ZA201001644B - Use of slit,nephrin,ephrin or semaphorin for treatment of cartilage diseases - Google Patents
Use of slit,nephrin,ephrin or semaphorin for treatment of cartilage diseasesInfo
- Publication number
- ZA201001644B ZA201001644B ZA2010/01644A ZA201001644A ZA201001644B ZA 201001644 B ZA201001644 B ZA 201001644B ZA 2010/01644 A ZA2010/01644 A ZA 2010/01644A ZA 201001644 A ZA201001644 A ZA 201001644A ZA 201001644 B ZA201001644 B ZA 201001644B
- Authority
- ZA
- South Africa
- Prior art keywords
- nephrin
- semaphorin
- ephrin
- slit
- treatment
- Prior art date
Links
- VYLJAYXZTOTZRR-BTPDVQIOSA-N CC(C)(O)[C@H]1CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@@]3(C)CCCC(C)(C)[C@@H]3[C@@H](O)[C@H](O)[C@@]12C Chemical compound CC(C)(O)[C@H]1CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@@]3(C)CCCC(C)(C)[C@@H]3[C@@H](O)[C@H](O)[C@@]12C VYLJAYXZTOTZRR-BTPDVQIOSA-N 0.000 title 1
- 102100023195 Nephrin Human genes 0.000 title 1
- 102000014105 Semaphorin Human genes 0.000 title 1
- 108050003978 Semaphorin Proteins 0.000 title 1
- 208000015100 cartilage disease Diseases 0.000 title 1
- 108060002566 ephrin Proteins 0.000 title 1
- 102000012803 ephrin Human genes 0.000 title 1
- VYLJAYXZTOTZRR-UHFFFAOYSA-N hopane-6alpha,7beta,22-triol Natural products C12CCC3C4(C)CCCC(C)(C)C4C(O)C(O)C3(C)C1(C)CCC1C2(C)CCC1C(C)(O)C VYLJAYXZTOTZRR-UHFFFAOYSA-N 0.000 title 1
- 108010027531 nephrin Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07018131A EP2036921A1 (en) | 2007-09-14 | 2007-09-14 | Use of Slit, nephrin, ephrin or semaphorin for treatment of cartilage diseases |
| EP08006810 | 2008-04-03 | ||
| PCT/EP2008/007579 WO2009033715A2 (en) | 2007-09-14 | 2008-09-12 | Neuroendocrine factors for treatment of degenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201001644B true ZA201001644B (en) | 2011-03-30 |
Family
ID=40452588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2010/01644A ZA201001644B (en) | 2007-09-14 | 2010-03-08 | Use of slit,nephrin,ephrin or semaphorin for treatment of cartilage diseases |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110002972A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2212344B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010539123A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100075493A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101821283A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008297889A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0816784A8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2699411A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010002716A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ583851A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2496790C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009033715A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201001644B (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1400024B1 (it) * | 2010-05-21 | 2013-05-17 | Uni Politecnica Delle Marche | Uso farmaceutico di semaforine. |
