IE801023L - Pyrimidinylamino diazacycloalkenes - Google Patents
Pyrimidinylamino diazacycloalkenesInfo
- Publication number
- IE801023L IE801023L IE801023A IE102380A IE801023L IE 801023 L IE801023 L IE 801023L IE 801023 A IE801023 A IE 801023A IE 102380 A IE102380 A IE 102380A IE 801023 L IE801023 L IE 801023L
- Authority
- IE
- Ireland
- Prior art keywords
- diazacycloalkenes
- pyrimidinylamino
- compounds
- nitrogen
- separates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of the formula I <IMAGE> in which Py represents an optionally substituted 4-or 5-pyrimidinyl radical bonded via a carbon atom to the nitrogen atom, R1 and R2 independently of one another represent hydrogen, lower alkyl or lower alkenyl, and Alk represents lower alkylene which separates the two nitrogen atoms by 2 to 4 carbon atoms, their tautomeric compounds and salts, exhibit hypotensive and antihypertensive effects.
[EP0019811A1]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH466979 | 1979-05-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE801023L true IE801023L (en) | 1980-11-18 |
IE49803B1 IE49803B1 (en) | 1985-12-25 |
Family
ID=4280399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE1023/80A IE49803B1 (en) | 1979-05-18 | 1980-05-16 | 4-or 5-pyrimidinyl-amino-1,3-diaza-2-cycloalkenes,processes for their preparation,pharmaceutical preparations containing these compounds,and their use in therapeutics |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0019811A1 (en) |
JP (1) | JPS55154971A (en) |
KR (1) | KR830002757A (en) |
AR (1) | AR228256A1 (en) |
AU (1) | AU5848480A (en) |
DD (1) | DD150609A5 (en) |
DK (1) | DK214480A (en) |
ES (1) | ES491514A0 (en) |
FI (1) | FI801600A (en) |
GB (1) | GB2052487B (en) |
GR (1) | GR68453B (en) |
IE (1) | IE49803B1 (en) |
IL (1) | IL60086A (en) |
MA (1) | MA18829A1 (en) |
NO (1) | NO801469L (en) |
NZ (1) | NZ193730A (en) |
OA (1) | OA06533A (en) |
PL (1) | PL224313A1 (en) |
PT (1) | PT71251A (en) |
ZA (1) | ZA802909B (en) |
ZW (1) | ZW11880A1 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507146A (en) * | 1982-12-28 | 1985-03-26 | Ciba-Geigy Corporation | 2,4-Diamino-6-halo-5-trifluoromethylpyrimidines having herbicidal activity |
DE3829469A1 (en) * | 1988-08-31 | 1990-03-01 | Bayer Ag | METHOD FOR THE PRODUCTION OF SUBSTITUTED N-AZINYL-N'-SULFONYL-ISOTHIO-UREAS AND N-AZINYL-IMINODITHIOCARBONIC ACID-S, S-DIESTER AS INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION |
EP0954316A4 (en) * | 1997-09-03 | 2002-02-13 | Lilly Co Eli | Pyrimidine derivatives |
CA2422371C (en) | 2000-09-15 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US20030105090A1 (en) | 2000-12-21 | 2003-06-05 | David Bebbington | Pyrazole compounds useful as protein kinase inhibitors |
CZ20032341A3 (en) * | 2001-01-31 | 2004-12-15 | Synaptic Pharmaceutical Corporation | Use of GAL3 receptor antagonists for treating depression and/or anxiety |
KR20040099324A (en) | 2002-03-13 | 2004-11-26 | 유로-셀티큐 에스.에이. | Aryl substituted pyrimidines and the use thereof |
US20040009981A1 (en) | 2002-03-15 | 2004-01-15 | David Bebbington | Compositions useful as inhibitors of protein kinases |
WO2003077656A1 (en) * | 2002-03-15 | 2003-09-25 | Ciba Specialty Chemicals Holding Inc. | 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces |
MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
CN101037438A (en) | 2002-08-02 | 2007-09-19 | 沃泰克斯药物股份有限公司 | Compositions useful as inhibitors of GSK-3 |
US7601718B2 (en) | 2003-02-06 | 2009-10-13 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
ATE542814T1 (en) | 2005-08-18 | 2012-02-15 | Vertex Pharma | PYRAZINE KINASE INHIBITORS |
BRPI0619708A2 (en) | 2005-11-03 | 2011-10-11 | Vertex Pharma | compound, composition, method for inhibiting aurora kinase activity in a biological sample, method for treating proliferative disorder and method for treating cancer |
