ZA802909B - Pyrimidine compounds, processes for their preparation, pharmaceutical preparations containing these compounds, and their use in therapeutics - Google Patents
Pyrimidine compounds, processes for their preparation, pharmaceutical preparations containing these compounds, and their use in therapeuticsInfo
- Publication number
- ZA802909B ZA802909B ZA00802909A ZA802909A ZA802909B ZA 802909 B ZA802909 B ZA 802909B ZA 00802909 A ZA00802909 A ZA 00802909A ZA 802909 A ZA802909 A ZA 802909A ZA 802909 B ZA802909 B ZA 802909B
- Authority
- ZA
- South Africa
- Prior art keywords
- compounds
- therapeutics
- processes
- preparation
- pharmaceutical preparations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH466979 | 1979-05-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA802909B true ZA802909B (en) | 1981-05-27 |
Family
ID=4280399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA00802909A ZA802909B (en) | 1979-05-18 | 1980-05-16 | Pyrimidine compounds, processes for their preparation, pharmaceutical preparations containing these compounds, and their use in therapeutics |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0019811A1 (fr) |
JP (1) | JPS55154971A (fr) |
KR (1) | KR830002757A (fr) |
AR (1) | AR228256A1 (fr) |
AU (1) | AU5848480A (fr) |
DD (1) | DD150609A5 (fr) |
DK (1) | DK214480A (fr) |
ES (1) | ES491514A0 (fr) |
FI (1) | FI801600A (fr) |
GB (1) | GB2052487B (fr) |
GR (1) | GR68453B (fr) |
IE (1) | IE49803B1 (fr) |
IL (1) | IL60086A (fr) |
MA (1) | MA18829A1 (fr) |
NO (1) | NO801469L (fr) |
NZ (1) | NZ193730A (fr) |
OA (1) | OA06533A (fr) |
PL (1) | PL224313A1 (fr) |
PT (1) | PT71251A (fr) |
ZA (1) | ZA802909B (fr) |
ZW (1) | ZW11880A1 (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507146A (en) * | 1982-12-28 | 1985-03-26 | Ciba-Geigy Corporation | 2,4-Diamino-6-halo-5-trifluoromethylpyrimidines having herbicidal activity |
DE3829469A1 (de) * | 1988-08-31 | 1990-03-01 | Bayer Ag | Verfahren zur herstellung von substituierten n-azinyl-n'-sulfonyl-isothioharnstoffen und n-azinyl-iminodithiokohlensaeure-s,s-diester als zwischenprodukte zu ihrer herstellung |
WO1999011269A1 (fr) * | 1997-09-03 | 1999-03-11 | Eli Lilly And Company | Derives de pyrimidine |
US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
EP1318997B1 (fr) | 2000-09-15 | 2006-05-31 | Vertex Pharmaceuticals Incorporated | Composes pyrazole utiles en tant qu'inhibiteurs de proteine kinase |
IL156368A0 (en) | 2000-12-21 | 2004-01-04 | Vertex Pharma | Pyrazole derivatives and pharmaceutical compositions containing the same |
BR0206844A (pt) * | 2001-01-31 | 2005-07-12 | Synaptic Pharma Corp | Uso de antagonistas do receptor gal3 para o tratamento de depressão e/ou ansiedade e compostos usados em tais métodos |
CA2479036A1 (fr) | 2002-03-13 | 2003-09-18 | Euro-Celtique S.A. | Pyrimidines substituees par aryle et utilisation associee |
WO2003078427A1 (fr) | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Azolylaminoazines inhibitrices des proteines kinases |
AU2003214110A1 (en) * | 2002-03-15 | 2003-09-29 | Ciba Specialty Chemicals Holding Inc. | 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces |
MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
WO2004013140A1 (fr) | 2002-08-02 | 2004-02-12 | Vertex Pharmaceuticals Incorporated | Compositions pyrazole convenant comme inhibiteurs de gsk-3 |
US7601718B2 (en) | 2003-02-06 | 2009-10-13 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
WO2007022384A2 (fr) | 2005-08-18 | 2007-02-22 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de pyrazine kinases |
SG166828A1 (en) | 2005-11-03 | 2010-12-29 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
AU2007317435A1 (en) | 2006-11-02 | 2008-05-15 | Vertex Pharmaceuticals Incorporated | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases |
