ES8104279A1 - Procedimiento para la obtencion de nuevos compuestos de 2- (pirimidinilamino)-1,3-diaza-2-cicloalqueno - Google Patents

Procedimiento para la obtencion de nuevos compuestos de 2- (pirimidinilamino)-1,3-diaza-2-cicloalqueno

Info

Publication number
ES8104279A1
ES8104279A1 ES491514A ES491514A ES8104279A1 ES 8104279 A1 ES8104279 A1 ES 8104279A1 ES 491514 A ES491514 A ES 491514A ES 491514 A ES491514 A ES 491514A ES 8104279 A1 ES8104279 A1 ES 8104279A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
pyrimidine compounds
therapeutical use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491514A
Other languages
English (en)
Other versions
ES491514A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES491514A0 publication Critical patent/ES491514A0/es
Publication of ES8104279A1 publication Critical patent/ES8104279A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE 2-(PIRIMIDINALAMINO)-1,3-DIAZA-2-CICLOALQUENO, DE FORMULA (I), DONDE PY SIGNIFICA UN RESTO 4-O 5-PIRIMIDINILO; R1 Y R2 PUEDEN SER HIDROGENO, ALQUILO INFERIOR O ALQUENILO INFERIOR Y A1K PUEDE SER ALQUILENO INFERIOR. SE OBTIENE HACIENDO REACCIONAR DISTINTOS COMPUESTOS, COMO PUEDE SER EL DE FORMULA (V), CON PY-X O UN COMPUESTO DE FORMULA (VII), CON UN COMPUESTO ALQUILENDIAMINA DE FORMULA H2N-A1K-NHR1 O UN HALURO DE ACIDO FOSFINICO DE FORMULA (XII), CON UN COMPUESTO DE FORMULA PY-NH-R2; SIENDO Y, X, Y1 E Y2 DISTINTOS GRUPOS O RADICALES. ESTOS COMPUESTOS PRESENTAN INTERES FARMACOLOGICO. *FORMULA*
ES491514A 1979-05-18 1980-05-14 Procedimiento para la obtencion de nuevos compuestos de 2- (pirimidinilamino)-1,3-diaza-2-cicloalqueno Expired ES8104279A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH466979 1979-05-18

Publications (2)

Publication Number Publication Date
ES491514A0 ES491514A0 (es) 1981-04-16
ES8104279A1 true ES8104279A1 (es) 1981-04-16

Family

ID=4280399

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491514A Expired ES8104279A1 (es) 1979-05-18 1980-05-14 Procedimiento para la obtencion de nuevos compuestos de 2- (pirimidinilamino)-1,3-diaza-2-cicloalqueno

Country Status (21)

