ZA200904470B - Gelatin-transglutaminase hemostatic dressings and sealants - Google Patents

Gelatin-transglutaminase hemostatic dressings and sealants

Info

Publication number
ZA200904470B
ZA200904470B ZA200904470A ZA200904470A ZA200904470B ZA 200904470 B ZA200904470 B ZA 200904470B ZA 200904470 A ZA200904470 A ZA 200904470A ZA 200904470 A ZA200904470 A ZA 200904470A ZA 200904470 B ZA200904470 B ZA 200904470B
Authority
ZA
South Africa
Prior art keywords
sealants
gelatin
hemostatic dressings
transglutaminase
transglutaminase hemostatic
Prior art date
Application number
ZA200904470A
Other languages
English (en)
Inventor
Orahn Preiss-Bloom
Ishay Attar
Natalie Iram
Original Assignee
Lifebond Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39733194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200904470(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lifebond Ltd filed Critical Lifebond Ltd
Publication of ZA200904470B publication Critical patent/ZA200904470B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/104—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0038—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200904470A 2006-12-15 2009-06-26 Gelatin-transglutaminase hemostatic dressings and sealants ZA200904470B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87515006P 2006-12-15 2006-12-15

Publications (1)

Publication Number Publication Date
ZA200904470B true ZA200904470B (en) 2010-04-28

Family

ID=39733194

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200904470A ZA200904470B (en) 2006-12-15 2009-06-26 Gelatin-transglutaminase hemostatic dressings and sealants

Country Status (5)

Country Link
US (1) US8133484B2 (de)
EP (2) EP2586467B1 (de)
CN (1) CN105079871A (de)
CA (1) CA2836067C (de)
ZA (1) ZA200904470B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9017664B2 (en) * 2006-12-15 2015-04-28 Lifebond Ltd. Gelatin-transglutaminase hemostatic dressings and sealants
CN104031393B (zh) 2008-06-18 2017-08-01 生命连结有限公司 改进的交联组合物
US20100318120A1 (en) * 2009-06-15 2010-12-16 John Howard Gordon Hemostatic material and delivery device
US9066991B2 (en) * 2009-12-22 2015-06-30 Lifebond Ltd. Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
CA2807012A1 (en) 2010-08-05 2012-02-09 Lifebond Ltd. Dry composition wound dressings and adhesives
US20120143228A1 (en) 2010-08-30 2012-06-07 Agency For Science Technology And Research Adhesive structure with stiff protrusions on adhesive surface
US9492952B2 (en) 2010-08-30 2016-11-15 Endo-Surgery, Inc. Super-hydrophilic structures
US9447169B2 (en) 2011-03-04 2016-09-20 Orthovita, Inc. Flowable collagen-based hemostat and methods of use
US10278701B2 (en) 2011-12-29 2019-05-07 Ethicon, Inc. Adhesive structure with tissue piercing protrusions on its surface
US8969648B2 (en) 2012-04-06 2015-03-03 Ethicon, Inc. Blood clotting substrate and medical device
US8926881B2 (en) 2012-04-06 2015-01-06 DePuy Synthes Products, LLC Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them
JPWO2014112208A1 (ja) * 2013-01-18 2017-01-19 国立研究開発法人物質・材料研究機構 組織接着剤及びその製造方法
US9446166B2 (en) 2013-01-24 2016-09-20 Ethicon, Inc. Fibrin sealant compositions with chemical crosslinking
WO2015145457A1 (en) 2014-03-24 2015-10-01 Datt Mediproducts Limited A ready to use biodegradable and biocompatible device and a method of preparation thereof
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CN105288638B (zh) * 2015-10-27 2018-07-06 江苏金维氨生物工程有限公司 一种提高支链氨基酸粉剂堆积密度的方法
EP3600462B1 (de) * 2017-03-31 2022-09-21 Medcura, Inc. Hydrophob modifizierte polymerschaumstoffe und verfahren zur verwendung
CN111051507A (zh) * 2017-09-07 2020-04-21 天野酶制品株式会社 稳定化蛋白质脱酰胺酶干燥组合物
EP3691699A4 (de) * 2017-10-04 2021-06-30 Bio-Change Ltd. Vernetzte proteinschäume und verfahren zur verwendung davon in einem polyvalenten zellengerüst
CN108478849B (zh) * 2018-02-07 2021-04-16 广州迈普再生医学科技股份有限公司 一种可吸收可黏附止血海绵及其制备方法
CN111068102B (zh) * 2019-12-18 2022-04-12 陕西科技大学 酶促凝血抗菌可控的明胶基水凝胶及其制备方法
CN114939185B (zh) * 2022-05-19 2023-03-24 北京化工大学 一种阳离子化多糖多酚复合止血涂层的制备方法
CN115737905B (zh) * 2022-11-01 2023-12-08 重庆工商大学 一种负载纳米二氧化硅的人工骨膜及其制备方法和应用

