ZA200907191B - Process for the preparation of gefitiib - Google Patents

Process for the preparation of gefitiib

Info

Publication number
ZA200907191B
ZA200907191B ZA200907191A ZA200907191A ZA200907191B ZA 200907191 B ZA200907191 B ZA 200907191B ZA 200907191 A ZA200907191 A ZA 200907191A ZA 200907191 A ZA200907191 A ZA 200907191A ZA 200907191 B ZA200907191 B ZA 200907191B
Authority
ZA
South Africa
Prior art keywords
gefitiib
preparation
Prior art date
Application number
ZA200907191A
Other languages
English (en)
Inventor
Dharmaraj Ramachandra Rao
Rajendra Narayanrao Kankan
Srinivas Laxminarayan Pathi
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of ZA200907191B publication Critical patent/ZA200907191B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/285—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with peroxy-compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA200907191A 2007-04-16 2009-10-15 Process for the preparation of gefitiib ZA200907191B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN745MU2007 2007-04-16

Publications (1)

Publication Number Publication Date
ZA200907191B true ZA200907191B (en) 2010-06-30

Family

ID=39537889

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200907191A ZA200907191B (en) 2007-04-16 2009-10-15 Process for the preparation of gefitiib

Country Status (9)

Country Link
US (1) US8350029B2 (enExample)
EP (1) EP2155656A2 (enExample)
JP (1) JP2010524909A (enExample)
KR (1) KR20100017101A (enExample)
AU (1) AU2008237749B2 (enExample)
CA (1) CA2683694A1 (enExample)
NZ (1) NZ580382A (enExample)
WO (1) WO2008125867A2 (enExample)
ZA (1) ZA200907191B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008125867A2 (en) 2007-04-16 2008-10-23 Cipla Limited Process for the preparation of gefitinib
CN102557977B (zh) * 2010-12-20 2014-07-30 浙江海正药业股份有限公司 埃罗替尼的合成中间体及其制备方法
CN102911125B (zh) * 2011-08-05 2016-03-02 浙江九洲药业股份有限公司 一种吉非替尼中间体的制备方法
KR101457453B1 (ko) * 2012-05-31 2014-11-04 주식회사 종근당 게피티닙의 제조방법 및 이의 제조에 사용되는 중간체
WO2014147631A1 (en) 2013-03-22 2014-09-25 Natco Pharma Limited Formulation comprising gefitinib as oral suspension
CN103304491A (zh) * 2013-06-17 2013-09-18 连云港盛和生物科技有限公司 一种吉非替尼的制备方法
CN103864702B (zh) * 2014-02-27 2016-05-11 福建医科大学 一种在水相中微波催化制备喹唑酮化合物的方法
CN104016929B (zh) * 2014-06-25 2016-03-30 北京理工大学 一种合成喹唑啉-4(3h)-酮的方法
CN105503748A (zh) * 2015-12-31 2016-04-20 哈药集团技术中心 一种吉非替尼的制备方法
CN107915643A (zh) * 2016-10-09 2018-04-17 浙江瑞博制药有限公司 一种5‑(3‑羟基丙氧基)‑4‑甲氧基‑2‑硝基甲酯苯甲酸的制备方法
CN110776471A (zh) * 2019-11-28 2020-02-11 王爱平 一种抑制肿瘤细胞药物的合成方法
CN114957200B (zh) * 2022-05-31 2024-07-26 湖南华腾制药有限公司 抗癌药物埃克替尼关键中间体的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
PT885198E (pt) * 1996-03-05 2002-06-28 Astrazeneca Ab Derivados de 4-anilinoquinazolina
IT1296985B1 (it) 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
CZ20021009A3 (cs) * 1999-09-21 2002-06-12 Astrazeneca Ab Deriváty chinazolinu, způsob jejich přípravy a jejich pouľití jako léčiv
US8367824B2 (en) * 2002-01-28 2013-02-05 Ube Industries Ltd. Process for producing quinazolin-4-one derivative
GB0221245D0 (en) * 2002-09-13 2002-10-23 Astrazeneca Ab Chemical process
GB0320793D0 (en) 2003-09-05 2003-10-08 Astrazeneca Ab Chemical process
WO2005070909A1 (en) * 2004-01-22 2005-08-04 Natco Pharma Limited An improved process for the preparation of gefitinib
WO2008125867A2 (en) 2007-04-16 2008-10-23 Cipla Limited Process for the preparation of gefitinib

Also Published As

Publication number Publication date
KR20100017101A (ko) 2010-02-16
WO2008125867A2 (en) 2008-10-23
US8350029B2 (en) 2013-01-08
CA2683694A1 (en) 2008-10-23
EP2155656A2 (en) 2010-02-24
AU2008237749B2 (en) 2013-01-17
JP2010524909A (ja) 2010-07-22
US20100137586A1 (en) 2010-06-03
NZ580382A (en) 2012-05-25
WO2008125867A3 (en) 2008-12-24
AU2008237749A1 (en) 2008-10-23

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