| UY33833A (es) * | 2010-12-23 | 2012-07-31 | Sanofi Sa | Proteína de fusión Robo1-Fc para su uso en el tratamiento del hepatocarcinoma |
| ES3013463T3 (en) * | 2011-07-04 | 2025-04-14 | Mesoblast Inc | Treating or preventing rheumatic disease |
| CN104582727B (zh) * | 2012-06-15 | 2018-04-27 | 财团法人峩山社会福祉财团 | 利用Slit-Robo系统用于预防或治疗骨折或骨质疏松症的组合物 |
| ES2442242B1 (es) * | 2012-08-09 | 2014-11-25 | Biotechnology Institute, I Mas D, S.L. | Composición con factores de crecimiento destinada al tratamiento intranasal de una enfermedad neurodegenerativa u otra patología del sistema nervioso central, y su método de fabricación. |
| CN104119448A (zh) * | 2013-04-26 | 2014-10-29 | 李华顺 | 含有富含亮氨酸重复序列的融合蛋白及其制法和应用 |
| CN104119445A (zh) * | 2013-04-26 | 2014-10-29 | 李华顺 | 含有富含亮氨酸重复序列的融合蛋白及其制法和应用 |
| CN104119447A (zh) * | 2013-04-26 | 2014-10-29 | 李华顺 | 含有富含亮氨酸重复序列的融合蛋白及其制法和应用 |
| CN104119446A (zh) * | 2013-04-26 | 2014-10-29 | 李华顺 | 含有富含亮氨酸重复序列的融合蛋白及其制法和应用 |
| WO2015072527A1 (ja) * | 2013-11-13 | 2015-05-21 | 国立大学法人大阪大学 | ネトリン１含有破骨細胞形成抑制剤 |
| HUE068789T2 (hu) | 2014-03-14 | 2025-01-28 | Univ New York State Res Found | A csontnövekedés és a csontlebontás neurogén szabályozása |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| US20200397860A1 (en) * | 2018-02-14 | 2020-12-24 | Cornell University | Slit and bone growth modulation |
| KR102353524B1 (ko) * | 2019-02-27 | 2022-01-20 | 주식회사 대웅제약 | 알부민이 결합된, Slit3 단백질의 LRRD2를 포함하는 골 관련 질환 예방 또는 치료용 조성물 |
| US20220340643A1 (en) * | 2019-09-13 | 2022-10-27 | Rutgers, The State University Of New Jersey | Aav-compatible laminin-linker polymerization proteins |
| CN110841057B (zh) * | 2019-11-19 | 2023-08-01 | 四川大学华西医院 | 一种神经导向因子Sema在制备治疗骨关节炎巴布膏剂中的应用 |
| CN110721308B (zh) * | 2019-11-19 | 2023-08-01 | 四川大学华西医院 | 一种用于治疗骨关节炎的药物复方制剂及其制备方法 |
| CN110772632B (zh) * | 2019-11-19 | 2023-08-11 | 四川大学华西医院 | 神经导向因子semaphorin 3a在制备治疗骨关节炎药物中的用途 |
| CN110694051B (zh) * | 2019-11-19 | 2023-08-01 | 四川大学华西医院 | 一种神经导向因子Sema在制备治疗骨关节炎注射剂中的应用 |
| CN110711244B (zh) * | 2019-11-19 | 2023-08-01 | 四川大学华西医院 | 一种神经导向因子Sema在制备治疗骨关节炎搽剂中的应用 |
| CN110684805B (zh) * | 2019-11-19 | 2023-08-01 | 四川大学华西医院 | 神经导向因子Sema基因重组慢病毒载体在制备治疗骨关节炎药物中的应用 |
| US20240277861A1 (en) * | 2021-07-26 | 2024-08-22 | Purotech Bio, Inc. | Anti-hepatitis b virus agent targeting host factor lipg |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2700117B1 (fr) * | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens. |
| JPH1116490A (ja) * | 1997-06-26 | 1999-01-22 | Kyocera Corp | プラズマディスプレイパネル用隔壁の製造方法及びプラズマディスプレイパネル用基板 |
| US20030032057A1 (en) * | 1997-08-26 | 2003-02-13 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6342370B1 (en) * | 1997-10-31 | 2002-01-29 | Osiris Therapeutics, Inc. | Human slit polypeptide and polynucleotides encoding same |
| JPH11164690A (ja) * | 1997-12-05 | 1999-06-22 | Asahi Chem Ind Co Ltd | 脊椎動物スリット蛋白質 |
| US6924355B2 (en) * | 1998-09-01 | 2005-08-02 | Genentech, Inc. | PRO1343 polypeptides |
| EP1163336A2 (en) * | 1999-03-17 | 2001-12-19 | Washington University | Vertebrate protein slit, dna sequence encoding it and uses thereof |