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA896965A (en) 1972-04-04 De Boer Rintje Process for producing a dry gelatin product
US2166074A (en) 1937-04-09 1939-07-11 Sharp & Dohme Inc Gelatinous colloids
US2398004A (en) 1943-07-20 1946-04-09 Eastman Kodak Co Controlling the isoelectric point of gelatin
US2558065A (en) 1949-05-03 1951-06-26 Linwood F Tice Method of preparing solutions of gelatin in polyhydric alcohols
US2803548A (en) 1955-02-07 1957-08-20 Louis Milani Foods Inc Method of making gelatin-containing food preparations which dissolve at room temperature and gel at room temperature
US3939001A (en) 1973-06-08 1976-02-17 General Foods Corporation Spoonable frozen gelatin dessert concentrate
JPS5832576B2 (ja) 1976-10-28 1983-07-14 協和醗酵工業株式会社 ゼラチンの改質法
CA1202904A (en) * 1983-11-21 1986-04-08 Brian G. Sparkes Chitosan based wound dressing materials
US4711848A (en) 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
DE3682047D1 (de) 1985-07-09 1991-11-21 Quadrant Bioresources Ltd Beschuetzung von proteinen und aehnlichem.
FR2586030B1 (fr) 1985-08-07 1987-12-18 Rousselot Cie Gelatine a proprietes ameliorees et son procede de preparation par pelliculage avec une gelatine hydrolysee
DE3726963A1 (de) 1987-08-13 1989-02-23 Stoess & Co Gelatine Kaltwasserloesliche, instantisierte gelatine und verfahren zur herstellung derselben
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
JP3550685B2 (ja) * 1992-04-21 2004-08-04 味の素株式会社 創傷治療剤
US5549904A (en) * 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
US5939385A (en) 1993-08-13 1999-08-17 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
US5428014A (en) 1993-08-13 1995-06-27 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
ES2218553T3 (es) 1994-10-11 2004-11-16 Ajinomoto Co., Inc. Transglutaminasa estabilizada y preparacion enzimatica que la contiene.
FR2726571B1 (fr) * 1994-11-03 1997-08-08 Izoret Georges Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique
US7253262B2 (en) 1995-01-19 2007-08-07 Quandrant Drug Delivery Limited Dried blood factor composition comprising trehalose
GB9501040D0 (en) 1995-01-19 1995-03-08 Quadrant Holdings Cambridge Dried composition
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
DE19604706A1 (de) * 1996-02-09 1997-08-14 Merck Patent Gmbh Vernetzungsprodukte von Aminogruppen-haltigen Biopolymeren
US5834232A (en) * 1996-05-01 1998-11-10 Zymogenetics, Inc. Cross-linked gelatin gels and methods of making them
EP0914168A1 (de) * 1996-05-03 1999-05-12 Innogenetics N.V. Neue medikamente aus gelatine die mit einem oxidierten polysaccarid vernetzt ist
US7320962B2 (en) 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US7435425B2 (en) 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US6015474A (en) 1997-06-20 2000-01-18 Protein Polymer Technologies Methods of using primer molecules for enhancing the mechanical performance of tissue adhesives and sealants
US6190896B1 (en) 1997-11-14 2001-02-20 Bassam M. Fraij Active human cellular transglutaminase
US6762336B1 (en) * 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
US6428978B1 (en) * 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
