ZA201006589B - Bridged heterocycles as hiv integrase inhibitors - Google Patents

Bridged heterocycles as hiv integrase inhibitors

Info

Publication number
ZA201006589B
ZA201006589B ZA2010/06589A ZA201006589A ZA201006589B ZA 201006589 B ZA201006589 B ZA 201006589B ZA 2010/06589 A ZA2010/06589 A ZA 2010/06589A ZA 201006589 A ZA201006589 A ZA 201006589A ZA 201006589 B ZA201006589 B ZA 201006589B
Authority
ZA
South Africa
Prior art keywords
hiv integrase
integrase inhibitors
bridged heterocycles
heterocycles
bridged
Prior art date
Application number
ZA2010/06589A
Other languages
English (en)
Inventor
Francis Beaulieu
Carl Ouellet
B Narasimhulu Naidu
Manoj Patel
Yasutsugu Ueda
Timothy P Connolly
Jonathan R Weiss
Michael A Walker
Nicholas A Meanwell
Kevin M Peese
Margaret E Sorenson
Chen Li
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA201006589B publication Critical patent/ZA201006589B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA2010/06589A 2008-03-19 2010-09-14 Bridged heterocycles as hiv integrase inhibitors ZA201006589B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3772908P 2008-03-19 2008-03-19
US12/406,268 US8129398B2 (en) 2008-03-19 2009-03-18 HIV integrase inhibitors
PCT/US2009/037596 WO2009117540A1 (en) 2008-03-19 2009-03-19 Bridged heterocycles as hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
ZA201006589B true ZA201006589B (en) 2012-02-29

Family

ID=40863725

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2010/06589A ZA201006589B (en) 2008-03-19 2010-09-14 Bridged heterocycles as hiv integrase inhibitors

Country Status (15)

Country Link
US (1) US8129398B2 (enExample)
EP (1) EP2280981B8 (enExample)
JP (1) JP2011515412A (enExample)
KR (1) KR20100137522A (enExample)
CN (1) CN102036996A (enExample)
AU (1) AU2009225577A1 (enExample)
BR (1) BRPI0910307A2 (enExample)
CA (1) CA2718950A1 (enExample)
CO (1) CO6331439A2 (enExample)
EA (1) EA201001508A1 (enExample)
IL (1) IL208068A0 (enExample)
MX (1) MX2010009995A (enExample)
NZ (1) NZ588031A (enExample)
WO (1) WO2009117540A1 (enExample)
ZA (1) ZA201006589B (enExample)

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WO2015171398A1 (en) 2014-05-05 2015-11-12 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
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JP6672176B2 (ja) 2014-05-19 2020-03-25 レンペックス・ファーマシューティカルズ・インコーポレイテッド ボロン酸誘導体およびその治療的使用
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
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HUE059677T2 (hu) * 2019-03-22 2022-12-28 Gilead Sciences Inc Áthidalt triciklusos karbamoilpiridon-vegyületek és ezek gyógyszerészeti alkalmazása
CR20220418A (es) 2020-02-24 2022-10-10 Gilead Sciences Inc Compuestos tetracíclicos para el tratamiento de infecciones por vih
JP7691494B2 (ja) 2020-09-30 2025-06-11 ギリアード サイエンシーズ， インコーポレイテッド 架橋三環式カルバモイルピリドン化合物及びその使用
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Also Published As

Publication number Publication date
JP2011515412A (ja) 2011-05-19
US20090253677A1 (en) 2009-10-08
CA2718950A1 (en) 2009-09-24
MX2010009995A (es) 2010-09-30
EP2280981A1 (en) 2011-02-09
KR20100137522A (ko) 2010-12-30
WO2009117540A1 (en) 2009-09-24
CO6331439A2 (es) 2011-10-20
AU2009225577A1 (en) 2009-09-24
EP2280981B8 (en) 2014-09-17
EP2280981B1 (en) 2014-04-23
BRPI0910307A2 (pt) 2019-09-24
NZ588031A (en) 2011-12-22
EA201001508A1 (ru) 2011-04-29
CN102036996A (zh) 2011-04-27
US8129398B2 (en) 2012-03-06
IL208068A0 (en) 2010-12-30

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