ZA200906620B - Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized LDL receptor-1 (LOX-1) - Google Patents

Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized LDL receptor-1 (LOX-1)

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Publication number
ZA200906620B
ZA200906620B ZA200906620A ZA200906620A ZA200906620B ZA 200906620 B ZA200906620 B ZA 200906620B ZA 200906620 A ZA200906620 A ZA 200906620A ZA 200906620 A ZA200906620 A ZA 200906620A ZA 200906620 B ZA200906620 B ZA 200906620B
Authority
ZA
South Africa
Prior art keywords
lox
activation
presenting cells
dendritic cell
ldl receptor
Prior art date
Application number
ZA200906620A
Other languages
English (en)
Inventor
Jacques F Banchereau
Sangkon Oh
Gerard Zurawski
Sandra Zurawski
Dapeng Li
Original Assignee
Baylor Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor Res Inst filed Critical Baylor Res Inst
Publication of ZA200906620B publication Critical patent/ZA200906620B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Epidemiology (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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ZA200906620A 2007-02-23 2009-09-22 Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized LDL receptor-1 (LOX-1) ZA200906620B (en)

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US89142407P 2007-02-23 2007-02-23

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Country Link
US (2) US8481314B2 (https=)
EP (2) EP2132226B1 (https=)
JP (3) JP2010518834A (https=)
KR (1) KR20090127886A (https=)
CN (1) CN101668772A (https=)
AU (1) AU2008218190C1 (https=)
BR (1) BRPI0807563A2 (https=)
CA (1) CA2715919C (https=)
IL (1) IL200529A0 (https=)
MX (1) MX2009008919A (https=)
NZ (2) NZ579257A (https=)
TW (2) TWI440468B (https=)
WO (1) WO2008103953A2 (https=)
ZA (1) ZA200906620B (https=)

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EP3554544A4 (en) 2016-12-16 2020-07-29 Bluefin Biomedicine, Inc. ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
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CA3066918A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
AR124681A1 (es) 2021-01-20 2023-04-26 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
CN114657121B (zh) * 2022-03-23 2023-07-25 新乡医学院 LOX1基因作为流体剪切力作用下BMSCs成骨分化促进剂的应用
WO2025027529A1 (en) 2023-07-31 2025-02-06 Advesya Anti-il-1rap antibody drug conjugates and methods of use thereof
CN119119263B (zh) * 2023-10-08 2025-02-14 安徽千诚生物技术有限公司 一种pct蛋白抗体、定量检测pct蛋白的胶乳增强免疫比浊试剂盒及其制备
TW202530255A (zh) 2023-12-15 2025-08-01 法商亞維西亞有限公司 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物

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CA2715919C (en) 2020-04-21
JP2010518834A (ja) 2010-06-03
AU2008218190B2 (en) 2012-11-01
EP2132226A2 (en) 2009-12-16
US9339556B2 (en) 2016-05-17
IL200529A0 (en) 2010-04-29
KR20090127886A (ko) 2009-12-14
TWI556826B (zh) 2016-11-11
WO2008103953A3 (en) 2008-10-16
EP3489260B1 (en) 2020-12-02
CN101668772A (zh) 2010-03-10
TWI440468B (zh) 2014-06-11
US20080267984A1 (en) 2008-10-30
EP2132226B1 (en) 2019-03-27
BRPI0807563A2 (pt) 2014-07-01
TW201141520A (en) 2011-12-01
US20140120617A1 (en) 2014-05-01
JP6422797B2 (ja) 2018-11-14
AU2008218190C1 (en) 2013-05-02
JP2015157809A (ja) 2015-09-03
JP2017149718A (ja) 2017-08-31
NZ579257A (en) 2011-05-27
EP2132226A4 (en) 2012-12-26
AU2008218190A1 (en) 2008-08-28
TW200848075A (en) 2008-12-16
WO2008103953A2 (en) 2008-08-28
US8481314B2 (en) 2013-07-09
NZ589341A (en) 2012-02-24
EP3489260A1 (en) 2019-05-29
CA2715919A1 (en) 2008-08-28
MX2009008919A (es) 2010-01-25

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