ZA201201259B - Nitroimidazooxazine and nitroimidazooxazole analogues and their uses - Google Patents
Nitroimidazooxazine and nitroimidazooxazole analogues and their usesInfo
- Publication number
- ZA201201259B ZA201201259B ZA2012/01259A ZA201201259A ZA201201259B ZA 201201259 B ZA201201259 B ZA 201201259B ZA 2012/01259 A ZA2012/01259 A ZA 2012/01259A ZA 201201259 A ZA201201259 A ZA 201201259A ZA 201201259 B ZA201201259 B ZA 201201259B
- Authority
- ZA
- South Africa
- Prior art keywords
- nitroimidazooxazine
- nitroimidazooxazole
- analogues
- nitroimidazooxazole analogues
- Prior art date
Links
- RJLPZNLNSQCJHV-UHFFFAOYSA-N 2-nitro-2h-imidazo[4,5-d][1,3]oxazole Chemical class C1=NC2=NC([N+](=O)[O-])OC2=N1 RJLPZNLNSQCJHV-UHFFFAOYSA-N 0.000 title 1
- YVMGQODAKAHLHB-UHFFFAOYSA-N 3-nitroimidazo[4,5-e]oxazine Chemical compound O1N=C([N+](=O)[O-])C=C2N=CN=C21 YVMGQODAKAHLHB-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Pulmonology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23042209P | 2009-07-31 | 2009-07-31 | |
| PCT/US2010/043908 WO2011014776A1 (en) | 2009-07-31 | 2010-07-30 | Nitroimidazooxazine and nitroimidazooxazole analogues and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201201259B true ZA201201259B (en) | 2013-08-28 |
Family
ID=42829983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2012/01259A ZA201201259B (en) | 2009-07-31 | 2012-02-20 | Nitroimidazooxazine and nitroimidazooxazole analogues and their uses |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8293734B2 (OSRAM) |
| EP (1) | EP2459570B1 (OSRAM) |
| JP (1) | JP5685254B2 (OSRAM) |
| KR (1) | KR101738868B1 (OSRAM) |
| CN (1) | CN102741259B (OSRAM) |
| AU (1) | AU2010278779B2 (OSRAM) |
| BR (1) | BR112012002214B1 (OSRAM) |
| CA (1) | CA2769263C (OSRAM) |
| ES (1) | ES2530266T3 (OSRAM) |
| NZ (1) | NZ598165A (OSRAM) |
| RU (1) | RU2540860C2 (OSRAM) |
| WO (1) | WO2011014776A1 (OSRAM) |
| ZA (1) | ZA201201259B (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201012209D0 (en) * | 2010-05-31 | 2010-09-08 | Ge Healthcare Ltd | In vivo imaging agent |
| JP5916739B2 (ja) * | 2011-04-15 | 2016-05-11 | 大塚製薬株式会社 | ６，７−ジヒドロイミダゾ［２，１−ｂ］［１，３］オキサジン化合物 |
| JP2015006994A (ja) * | 2011-10-28 | 2015-01-15 | 大正製薬株式会社 | ジヒドロイミダゾオキサゾール誘導体 |
| KR101918469B1 (ko) * | 2012-06-04 | 2018-11-15 | 한국화학연구원 | 바이사이클릭 니트로이미다졸 유도체 또는 이들의 광학이성질체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물 |
| US10301294B2 (en) * | 2013-03-13 | 2019-05-28 | The Broad Institute Inc. | Compounds for the treatment of tuberculosis |
| CN104059082B (zh) * | 2013-03-21 | 2016-08-03 | 苏州迈泰生物技术有限公司 | 硝基咪唑杂环类化合物及其在制备治疗结核病药物中的应用 |
| KR101564425B1 (ko) | 2013-11-26 | 2015-10-30 | 한국화학연구원 | 신규한 바이사이클릭 니트로이미다졸 카바메이트 화합물, 이를 제조하는 방법 및 이를 유효성분으로 함유하는 결핵 질환의 예방 또는 치료용 약제학적 조성물 |
| TWI687409B (zh) | 2014-08-28 | 2020-03-11 | 日商大塚製藥股份有限公司 | 稠合雜環化合物 |
| KR101682356B1 (ko) | 2014-11-04 | 2016-12-06 | 한국화학연구원 | 이미다조 옥사진 유도체, 이의 약학적으로 허용 가능한 염 또는 이의 광학이성질체 및 이를 유효성분으로 함유하는 약제학적 조성물 |
| WO2016119706A1 (zh) | 2015-01-29 | 2016-08-04 | 南京明德新药研发股份有限公司 | 抗肺结核病的硝基咪唑衍生物 |
| GB201519054D0 (en) * | 2015-10-28 | 2015-12-09 | Univ Dundee | Composition |
| JP6905506B2 (ja) | 2016-02-26 | 2021-07-21 | 大塚製薬株式会社 | ピペリジン誘導体 |
| CN108727406B (zh) | 2017-03-28 | 2021-12-07 | 北京协和制药二厂 | 含氮杂环取代的苯并噁嗪噁唑烷酮类化合物及其制备方法和用途 |
| WO2020223267A1 (en) * | 2019-05-01 | 2020-11-05 | Boehringer Ingelheim International Gmbh | (r)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate |
| KR20240122521A (ko) | 2021-12-14 | 2024-08-12 | 베링거 인겔하임 인터내셔날 게엠베하 | 만성 신장 질환 치료용 알도스테론 신타아제 억제제 |
| CN114249747A (zh) * | 2021-12-27 | 2022-03-29 | 苏州虞美景盛新药开发有限公司 | 一种用于治疗广泛耐药性结核病的硝基咪唑吡喃类药物的新合成工艺 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL41744A0 (en) | 1972-03-16 | 1973-05-31 | Ciba Geigy Ag | New aryl ether derivatives,their production and their use as pesticides |