DE602007007985D1 (de) | 2006-12-19 | 2010-09-02 | Vertex Pharma | Als inhibitoren von proteinkinasen geeignete aminopyrimidine |
ES2435997T3 (es) | 2007-03-09 | 2013-12-26 | Vertex Pharmaceuticals, Inc. | Aminopirimidinas útiles como inhibidores de las proteínas cinasas |
RU2009137390A (ru) | 2007-03-09 | 2011-04-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Аминопиримидины, пригодные в качестве ингибиторов протеинкиназ |
JP2010520887A (ja) | 2007-03-09 | 2010-06-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | 蛋白キナーゼの阻害剤として有用なアミノピリジン |
AU2008240313A1 (en) | 2007-04-13 | 2008-10-23 | Aj Park | Aminopyrimidines useful as kinase inhibitors |
MX2009011812A (es) | 2007-05-02 | 2010-01-14 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasa. |
EP2152694A2 (fr) | 2007-05-02 | 2010-02-17 | Vertex Pharmaceuticals Incorporated | Thiazoles et pyrazoles qui s'utilisent comme inhibiteurs de kinase |
EP2176261B1 (fr) | 2007-07-31 | 2012-12-19 | Vertex Pharmaceuticals Incorporated | Procédé de préparation de la 5-fluoro-1h-pyrazolo [3,4-b] pyridin-3-amine et des dérivés de celle-ci |
WO2010027921A1 (fr) | 2008-09-03 | 2010-03-11 | Vertex Pharmaceuticals Incorporated | Co-cristaux et formulations pharmaceutiques les comprenant |
ES2467108T3 (es) * | 2008-12-09 | 2014-06-11 | Gilead Sciences, Inc. | Moduladores de receptores tipo toll |
KR102328682B1 (ko) * | 2018-08-27 | 2021-11-18 | 주식회사 대웅제약 | 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE754832A (fr) * | 1969-08-14 | 1971-02-15 | Beecham Group Ltd | Iminazolines |
-
1980
- 1980-05-05 MA MA19025A patent/MA18829A1/fr unknown
- 1980-05-13 DD DD80221082A patent/DD150609A5/de unknown
- 1980-05-14 ES ES491514A patent/ES491514A0/es active Granted
- 1980-05-15 NZ NZ193730A patent/NZ193730A/xx unknown
- 1980-05-15 IL IL60086A patent/IL60086A/xx unknown
- 1980-05-16 PT PT71251A patent/PT71251A/pt unknown
- 1980-05-16 EP EP80102724A patent/EP0019811A1/fr not_active Withdrawn
- 1980-05-16 NO NO801469A patent/NO801469L/no unknown
- 1980-05-16 FI FI801600A patent/FI801600A/fi not_active Application Discontinuation
- 1980-05-16 ZA ZA00802909A patent/ZA802909B/xx unknown
- 1980-05-16 DK DK214480A patent/DK214480A/da not_active Application Discontinuation
- 1980-05-16 GB GB8016309A patent/GB2052487B/en not_active Expired
- 1980-05-16 AU AU58484/80A patent/AU5848480A/en not_active Abandoned
- 1980-05-16 ZW ZW118/80A patent/ZW11880A1/xx unknown
- 1980-05-16 GR GR61963A patent/GR68453B/el unknown
- 1980-05-16 IE IE1023/80A patent/IE49803B1/en unknown
- 1980-05-17 OA OA57113A patent/OA06533A/fr unknown
- 1980-05-17 JP JP6586380A patent/JPS55154971A/ja active Pending
- 1980-05-17 KR KR1019800001944A patent/KR830002757A/ko unknown
- 1980-05-17 PL PL22431380A patent/PL224313A1/xx unknown
- 1980-05-19 AR AR281109A patent/AR228256A1/es active
Also Published As
Publication number | Publication date |
---|---|
DD150609A5 (de) | 1981-09-09 |
EP0019811A1 (fr) | 1980-12-10 |
FI801600A (fi) | 1980-11-19 |
IE49803B1 (en) | 1985-12-25 |
IL60086A (en) | 1984-03-30 |
GB2052487B (en) | 1983-05-11 |
GR68453B (fr) | 1981-12-30 |
AU5848480A (en) | 1980-11-20 |
PT71251A (en) | 1980-06-01 |
IL60086A0 (en) | 1980-07-31 |
IE801023L (en) | 1980-11-18 |
PL224313A1 (fr) | 1981-02-13 |
MA18829A1 (fr) | 1980-12-31 |
JPS55154971A (en) | 1980-12-02 |
ES8104279A1 (es) | 1981-04-16 |
GB2052487A (en) | 1981-01-28 |
DK214480A (da) | 1980-11-19 |
OA06533A (fr) | 1981-07-31 |
NZ193730A (en) | 1982-12-21 |
ZW11880A1 (en) | 1980-12-17 |
KR830002757A (ko) | 1983-05-30 |
AR228256A1 (es) | 1983-02-15 |
NO801469L (no) | 1980-11-19 |
ES491514A0 (es) | 1981-04-16 |
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