ZA201001546B - Isoxazole compounds for the treatment of cancer - Google Patents

Isoxazole compounds for the treatment of cancer

Info

Publication number
ZA201001546B
ZA201001546B ZA201001546A ZA201001546A ZA201001546B ZA 201001546 B ZA201001546 B ZA 201001546B ZA 201001546 A ZA201001546 A ZA 201001546A ZA 201001546 A ZA201001546 A ZA 201001546A ZA 201001546 B ZA201001546 B ZA 201001546B
Authority
ZA
South Africa
Prior art keywords
cancer
treatment
isoxazole compounds
isoxazole
compounds
Prior art date
Application number
ZA201001546A
Other languages
English (en)
Inventor
Patrick Chene
Carlos Garcia-Echeverria
Michael Rugaard Jensen
Cornelia Quadt
Thomas Radimerski
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA201001546B publication Critical patent/ZA201001546B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA201001546A 2007-10-12 2010-03-03 Isoxazole compounds for the treatment of cancer ZA201001546B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07118421 2007-10-12

Publications (1)

Publication Number Publication Date
ZA201001546B true ZA201001546B (en) 2010-10-27

Family

ID=38952098

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA201001546A ZA201001546B (en) 2007-10-12 2010-03-03 Isoxazole compounds for the treatment of cancer

Country Status (19)

Country Link
US (6) US20100210650A1 (ko)
EP (3) EP3427797A1 (ko)
JP (2) JP5800504B2 (ko)
KR (4) KR101841872B1 (ko)
CN (2) CN104306377A (ko)
AU (1) AU2008309562B2 (ko)
BR (1) BRPI0818559A2 (ko)
CA (1) CA2700795C (ko)
CL (1) CL2008003005A1 (ko)
ES (1) ES2500920T3 (ko)
MA (1) MA31765B1 (ko)
MX (1) MX2010003988A (ko)
PL (1) PL2263751T3 (ko)
PT (1) PT2263751E (ko)
RU (1) RU2491938C2 (ko)
TN (1) TN2010000139A1 (ko)
TW (1) TW200922595A (ko)
WO (1) WO2009047323A2 (ko)
ZA (1) ZA201001546B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140078656A (ko) * 2011-10-14 2014-06-25 노파르티스 아게 증식성 질환의 치료를 위한 hsp90 억제제와 조합된 2-카르복스아미드 시클로아미노 우레아 유도체
CA2902699A1 (en) * 2013-03-15 2014-09-18 Novartis Ag Biomarker
CA2992629C (en) * 2015-08-24 2020-06-30 Shanxi Yabao Health Products Co., Ltd. Use of dihydroxyacetone in preparation of anti-cancer medicaments
KR102653960B1 (ko) * 2020-07-23 2024-04-03 의료법인 성광의료재단 암 치료를 위한 면역체크포인트 억제제의 병용 요법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003282512A1 (en) * 2002-10-22 2004-05-13 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Methods of reducing the activity of and reducing the concentration of a mutant kit protein
PT1611112E (pt) * 2003-02-11 2012-11-02 Cancer Rec Tech Ltd Compostos de isoxazole como inibidores de proteínas de choque térmico
US20050054625A1 (en) * 2003-05-30 2005-03-10 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with nuclear export inhibitors
JP2008536867A (ja) * 2005-04-14 2008-09-11 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド 増殖疾患を処置する際に有用なｈｓｐ９０インヒビターとしての２−アミノ−キナゾリン−５−オン
US20070105862A1 (en) * 2005-11-10 2007-05-10 Milan Bruncko Heat-shock protein binders
KR20090122218A (ko) * 2007-03-01 2009-11-26 노파르티스 아게 ５-(２,４-디히드록시-５-이소프로필-페닐)-４-(４-모르폴린-４-일메틸-페닐)-이속사졸-３-카르복실산 에틸아미드의 산 부가염, 수화물 및 다형체, 및 이들 형태를 포함하는 제제

Also Published As

Publication number Publication date
PL2263751T3 (pl) 2014-12-31
JP2014156475A (ja) 2014-08-28
RU2010118458A (ru) 2011-11-20
AU2008309562A1 (en) 2009-04-16
KR20160143877A (ko) 2016-12-14
WO2009047323A3 (en) 2009-11-12
RU2491938C2 (ru) 2013-09-10
EP2263751B1 (en) 2014-07-09
KR20170124642A (ko) 2017-11-10
PT2263751E (pt) 2014-09-10
MX2010003988A (es) 2010-04-27
US20100210650A1 (en) 2010-08-19
WO2009047323A2 (en) 2009-04-16
JP2011500535A (ja) 2011-01-06
US20160045513A1 (en) 2016-02-18
EP2209529A2 (en) 2010-07-28
US20140288075A1 (en) 2014-09-25
EP3427797A1 (en) 2019-01-16
US20120083496A1 (en) 2012-04-05
KR20160040738A (ko) 2016-04-14
TW200922595A (en) 2009-06-01
KR20100075902A (ko) 2010-07-05
JP5800504B2 (ja) 2015-10-28
US20120214813A1 (en) 2012-08-23
TN2010000139A1 (en) 2011-09-26
EP2209529B1 (en) 2018-09-19
US20160220576A1 (en) 2016-08-04
CN104306377A (zh) 2015-01-28
CL2008003005A1 (es) 2009-05-08
MA31765B1 (fr) 2010-10-01
ES2500920T3 (es) 2014-10-01
BRPI0818559A2 (pt) 2015-04-22
KR101841872B1 (ko) 2018-03-26
CA2700795C (en) 2017-03-07
CN101795728A (zh) 2010-08-04
EP2263751A1 (en) 2010-12-22
AU2008309562B2 (en) 2012-01-19
CA2700795A1 (en) 2009-04-16

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