ZA80996B - Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations - Google Patents

Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations

Info

Publication number
ZA80996B
ZA80996B ZA00800996A ZA80996A ZA80996B ZA 80996 B ZA80996 B ZA 80996B ZA 00800996 A ZA00800996 A ZA 00800996A ZA 80996 A ZA80996 A ZA 80996A ZA 80996 B ZA80996 B ZA 80996B
Authority
ZA
South Africa
Prior art keywords
synthesis
salts
pharmaceutical formulations
imidazole derivatives
imidazole
Prior art date
Application number
ZA00800996A
Other languages
English (en)
Inventor
P Thorogood
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ZA80996B publication Critical patent/ZA80996B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/14Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/36Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA00800996A 1979-02-22 1980-02-21 Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations ZA80996B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7906243 1979-02-22

Publications (1)

Publication Number Publication Date
ZA80996B true ZA80996B (en) 1981-04-29

Family

ID=10503360

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00800996A ZA80996B (en) 1979-02-22 1980-02-21 Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations

Country Status (20)

Country Link
US (2) US4328234A (ko)
EP (1) EP0015002B1 (ko)
JP (1) JPS55115872A (ko)
KR (1) KR850000380B1 (ko)
AT (1) AT373881B (ko)
AU (1) AU531899B2 (ko)
DE (1) DE3067505D1 (ko)
DK (1) DK75680A (ko)
ES (1) ES8103055A1 (ko)
FI (1) FI800519A (ko)
GB (1) GB2044259B (ko)
GR (1) GR70277B (ko)
HU (1) HU188123B (ko)
IE (1) IE49744B1 (ko)
IL (1) IL59444A0 (ko)
IT (1) IT1128095B (ko)
MC (1) MC1315A1 (ko)
NZ (1) NZ192941A (ko)
PT (1) PT70856B (ko)
ZA (1) ZA80996B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT70856B (en) * 1979-02-22 1981-06-11 Wellcome Found Imidazole derivatives and salts thereof their synthesis and pharmaceutical formulations
DE2944663A1 (de) * 1979-11-06 1981-05-14 Bayer Ag, 5090 Leverkusen Imidazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE2944662A1 (de) * 1979-11-06 1981-05-14 Bayer Ag, 5090 Leverkusen Cycloheptatrienylimidazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
JPS6036427B2 (ja) * 1980-12-05 1985-08-20 塩野義製薬株式会社 1−ベンジルイミダゾ−ル誘導体
ATE29494T1 (de) * 1983-08-11 1987-09-15 Synthelabo Indol-derivate, verfahren zu deren herstellung und deren therapeutische anwendung.
DE3508905A1 (de) * 1985-03-13 1986-09-18 Hoechst Ag, 6230 Frankfurt Neue imidazolylverbindungen und verfahren zu ihrer herstellung
US4783474A (en) * 1985-07-20 1988-11-08 Bayer Aktiengesellschaft Halogenoalkyl-, alkenyl- and alkinyl-azoles
DE3700916A1 (de) * 1987-01-14 1988-07-28 Bayer Ag Halogenalkyl-, alkenyl- und alkinyl-azole
US5272167A (en) * 1986-12-10 1993-12-21 Schering Corporation Pharmaceutically active compounds
DE3827117A1 (de) * 1988-08-10 1990-02-15 Ruetgerswerke Ag Verfahren zur herstellung von chinuclidin-3-methanol
IT1251431B (it) * 1991-10-25 1995-05-09 Costante Fontana Composto ad elevate caratteristiche stabilizzanti particolarmente per perossidi inorganici utilizzati in applicazioni industriali
DE69637097T2 (de) * 1995-10-13 2007-09-20 Neurosearch A/S 8-Azabicyclo(3.2.1)Oct-2-en-Derivate, deren Herstellung und Anwendung
MX2007012091A (es) * 2005-03-31 2007-11-20 Schering Corp Antagonistas espirociclicos de los receptores de trombina.

