ZA791047B - 2-hydroxymethyl-pyrazine derivatives and process for their preparation - Google Patents

2-hydroxymethyl-pyrazine derivatives and process for their preparation

Info

Publication number
ZA791047B
ZA791047B ZA791047A ZA791047A ZA791047B ZA 791047 B ZA791047 B ZA 791047B ZA 791047 A ZA791047 A ZA 791047A ZA 791047 A ZA791047 A ZA 791047A ZA 791047 B ZA791047 B ZA 791047B
Authority
ZA
South Africa
Prior art keywords
hydroxymethyl
preparation
pyrazine derivatives
pyrazine
derivatives
Prior art date
Application number
ZA791047A
Other languages
English (en)
Inventor
P Cozzi
L Bertone
O Magni
P Lovisolo
R Angelucci
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of ZA791047B publication Critical patent/ZA791047B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16—Halogen atoms; Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA791047A 1978-03-23 1979-03-06 2-hydroxymethyl-pyrazine derivatives and process for their preparation ZA791047B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21520/78A IT1094287B (it) 1978-03-23 1978-03-23 Derivati della 2-idrossimetil-pirazina aventi attivita' ipolipemizzante

Publications (1)

Publication Number Publication Date
ZA791047B true ZA791047B (en) 1980-03-26

Family

ID=11183025

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA791047A ZA791047B (en) 1978-03-23 1979-03-06 2-hydroxymethyl-pyrazine derivatives and process for their preparation

Country Status (13)

Country Link
US (1) US4267327A (de)
JP (1) JPS5531063A (de)
BE (1) BE875013A (de)
CA (1) CA1146171A (de)
CH (1) CH642639A5 (de)
DE (1) DE2910824A1 (de)
DK (1) DK151254C (de)
FR (2) FR2448536A1 (de)
GB (1) GB2017691B (de)
IT (1) IT1094287B (de)
NL (1) NL7902268A (de)
SE (1) SE446338B (de)
ZA (1) ZA791047B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406901A (en) * 1980-02-06 1983-09-27 Farmitalia Carlo Erba S.P.A. Ethers of substituted hydroxymethylpyrazines
IL64267A (en) * 1980-12-09 1985-08-30 Erba Farmitalia Ethers of hydroxymethylpyrazin-n-oxides,their preparation and pharmaceutical compositions containing them
JPS59219269A (ja) * 1983-05-30 1984-12-10 Terumo Corp ピラジン誘導体を有効成分とする血小板凝集抑制剤
DE3433960A1 (de) * 1984-09-15 1986-03-27 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von 2-amino-3-cyano-5-dialkoxymehtyl-pyrazinen und zwischenprodukte fuer diese verfahren
JPS63135216U (de) * 1987-02-27 1988-09-05
CN101684102B (zh) * 2008-09-28 2013-06-05 安徽省新星药物开发有限责任公司 苯氧乙酸吡嗪酯类衍生物及其制法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051245A (en) * 1972-04-28 1977-09-27 Carlo Erba, S.P.A. Pyrazine 4-oxide derivatives and process for their preparation
GB1361967A (en) * 1972-04-28 1974-07-30 Erba Carlo Spa Pyrazine 4-oxide derivatives and process for their preparation
US4002750A (en) * 1972-04-28 1977-01-11 Carlo Erba S.P.A. Pyrazine 4-oxide derivatives and process for their preparation

Also Published As

Publication number Publication date
FR2448536B1 (de) 1983-01-28
BE875013A (fr) 1979-09-24
DK118879A (da) 1979-09-24
IT7821520A0 (it) 1978-03-23
US4267327A (en) 1981-05-12
DK151254C (da) 1988-07-04
JPS6310697B2 (de) 1988-03-08
NL7902268A (nl) 1979-09-25
JPS5531063A (en) 1980-03-05
DE2910824C2 (de) 1989-06-22
FR2445144A1 (fr) 1980-07-25
GB2017691B (en) 1982-06-16
SE7902661L (sv) 1979-09-24
CA1146171A (en) 1983-05-10
IT1094287B (it) 1985-07-26
GB2017691A (en) 1979-10-10
FR2448536A1 (fr) 1980-09-05
DE2910824A1 (de) 1979-09-27
SE446338B (sv) 1986-09-01
CH642639A5 (de) 1984-04-30
FR2445144B1 (de) 1983-03-25
DK151254B (da) 1987-11-16

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