ZA201204940B - Co-crystals of a triazolo [4,5-d] pyrimidine platelet aggregation inhibitor - Google Patents

Co-crystals of a triazolo [4,5-d] pyrimidine platelet aggregation inhibitor

Info

Publication number
ZA201204940B
ZA201204940B ZA2012/04940A ZA201204940A ZA201204940B ZA 201204940 B ZA201204940 B ZA 201204940B ZA 2012/04940 A ZA2012/04940 A ZA 2012/04940A ZA 201204940 A ZA201204940 A ZA 201204940A ZA 201204940 B ZA201204940 B ZA 201204940B
Authority
ZA
South Africa
Prior art keywords
triazolo
pyrimidine
crystals
platelet aggregation
aggregation inhibitor
Prior art date
Application number
ZA2012/04940A
Other languages
English (en)
Inventor
Stephen David Cosgrove
Anna Polyakova-Akkus
Brenton Skylar Wolfe
Matthew Jonathan Jones
Valeriya Nikolayevna Smolenskaya
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA201204940B publication Critical patent/ZA201204940B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA2012/04940A 2009-12-03 2012-07-02 Co-crystals of a triazolo [4,5-d] pyrimidine platelet aggregation inhibitor ZA201204940B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26630709P 2009-12-03 2009-12-03
PCT/GB2010/002222 WO2011067571A1 (fr) 2009-12-03 2010-12-03 Co-cristaux d'un inhibiteur d'agrégation plaquettaire à base de triazolo [4,5-d] pyrimidine

Publications (1)

Publication Number Publication Date
ZA201204940B true ZA201204940B (en) 2013-03-27

Family

ID=43535876

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2012/04940A ZA201204940B (en) 2009-12-03 2012-07-02 Co-crystals of a triazolo [4,5-d] pyrimidine platelet aggregation inhibitor

Country Status (12)

Country Link
US (1) US8883802B2 (fr)
EP (1) EP2507242A1 (fr)
JP (1) JP2013512886A (fr)
KR (1) KR20120123659A (fr)
CN (2) CN104230936A (fr)
AU (1) AU2010326361A1 (fr)
BR (1) BR112012013365A2 (fr)
CA (1) CA2781182A1 (fr)
MX (1) MX2012006375A (fr)
RU (1) RU2012126029A (fr)
WO (1) WO2011067571A1 (fr)
ZA (1) ZA201204940B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2013014035A (es) * 2011-06-01 2014-01-23 Astrazeneca Ab Nuevo co-cristal ticagrelor.
WO2013150495A2 (fr) 2012-04-05 2013-10-10 Dr. Reddy's Laboratories Limited Préparation de ticagrelor
WO2013186726A2 (fr) * 2012-06-15 2013-12-19 Basf Se Cristaux à plusieurs composants comprenant du dasatinib et des agents de formation de cocristaux choisis
EA024825B8 (ru) * 2012-06-29 2016-12-30 Зентива, К.С. Сокристалл тикагрелора с 3-гидрокси-2-нафтойной кислотой, способ его получения и применение
CA2877541C (fr) 2012-07-04 2020-06-30 Lek Pharmaceuticals D.D. Produits d'addition de ticagrelor et de sels metalliques divalents
CZ2012705A3 (cs) 2012-10-16 2014-04-23 Zentiva, K.S. Pevná orální farmaceutická formulace obsahující ticagrelor
MX2015013059A (es) * 2013-03-15 2016-08-05 Bionomics Ltd Sales, co-cristales, y polimorfos de un compuesto ansiolitico.
WO2014170026A1 (fr) 2013-04-18 2014-10-23 Zentiva, K.S. Ticagrelor amorphe stabilisé
EP2813216A1 (fr) 2013-06-10 2014-12-17 Zentiva, a.s. Ticagrelor amorphe stabilisé
CN104341423B (zh) * 2013-08-02 2017-03-01 上海京新生物医药有限公司 替格瑞洛的一水合物及其制备方法与在制药中的应用
CZ2013866A3 (cs) 2013-11-08 2015-05-20 Zentiva, K.S. Způsob výroby a nová krystalická forma intermediátu syntézy ticagreloru
CN103601726B (zh) * 2013-12-02 2016-09-28 浙江大学 两种替格瑞洛药物共晶及其制备方法
WO2015183801A1 (fr) 2014-05-27 2015-12-03 R. J. Reynolds Tobacco Company Sels, co-cristaux, et complexes de co-cristaux de sels de nicotine
US9896429B2 (en) 2014-05-27 2018-02-20 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
US10508096B2 (en) 2014-05-27 2019-12-17 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
WO2016116942A1 (fr) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Nouveaux composés pharmaceutiques comprenant du ticagrélor avec des sels d'aspirine
CN108495563B (zh) 2015-11-25 2022-04-26 R.J.雷诺兹烟草公司 烟碱盐、共晶体和盐共晶体配合物
CA3009610C (fr) 2015-12-24 2024-02-13 Takeda Pharmaceutical Company Limited Cocristal de (s)(1-((1-acryloylpyrrolidine-3-yl)oxy)isoquinoline-3-yl)-1h-1,2,4-triazole-5(4h)-one, methode de production et composition pharmaceutique comprenant le cocristal
US10905691B2 (en) 2016-09-09 2021-02-02 Université de Liège Use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection
EP3292867B1 (fr) * 2016-09-09 2019-05-15 Université de Liège Dérivés triazolo(4,5-d)pyrimidines pour la prevention et le traitement d'infections bacteriennes
WO2019049049A1 (fr) 2017-09-05 2019-03-14 R. J. Reynolds Tobacco Company Sels, co-cristaux, et complexes de co-cristaux de sels de nicotine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017014A1 (es) 1997-07-22 2001-08-22 Astrazeneca Ab Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
SE0101932D0 (sv) * 2001-05-31 2001-05-31 Astrazeneca Ab Pharmaceutical combinations

Also Published As

Publication number Publication date
MX2012006375A (es) 2013-03-21
CA2781182A1 (fr) 2011-06-09
CN104230936A (zh) 2014-12-24
CN102770434A (zh) 2012-11-07
JP2013512886A (ja) 2013-04-18
AU2010326361A1 (en) 2012-06-07
KR20120123659A (ko) 2012-11-09
BR112012013365A2 (pt) 2016-03-01
US20130040970A1 (en) 2013-02-14
US8883802B2 (en) 2014-11-11
EP2507242A1 (fr) 2012-10-10
WO2011067571A1 (fr) 2011-06-09
RU2012126029A (ru) 2014-01-10

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