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US29935A (en) * 1860-09-04 Joseph f
US2836598A (en) * 1958-05-27 Tertiary-amino - substituted i
US3259637A (en) * 1963-05-27 1966-07-05 Frosst & Co Charles E 3, 3-dimethyl-8-bromomethyl-2, 7-dioxaspiro (4.4)nonane
GB1164564A (en) 1967-08-21 1969-09-17 Shell Int Research Novel Cyclobexylpentadienone Acid Derivatives, the preparation thereof and Compositions containing the same
USRE29935E (en) * 1968-11-29 1979-03-13 Bayer Aktiengesellschaft N-Substituted imidazoles and their salts
DE2007794A1 (de) * 1970-02-20 1971-09-02 Farbenfabriken Bayer Aktiengesell schaft, 5090 Leverkusen Fungizide Mittel
US3666755A (en) * 1970-03-26 1972-05-30 Merck & Co Inc 2-imidazolylbicyclo{8 2.2.2{9 octanes
DE2016839C3 (de) * 1970-04-09 1979-03-22 Bayer Ag, 5090 Leverkusen PhenyM4-phenoxyphenyi)-imidazol-1-yl-methane, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
US3682951A (en) * 1970-11-02 1972-08-08 Searle & Co 1-{8 {62 -(1-adamantyloxy)halophenethyl{9 {0 imidazoles and congeners
FR2129838A1 (en) * 1971-03-16 1972-11-03 Boehringer Mannheim Gmbh Diuretic/saluretic dibenzo cycloheptene - derivs
US4107206A (en) * 1974-04-08 1978-08-15 Akzona Incorporated Benzo-bicyclononene- derivatives
SE7600674L (sv) * 1975-02-05 1976-08-06 Rohm & Haas Fungicider
US4057549A (en) * 1975-04-16 1977-11-08 G. D. Searle & Co. Triarylpropyl-azabicyclooctanes
US4156694A (en) * 1975-04-29 1979-05-29 Akzona Incorporated Benzobicyclononene derivatives
US4036975A (en) * 1975-07-28 1977-07-19 Xyntex (U.S.A) Inc. 1-[2-(1-Adamantyl)-2-(R-thio)ethyl]imidazoles and 1-[2-(1-adamantyl)-2-(R-oxy)ethyl]imidazoles
US4031224A (en) * 1976-04-29 1977-06-21 American Hoechst Corporation 1,3-Dihydro-heteroarylspiro (isobenzofuran)s
US4396771A (en) * 1977-10-19 1983-08-02 Burroughs Wellcome Co. Imidazole derivatives and salts thereof
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
PT70856B (en) * 1979-02-22 1981-06-11 Wellcome Found Imidazole derivatives and salts thereof their synthesis and pharmaceutical formulations

Also Published As

Publication number Publication date
AT373881B (de) 1984-02-27
DK75680A (da) 1980-08-23
KR850000380B1 (ko) 1985-03-23
EP0015002A1 (en) 1980-09-03
AU531899B2 (en) 1983-09-08
ATA97580A (de) 1983-07-15
EP0015002B1 (en) 1984-04-18
GB2044259B (en) 1983-08-03
IE49744B1 (en) 1985-12-11
IL59444A0 (en) 1980-05-30
IE800341L (en) 1980-08-22
KR830001904A (ko) 1983-05-19
JPS55115872A (en) 1980-09-06
IT8047968A0 (it) 1980-02-21
DE3067505D1 (en) 1984-05-24
ES488803A0 (es) 1981-02-16
US4328234A (en) 1982-05-04
AU5576580A (en) 1980-08-28
IT1128095B (it) 1986-05-28
GR70277B (ko) 1982-09-03
NZ192941A (en) 1984-10-19
PT70856B (en) 1981-06-11
US4525475A (en) 1985-06-25
HU188123B (en) 1986-03-28
FI800519A (fi) 1980-08-23
ES8103055A1 (es) 1981-02-16
GB2044259A (en) 1980-10-15
MC1315A1 (fr) 1981-03-10
PT70856A (en) 1980-03-01

Similar Documents

Publication Publication Date Title
DE2966948D1 (en) Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations
DE2861237D1 (en) Imidazole derivatives their synthesis and their pharmaceutical formulations
DE2965062D1 (en) Imidazole derivatives, their preparation and pharmaceutical compositions
DE2862445D1 (en) Hydantoin derivatives and salts thereof, their synthesis and pharmaceutical formulations
ZA80996B (en) Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations
IL60470A0 (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
IL57040A (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
DE2862404D1 (en) Hydantoin derivatives, their preparation and pharmaceutical compositions containing them
IL59410A0 (en) Pyrazole derivatives,pharmaceutical formulations containing these derivatives and processes for their preparation
DE2966204D1 (en) Eburnane derivatives, their synthesis and pharmaceutical compositions containing them
DE2861638D1 (en) Hydantoin derivatives and salts thereof, their synthesis and intermediates, and pharmaceutical formulations
IL55858A (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
PH15625A (en) Pyridazopyridazine derivatives,their pharmaceutical compositions and their use
IL54819A (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
IL53995A (en) Imidazole derivatives,their preparation and pharmaceutical compositions containing them
GB2010813B (en) Imidazole derivatives and salts thereof their synthesis and intermediates and pharmaceutical formulations
DE2860796D1 (en) Tantomeric arylaminoimidazoline derivatives, their preparation and pharmaceutical formulations for analgetic application containing them
DE3378118D1 (en) Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations
DE3061830D1 (en) Hydantoin derivatives, their preparation and pharmaceutical compositions
GB2008089B (en) Imidazole derivatives and salts thereof their synthesis and intermediates and pharmaceutical formulations
ZA835967B (en) Imidazole derivatives and salts thereof,their synthesis,and pharmaceutical formulations
DE2963796D1 (en) Imidazole derivatives, pharmaceutical compositions containing them and their preparation
GB2006752B (en) Imidazole derivatives and salts thereof their synthesis and intermediates and pharmaceutical formulations
DE2862424D1 (en) Hydantoin derivatives, their synthesis, pharmaceutical formulations and intermediates in their preparation
IL52229A (en) Hydantoin derivatives,their preparation and pharmaceutical compositions containing them