| CH568715A5 (OSRAM) | 1972-03-16 | 1975-11-14 | Ciba Geigy Ag | |
| FR2575158B1 (fr) | 1984-12-20 | 1987-10-02 | Pf Medicament | Arylalcoyloxymethyl-2 morpholines, leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central |
| SU1271861A1 (ru) * | 1985-05-07 | 1986-11-23 | Иркутский институт органической химии СО АН СССР | Способ получени 2,2-диметил-3-цианометилиденбензимидазо @ 2,1- @ -1,3-оксазолидина |
| US5668127A (en) * | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
| US6087358A (en) | 1995-06-26 | 2000-07-11 | Pathogenesis Corporation | Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof |
| AR041198A1 (es) * | 2002-10-11 | 2005-05-04 | Otsuka Pharma Co Ltd | Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen |
| CA2539335A1 (en) * | 2003-10-31 | 2005-05-12 | Otsuka Pharmaceutical Co., Ltd. | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis |
| JP4787529B2 (ja) | 2004-04-09 | 2011-10-05 | 大塚製薬株式会社 | 医薬組成物 |
| JP4789966B2 (ja) | 2004-04-09 | 2011-10-12 | 大塚製薬株式会社 | 医薬組成物 |
| EP1650211B1 (en) | 2004-09-17 | 2011-09-14 | Daiso Co., Ltd. | Process for preparing imidazopyran derivatives |
| ATE529430T1 (de) * | 2005-07-28 | 2011-11-15 | Vertex Pharma | Caspase-hemmer-propharmaka |
| KR20080079280A (ko) | 2005-12-23 | 2008-08-29 | 노파르티스 아게 | 니트로이미다졸 화합물 |
| US20070213341A1 (en) | 2006-03-13 | 2007-09-13 | Li Chen | Spiroindolinone derivatives |
| WO2008008480A2 (en) | 2006-07-12 | 2008-01-17 | Cumbre Pharmaceuticals Inc. | Nitroheteroaryl-containing rifamycin derivatives |
| NZ579431A (en) | 2007-03-09 | 2012-04-27 | Sanofi Aventis | Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof |
| US7666864B2 (en) | 2008-03-26 | 2010-02-23 | Global Alliance For Tb Drug Development | Bicyclic nitroimidazole-substituted phenyl oxazolidinones |
-
2010
- 2010-07-30 CN CN201080041655.3A patent/CN102741259B/zh not_active Expired - Fee Related
- 2010-07-30 AU AU2010278779A patent/AU2010278779B2/en not_active Ceased
- 2010-07-30 RU RU2012107180/04A patent/RU2540860C2/ru active
- 2010-07-30 KR KR1020127005331A patent/KR101738868B1/ko not_active Expired - Fee Related
- 2010-07-30 WO PCT/US2010/043908 patent/WO2011014776A1/en not_active Ceased
- 2010-07-30 US US12/847,459 patent/US8293734B2/en not_active Expired - Fee Related
- 2010-07-30 CA CA2769263A patent/CA2769263C/en active Active
- 2010-07-30 EP EP10740807.2A patent/EP2459570B1/en active Active
- 2010-07-30 BR BR112012002214-8A patent/BR112012002214B1/pt not_active IP Right Cessation
- 2010-07-30 JP JP2012523088A patent/JP5685254B2/ja not_active Expired - Fee Related
- 2010-07-30 ES ES10740807.2T patent/ES2530266T3/es active Active
- 2010-07-30 NZ NZ598165A patent/NZ598165A/xx not_active IP Right Cessation
-
2012
- 2012-02-20 ZA ZA2012/01259A patent/ZA201201259B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120084714A (ko) | 2012-07-30 |
| RU2012107180A (ru) | 2013-09-10 |
| JP2013500997A (ja) | 2013-01-10 |
| AU2010278779A1 (en) | 2012-03-08 |
| EP2459570B1 (en) | 2014-12-24 |
| JP5685254B2 (ja) | 2015-03-18 |
| US8293734B2 (en) | 2012-10-23 |
| KR101738868B1 (ko) | 2017-05-23 |
| US20110028466A1 (en) | 2011-02-03 |
| CA2769263C (en) | 2017-03-07 |
| CA2769263A1 (en) | 2011-02-03 |
| EP2459570A1 (en) | 2012-06-06 |
| AU2010278779B2 (en) | 2014-08-14 |
| CN102741259A (zh) | 2012-10-17 |
| CN102741259B (zh) | 2016-04-13 |
| BR112012002214B1 (pt) | 2022-01-25 |
| WO2011014776A1 (en) | 2011-02-03 |
| RU2540860C2 (ru) | 2015-02-10 |
| NZ598165A (en) | 2013-05-31 |
| ES2530266T3 (es) | 2015-02-27 |
| BR112012002214A2 (pt) | 2020-08-18 |
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