ZA200908649B - Rage fusion proteins - Google Patents
Rage fusion proteinsInfo
- Publication number
- ZA200908649B ZA200908649B ZA200908649A ZA200908649A ZA200908649B ZA 200908649 B ZA200908649 B ZA 200908649B ZA 200908649 A ZA200908649 A ZA 200908649A ZA 200908649 A ZA200908649 A ZA 200908649A ZA 200908649 B ZA200908649 B ZA 200908649B
- Authority
- ZA
- South Africa
- Prior art keywords
- fusion proteins
- rage fusion
- rage
- proteins
- fusion
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94399407P | 2007-06-14 | 2007-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200908649B true ZA200908649B (en) | 2010-08-25 |
Family
ID=40156919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200908649A ZA200908649B (en) | 2007-06-14 | 2009-12-07 | Rage fusion proteins |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8398977B2 (enExample) |
| EP (1) | EP2158210B1 (enExample) |
| JP (2) | JP5706688B2 (enExample) |
| KR (2) | KR101595634B1 (enExample) |
| CN (1) | CN101842382A (enExample) |
| AU (1) | AU2008265983B2 (enExample) |
| BR (1) | BRPI0813452A2 (enExample) |
| CA (1) | CA2690056C (enExample) |
| CO (1) | CO6241158A2 (enExample) |
| EC (1) | ECSP099804A (enExample) |
| ES (1) | ES2564634T3 (enExample) |
| IL (1) | IL202443B (enExample) |
| MX (1) | MX2009013194A (enExample) |
| NZ (1) | NZ581550A (enExample) |
| PL (1) | PL2158210T3 (enExample) |
| RU (1) | RU2513695C2 (enExample) |
| WO (1) | WO2008157378A2 (enExample) |
| ZA (1) | ZA200908649B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ552128A (en) | 2004-08-03 | 2009-09-25 | Transtech Pharma Inc | Rage fusion proteins without Fc hinge region and methods of use |
| WO2008151088A2 (en) | 2007-06-01 | 2008-12-11 | University Of Maryland, Baltimore | Immunoglobulin constant region fc receptor binding agents |
| CN104987416A (zh) | 2008-05-23 | 2015-10-21 | Siwa有限公司 | 促进再生的方法、组合物及设备 |
| US9034341B2 (en) | 2009-04-20 | 2015-05-19 | Transtech Pharma, Llc | Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions |
| WO2011102845A1 (en) * | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Rage fusion protein compositions and methods of use |
| EP2598533B1 (en) | 2010-07-28 | 2019-02-20 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
| US9649376B2 (en) | 2010-09-27 | 2017-05-16 | Siwa Corporation | Selective removal of age-modified cells for treatment of atherosclerosis |
| US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
| EP2807194A4 (en) * | 2012-01-27 | 2015-12-02 | Gliknik Inc | FUSION PROTEINS WITH IGG2 HINGEOMS |
| BR112015032763A2 (pt) | 2013-07-05 | 2017-11-07 | H Lee Moffitt Cancer Ct & Res | cd33 solúvel para tratar síndromes mielodisplásicas (mds) |
| RU2721568C2 (ru) | 2014-09-19 | 2020-05-20 | Сива Корпорейшн | Анти-age антитела для лечения воспаления и аутоиммунных нарушений |
| JP6679096B2 (ja) * | 2014-10-21 | 2020-04-15 | 学校法人 久留米大学 | Rageアプタマーおよびその用途 |
| US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
| US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
| AU2016297862C1 (en) | 2015-07-24 | 2022-12-15 | Gliknik Inc. | Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin Fc compositions with enhanced complement binding |
| AU2017219749B2 (en) | 2016-02-19 | 2022-01-06 | Siwa Corporation | Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (AGE) |
| WO2017181116A1 (en) | 2016-04-15 | 2017-10-19 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
| US11034775B2 (en) | 2016-06-07 | 2021-06-15 | Gliknik Inc. | Cysteine-optimized stradomers |
| JP2019518763A (ja) | 2016-06-23 | 2019-07-04 | シワ コーポレーション | 様々な疾患及び障害の治療において使用するためのワクチン |
| KR20190093186A (ko) | 2016-12-09 | 2019-08-08 | 글리크닉 인코포레이티드 | 다가 Fc 화합물에 의해 염증성 장애를 치료하는 방법 |