| WO2002006315A2 (en) * | 2000-07-18 | 2002-01-24 | Compugen Ltd. | Novel nucleic acid and amino acid sequences |
| WO2002010217A2 (en) * | 2000-08-02 | 2002-02-07 | The Johns Hopkins University | Endothelial cell expression patterns |
| WO2002012346A2 (en) * | 2000-08-10 | 2002-02-14 | Pharmacia Corporation | A new slit-like protein obtained from a cdna library from hs-5 stromal cell line |
| WO2002081745A2 (en) * | 2001-04-05 | 2002-10-17 | Proskelia Pharmaceuticals | Genes involved in osteogenesis, and methods of use |
| US20050014680A1 (en) * | 2003-04-15 | 2005-01-20 | Crabtree Gerald R. | Methods and compositions for enhancing neuron growth and survival |
| US20060025335A1 (en) * | 2004-01-30 | 2006-02-02 | Kinane Thomas B | Netrin compositions and methods of using the same |
| BRPI0720038A2 (pt) * | 2006-12-11 | 2013-12-24 | Univ Utah Res Found | Métodos para inibir a permeabilidade vascular em tecido, para triar ou avaliar um agente que inibe a permeabilidade vascular, para tratar ou prevenir a síndrome da angústia respiratória, a retinopatia de prematuridade, a retinopatia diabética e a degeneração macular úmida em um indivíduo, para tratar indivíduos com sugestões repulsivas ou miméticos e para promover a angiogênese em um tecido, polipeptídeo isolado, ácido nucleico isolado, e, vetor |
-
2008
- 2008-09-12 AU AU2008297889A patent/AU2008297889A1/en not_active Abandoned
- 2008-09-12 BR BRPI0816784A patent/BRPI0816784A8/pt not_active IP Right Cessation
- 2008-09-12 CN CN200880111279A patent/CN101821283A/zh active Pending
- 2008-09-12 MX MX2010002716A patent/MX2010002716A/es not_active Application Discontinuation
- 2008-09-12 RU RU2010114713/10A patent/RU2496790C2/ru not_active IP Right Cessation
- 2008-09-12 JP JP2010524408A patent/JP2010539123A/ja active Pending
- 2008-09-12 CA CA2699411A patent/CA2699411A1/en not_active Abandoned
- 2008-09-12 US US12/677,830 patent/US20110002972A1/en not_active Abandoned
- 2008-09-12 NZ NZ583851A patent/NZ583851A/en not_active IP Right Cessation
- 2008-09-12 EP EP08802131.6A patent/EP2212344B1/en active Active
- 2008-09-12 KR KR1020107007806A patent/KR20100075493A/ko not_active Withdrawn
- 2008-09-12 WO PCT/EP2008/007579 patent/WO2009033715A2/en not_active Ceased
-
2010
- 2010-03-08 ZA ZA2010/01644A patent/ZA201001644B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0816784A8 (pt) | 2016-01-19 |
| MX2010002716A (es) | 2010-07-05 |
| EP2212344A2 (en) | 2010-08-04 |
| AU2008297889A1 (en) | 2009-03-19 |
| RU2496790C2 (ru) | 2013-10-27 |
| CA2699411A1 (en) | 2009-03-19 |
| NZ583851A (en) | 2012-06-29 |
| WO2009033715A2 (en) | 2009-03-19 |
| KR20100075493A (ko) | 2010-07-02 |
| JP2010539123A (ja) | 2010-12-16 |
| EP2212344B1 (en) | 2014-03-26 |
| RU2010114713A (ru) | 2011-10-20 |
| BRPI0816784A2 (pt) | 2015-03-24 |
| CN101821283A (zh) | 2010-09-01 |
| US20110002972A1 (en) | 2011-01-06 |
| WO2009033715A3 (en) | 2010-03-18 |
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