Country Link
EP (1) EP0019811A1 (es)
JP (1) JPS55154971A (es)
KR (1) KR830002757A (es)
AR (1) AR228256A1 (es)
AU (1) AU5848480A (es)
DD (1) DD150609A5 (es)
DK (1) DK214480A (es)
ES (1) ES8104279A1 (es)
FI (1) FI801600A (es)
GB (1) GB2052487B (es)
GR (1) GR68453B (es)
IE (1) IE49803B1 (es)
IL (1) IL60086A (es)
MA (1) MA18829A1 (es)
NO (1) NO801469L (es)
NZ (1) NZ193730A (es)
OA (1) OA06533A (es)
PL (1) PL224313A1 (es)
PT (1) PT71251A (es)
ZA (1) ZA802909B (es)
ZW (1) ZW11880A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507146A (en) * 1982-12-28 1985-03-26 Ciba-Geigy Corporation 2,4-Diamino-6-halo-5-trifluoromethylpyrimidines having herbicidal activity
DE3829469A1 (de) * 1988-08-31 1990-03-01 Bayer Ag Verfahren zur herstellung von substituierten n-azinyl-n'-sulfonyl-isothioharnstoffen und n-azinyl-iminodithiokohlensaeure-s,s-diester als zwischenprodukte zu ihrer herstellung
CA2269971A1 (en) * 1997-09-03 1999-03-11 Trent Lee Abraham Pyrimidine derivatives
US7473691B2 (en) 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
JP4922539B2 (ja) 2000-09-15 2012-04-25 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼインヒビターとして有用なピラゾール化合物
US6660731B2 (en) 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
NZ526470A (en) 2000-12-21 2006-03-31 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors
SK9562003A3 (en) * 2001-01-31 2004-04-06 Synaptic Pharma Corp Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
EP1483247B1 (en) 2002-03-13 2009-06-24 Euro-Celtique S.A. Aryl substituted pyrimidines and the use thereof
WO2003078427A1 (en) 2002-03-15 2003-09-25 Vertex Pharmaceuticals, Inc. Azolylaminoazines as inhibitors of protein kinases
JP2005520821A (ja) * 2002-03-15 2005-07-14 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド ４−アミノピリミジン及び表面の抗菌処理のためのその使用
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
AU2003257078B2 (en) 2002-08-02 2010-04-01 Vertex Pharmaceuticals Incorporated Pyrazole compositions useful as inhibitors of GSK-3
WO2004072029A2 (en) 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
WO2007022384A2 (en) 2005-08-18 2007-02-22 Vertex Pharmaceuticals Incorporated Pyrazine kinase inhibitors
EP1951715B1 (en) 2005-11-03 2013-09-04 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
ATE457311T1 (de) 2006-11-02 2010-02-15 Vertex Pharma Als inhibitoren von proteinkinasen geeignete aminopyridine und aminopyrimidine
EP2099787B1 (en) 2006-12-19 2010-07-21 Vertex Pharmaceuticals, Inc. Aminopyrimidines useful as inhibitors of protein kinases
KR20090120510A (ko) 2007-03-09 2009-11-24 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서 유용한 아미노피리미딘
CA2679701A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyridines useful as inhibitors of protein kinases
NZ579446A (en) 2007-03-09 2012-02-24 Vertex Pharma Aminopyrimidines useful as inhibitors of protein kinases
AU2008240313A1 (en) 2007-04-13 2008-10-23 Aj Park Aminopyrimidines useful as kinase inhibitors
CN101801959A (zh) 2007-05-02 2010-08-11 沃泰克斯药物股份有限公司 可用作激酶抑制剂的氨基嘧啶类化合物
EP2152694A2 (en) 2007-05-02 2010-02-17 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
AU2008282156B2 (en) 2007-07-31 2014-07-17 Vertex Pharmaceuticals Incorporated Process for preparing 5-fluoro-1H-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof
EP2323622A1 (en) 2008-09-03 2011-05-25 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical formulations comprising the same
PL2364314T3 (pl) * 2008-12-09 2014-08-29 Gilead Sciences Inc Modulatory receptorów Toll-podobnych
KR102328682B1 (ko) * 2018-08-27 2021-11-18 주식회사 대웅제약 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754832A (fr) * 1969-08-14 1971-02-15 Beecham Group Ltd Iminazolines

Also Published As

Publication number Publication date
ES491514A0 (es) 1981-04-16
FI801600A (fi) 1980-11-19
DK214480A (da) 1980-11-19
OA06533A (fr) 1981-07-31
KR830002757A (ko) 1983-05-30
GB2052487B (en) 1983-05-11
NO801469L (no) 1980-11-19
DD150609A5 (de) 1981-09-09
PL224313A1 (es) 1981-02-13
GB2052487A (en) 1981-01-28
IL60086A0 (en) 1980-07-31
EP0019811A1 (de) 1980-12-10
JPS55154971A (en) 1980-12-02
IE801023L (en) 1980-11-18
AU5848480A (en) 1980-11-20
IL60086A (en) 1984-03-30
PT71251A (en) 1980-06-01
IE49803B1 (en) 1985-12-25
GR68453B (es) 1981-12-30
ZA802909B (en) 1981-05-27
ZW11880A1 (en) 1980-12-17
NZ193730A (en) 1982-12-21
AR228256A1 (es) 1983-02-15
MA18829A1 (fr) 1980-12-31

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