| PE20191354A1 (es) | 2016-12-09 | 2019-10-01 | Gliknik Inc | Optimizacion de fabricacion de gl-2045, un stradomer multimerizante |
| US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
| US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
| US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
| US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
| JP6964322B2 (ja) * | 2017-03-13 | 2021-11-10 | 学校法人 久留米大学 | ループス腎炎を処置または予防するための医薬組成物およびループス腎炎のバイオマーカー |
| US10919957B2 (en) | 2017-04-13 | 2021-02-16 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
| US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
| WO2020056379A1 (en) | 2018-09-14 | 2020-03-19 | BioAge Labs, Inc. | Rage fusion proteins with improved stability and ligand binding affinity and uses thereof |
| US11684653B2 (en) * | 2019-03-06 | 2023-06-27 | The Cleveland Clinic Foundation | Compositions and method for reducing virulence of microorganisms |
| CN118043351A (zh) * | 2021-08-31 | 2024-05-14 | 上海医药集团股份有限公司 | 靶向Siglec15的抗原结合蛋白及其用途 |
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| US6555651B2 (en) | 1997-10-09 | 2003-04-29 | The Trustees Of Columbia University In The City Of New York | Ligand binding site of rage and uses thereof |
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| US6753150B2 (en) | 1998-10-05 | 2004-06-22 | The Trustees Of Columbia University In The City Of New York | Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage |
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| US6589944B1 (en) | 1999-04-05 | 2003-07-08 | City Of Hope | Breakers of advanced glycation endproducts |
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| FR2797402B1 (fr) | 1999-07-15 | 2004-03-12 | Biomerieux Stelhys | Utilisation d'un polypeptide pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique ou autoimmune |
| CA2382095A1 (en) | 1999-08-13 | 2001-02-22 | The Trustees Of Columbia University In The City Of New York | Methods of inhibiting binding of .beta.-sheet fibril to rage and consequences thereof |
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-
2008
- 2008-06-13 MX MX2009013194A patent/MX2009013194A/es active IP Right Grant
- 2008-06-13 AU AU2008265983A patent/AU2008265983B2/en active Active
- 2008-06-13 CN CN200880102246A patent/CN101842382A/zh active Pending
- 2008-06-13 US US12/664,111 patent/US8398977B2/en active Active
- 2008-06-13 WO PCT/US2008/066956 patent/WO2008157378A2/en not_active Ceased
- 2008-06-13 KR KR1020137011740A patent/KR101595634B1/ko active Active
- 2008-06-13 EP EP08771049.7A patent/EP2158210B1/en active Active
- 2008-06-13 KR KR1020107000753A patent/KR101361355B1/ko active Active
- 2008-06-13 BR BRPI0813452A patent/BRPI0813452A2/pt not_active Application Discontinuation
- 2008-06-13 JP JP2010512391A patent/JP5706688B2/ja active Active
- 2008-06-13 RU RU2010100913/10A patent/RU2513695C2/ru active
- 2008-06-13 NZ NZ581550A patent/NZ581550A/en unknown
- 2008-06-13 PL PL08771049T patent/PL2158210T3/pl unknown
- 2008-06-13 ES ES08771049.7T patent/ES2564634T3/es active Active
- 2008-06-13 CA CA2690056A patent/CA2690056C/en active Active
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2009
- 2009-12-01 IL IL202443A patent/IL202443B/en active IP Right Grant
- 2009-12-07 ZA ZA200908649A patent/ZA200908649B/xx unknown
- 2009-12-11 CO CO09142110A patent/CO6241158A2/es active IP Right Grant
- 2009-12-14 EC EC2009009804A patent/ECSP099804A/es unknown
-
2013
- 2013-02-14 US US13/767,081 patent/US9066927B2/en active Active
-
2015
- 2015-02-27 JP JP2015038891A patent/JP5887441B2/ja active Active
- 2015-05-22 US US14/720,107 patent/US9399668B2/en active Active
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