AU2007317435A1 (en) | 2006-11-02 | 2008-05-15 | Vertex Pharmaceuticals Incorporated | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases |
NZ577768A (en) | 2006-12-19 | 2012-01-12 | Vertex Pharma | Aminopyrimidines useful as inhibitors of protein kinases |
ES2435997T3 (en) | 2007-03-09 | 2013-12-26 | Vertex Pharmaceuticals, Inc. | Aminopyrimidines useful as protein kinase inhibitors |
JP5393489B2 (en) | 2007-03-09 | 2014-01-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | Aminopyrimidines useful as inhibitors of protein kinases |
JP2010520887A (en) | 2007-03-09 | 2010-06-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Aminopyridines useful as inhibitors of protein kinases |
JP2010523700A (en) | 2007-04-13 | 2010-07-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | Aminopyrimidines useful as kinase inhibitors |
MX2009011810A (en) | 2007-05-02 | 2010-01-14 | Vertex Pharma | Thiazoles and pyrazoles useful as kinase inhibitors. |
WO2008137621A1 (en) | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
AR067762A1 (en) | 2007-07-31 | 2009-10-21 | Vertex Pharma | PROCESS TO PREPARE 5-FLUORO-1H-PIRAZOLO (3,4-B) PIRIDIN-3-AMINA AND DERIVATIVES OF THE SAME |
WO2010027921A1 (en) | 2008-09-03 | 2010-03-11 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical formulations comprising the same |
EP2364314B1 (en) * | 2008-12-09 | 2014-03-12 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
KR102328682B1 (en) * | 2018-08-27 | 2021-11-18 | 주식회사 대웅제약 | Novel heterocyclicamine derivatives and pharmaceutical composition comprising the same |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE754832A (en) * | 1969-08-14 | 1971-02-15 | Beecham Group Ltd | IMINAZOLINES |
-
1980
- 1980-05-05 MA MA19025A patent/MA18829A1/en unknown
- 1980-05-13 DD DD80221082A patent/DD150609A5/en unknown
- 1980-05-14 ES ES491514A patent/ES491514A0/en active Granted
- 1980-05-15 NZ NZ193730A patent/NZ193730A/en unknown
- 1980-05-15 IL IL60086A patent/IL60086A/en unknown
- 1980-05-16 NO NO801469A patent/NO801469L/en unknown
- 1980-05-16 FI FI801600A patent/FI801600A/en not_active Application Discontinuation
- 1980-05-16 IE IE1023/80A patent/IE49803B1/en unknown
- 1980-05-16 PT PT71251A patent/PT71251A/en unknown
- 1980-05-16 ZA ZA00802909A patent/ZA802909B/en unknown
- 1980-05-16 GB GB8016309A patent/GB2052487B/en not_active Expired
- 1980-05-16 DK DK214480A patent/DK214480A/en not_active Application Discontinuation
- 1980-05-16 ZW ZW118/80A patent/ZW11880A1/en unknown
- 1980-05-16 EP EP80102724A patent/EP0019811A1/en not_active Withdrawn
- 1980-05-16 AU AU58484/80A patent/AU5848480A/en not_active Abandoned
- 1980-05-16 GR GR61963A patent/GR68453B/el unknown
- 1980-05-17 OA OA57113A patent/OA06533A/en unknown
- 1980-05-17 KR KR1019800001944A patent/KR830002757A/en unknown
- 1980-05-17 JP JP6586380A patent/JPS55154971A/en active Pending
- 1980-05-17 PL PL22431380A patent/PL224313A1/xx unknown
- 1980-05-19 AR AR281109A patent/AR228256A1/en active
Also Published As
Publication number | Publication date |
---|---|
AU5848480A (en) | 1980-11-20 |
KR830002757A (en) | 1983-05-30 |
AR228256A1 (en) | 1983-02-15 |
PL224313A1 (en) | 1981-02-13 |
ZA802909B (en) | 1981-05-27 |
ZW11880A1 (en) | 1980-12-17 |
JPS55154971A (en) | 1980-12-02 |
PT71251A (en) | 1980-06-01 |
GB2052487A (en) | 1981-01-28 |
DD150609A5 (en) | 1981-09-09 |
GR68453B (en) | 1981-12-30 |
FI801600A (en) | 1980-11-19 |
DK214480A (en) | 1980-11-19 |
ES8104279A1 (en) | 1981-04-16 |
NZ193730A (en) | 1982-12-21 |
EP0019811A1 (en) | 1980-12-10 |
IE49803B1 (en) | 1985-12-25 |
OA06533A (en) | 1981-07-31 |
IL60086A0 (en) | 1980-07-31 |
GB2052487B (en) | 1983-05-11 |
MA18829A1 (en) | 1980-12-31 |
IL60086A (en) | 1984-03-30 |
ES491514A0 (en) | 1981-04-16 |
NO801469L (en) | 1980-11-19 |
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