BE875013A - Nouveaux derives de 2-hydroxymethyl-pyrazine, utiles notamment comme hypolipemiants, et leur procede de preparation - Google Patents

Nouveaux derives de 2-hydroxymethyl-pyrazine, utiles notamment comme hypolipemiants, et leur procede de preparation

Info

Publication number
BE875013A
BE875013A BE0/194146A BE194146A BE875013A BE 875013 A BE875013 A BE 875013A BE 0/194146 A BE0/194146 A BE 0/194146A BE 194146 A BE194146 A BE 194146A BE 875013 A BE875013 A BE 875013A
Authority
BE
Belgium
Prior art keywords
hypolipemiants
pyrazine
hydroxymethyl
useful
preparation process
Prior art date
Application number
BE0/194146A
Other languages
English (en)
French (fr)
Inventor
P Cozzi
O Magni
L Bertone
R Angelucci
P P Lovisolo
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE875013A publication Critical patent/BE875013A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16—Halogen atoms; Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE0/194146A 1978-03-23 1979-03-22 Nouveaux derives de 2-hydroxymethyl-pyrazine, utiles notamment comme hypolipemiants, et leur procede de preparation BE875013A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21520/78A IT1094287B (it) 1978-03-23 1978-03-23 Derivati della 2-idrossimetil-pirazina aventi attivita' ipolipemizzante

Publications (1)

Publication Number Publication Date
BE875013A true BE875013A (fr) 1979-09-24

Family

ID=11183025

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/194146A BE875013A (fr) 1978-03-23 1979-03-22 Nouveaux derives de 2-hydroxymethyl-pyrazine, utiles notamment comme hypolipemiants, et leur procede de preparation

Country Status (13)

Country Link
US (1) US4267327A (xx)
JP (1) JPS5531063A (xx)
BE (1) BE875013A (xx)
CA (1) CA1146171A (xx)
CH (1) CH642639A5 (xx)
DE (1) DE2910824A1 (xx)
DK (1) DK151254C (xx)
FR (2) FR2448536A1 (xx)
GB (1) GB2017691B (xx)
IT (1) IT1094287B (xx)
NL (1) NL7902268A (xx)
SE (1) SE446338B (xx)
ZA (1) ZA791047B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406901A (en) * 1980-02-06 1983-09-27 Farmitalia Carlo Erba S.P.A. Ethers of substituted hydroxymethylpyrazines
IL64267A (en) * 1980-12-09 1985-08-30 Erba Farmitalia Ethers of hydroxymethylpyrazin-n-oxides,their preparation and pharmaceutical compositions containing them
JPS59219269A (ja) * 1983-05-30 1984-12-10 Terumo Corp ピラジン誘導体を有効成分とする血小板凝集抑制剤
DE3433960A1 (de) * 1984-09-15 1986-03-27 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von 2-amino-3-cyano-5-dialkoxymehtyl-pyrazinen und zwischenprodukte fuer diese verfahren
JPS63135216U (xx) * 1987-02-27 1988-09-05
CN101684102B (zh) * 2008-09-28 2013-06-05 安徽省新星药物开发有限责任公司 苯氧乙酸吡嗪酯类衍生物及其制法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051245A (en) * 1972-04-28 1977-09-27 Carlo Erba, S.P.A. Pyrazine 4-oxide derivatives and process for their preparation
GB1361967A (en) * 1972-04-28 1974-07-30 Erba Carlo Spa Pyrazine 4-oxide derivatives and process for their preparation
US4002750A (en) * 1972-04-28 1977-01-11 Carlo Erba S.P.A. Pyrazine 4-oxide derivatives and process for their preparation

Also Published As

Publication number Publication date
FR2448536B1 (xx) 1983-01-28
DK118879A (da) 1979-09-24
IT7821520A0 (it) 1978-03-23
US4267327A (en) 1981-05-12
DK151254C (da) 1988-07-04
JPS6310697B2 (xx) 1988-03-08
NL7902268A (nl) 1979-09-25
JPS5531063A (en) 1980-03-05
DE2910824C2 (xx) 1989-06-22
FR2445144A1 (fr) 1980-07-25
GB2017691B (en) 1982-06-16
SE7902661L (sv) 1979-09-24
CA1146171A (en) 1983-05-10
IT1094287B (it) 1985-07-26
GB2017691A (en) 1979-10-10
ZA791047B (en) 1980-03-26
FR2448536A1 (fr) 1980-09-05
DE2910824A1 (de) 1979-09-27
SE446338B (sv) 1986-09-01
CH642639A5 (de) 1984-04-30
FR2445144B1 (xx) 1983-03-25
DK151254B (da) 1987-11-16

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19920331