren Herstellung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU184917B (en) * 1980-10-27 1984-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 7-substituted pgi down 2 derivatives
JPS57165382A (en) * 1981-04-06 1982-10-12 Teijin Ltd Fluoro-pgi2 compound and its preparation

Also Published As

Publication number Publication date
KR860002049B1 (ko) 1986-11-20
GR76075B (fr) 1984-08-03
JPS57171988A (en) 1982-10-22
BE892434A (fr) 1982-09-10
KR830009079A (ko) 1983-12-17

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