US7241730B2 (en) 1998-08-27 2007-07-10 Universitat Zurich Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides
US6992172B1 (en) * 1999-11-12 2006-01-31 Fibrogen, Inc. Recombinant gelatins
US6682760B2 (en) 2000-04-18 2004-01-27 Colbar R&D Ltd. Cross-linked collagen matrices and methods for their preparation
AU2002307814B2 (en) 2001-05-16 2006-12-07 Susanna Elizabeth Chalmers Wound dressings and wound treatment compositions
US8741335B2 (en) 2002-06-14 2014-06-03 Hemcon Medical Technologies, Inc. Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan
AU2002346648A1 (en) * 2001-12-04 2003-06-17 Christopher J Woolverton Storage-stable fibrin sealant
US8501165B2 (en) 2001-12-12 2013-08-06 Promethean Surgical Devices Llc In situ bonds
US20070082023A1 (en) 2002-06-14 2007-04-12 Hemcon Medical Technologies, Inc. Supple tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan
AU2003270401B2 (en) * 2002-09-10 2008-03-13 American National Red Cross Hemostatic dressing
ES2441414T3 (es) 2002-09-26 2014-02-04 Ajinomoto Co., Inc. Preparación enzimática y procedimiento para producir alimentos que utiliza la misma
US20060258560A1 (en) 2002-09-30 2006-11-16 Chunlin Yang Dry tissue sealant compositions
GB2393656B (en) 2002-10-01 2005-11-16 Johnson & Johnson Medical Ltd Enzyme-sensitive therapeutic wound dressings
EP1562630A4 (de) 2002-10-31 2009-02-18 Univ Northwestern INJIZIERBARE BIOADHûSIVE POLYMERE HYDROGELEUND RELEVANTE VERFAHREN ZUR ENZYMATISCHEN HERSTELLUNG
US6863783B2 (en) 2002-11-14 2005-03-08 The Meow Mix Company Method of producing electrostatically charged gelatin
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
US7186684B2 (en) 2003-08-07 2007-03-06 Ethicon, Inc. Hemostatic device containing a protein precipitate
WO2005055958A2 (en) 2003-12-09 2005-06-23 Promethean Surgical Devices Llc Improved surgical adhesive and uses therefor
US7109163B2 (en) 2004-01-30 2006-09-19 Ethicon, Inc. Hemostatic compositions and devices
WO2005120462A2 (en) 2004-06-07 2005-12-22 Callisyn Pharmaceuticals, Inc. Biodegradable and biocompatible crosslinked polymer hydrogel prepared from pva and/or peg macromer mixtures
US20050281800A1 (en) 2004-06-16 2005-12-22 Glen Gong Targeting sites of damaged lung tissue
US20060100138A1 (en) 2004-11-10 2006-05-11 Olsen David R Implantable collagen compositions
WO2007067623A2 (en) 2005-12-06 2007-06-14 Tyco Healthcare Group Lp Biocompatible tissue sealants and adhesives
CA2573472A1 (en) 2006-01-23 2007-07-23 Tyco Healthcare Group Lp Biodegradable hemostatic compositions
KR20070104748A (ko) * 2006-04-24 2007-10-29 박현진 어류 젤라틴 하드 캅셀용 필름 형성 조성물 및 이의제조방법
DE102006033167A1 (de) 2006-07-10 2008-01-24 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
US9910952B2 (en) 2016-06-30 2018-03-06 International Business Machines Corporation Hierarchically aware interior pinning for large synthesis blocks

Also Published As

Publication number Publication date
EP2586467A3 (de) 2013-07-17
EP2586467B1 (de) 2018-05-02
EP2586467A2 (de) 2013-05-01
US8133484B2 (en) 2012-03-13
CN105079871A (zh) 2015-11-25
EP2455109A2 (de) 2012-05-23
EP2455109B1 (de) 2015-02-11
CA2836067A1 (en) 2008-06-26
CA2836067C (en) 2016-02-09
EP2455109B2 (de) 2021-11-03
EP2455109A3 (de) 2012-06-13
US20080213243A1 (en) 2008-09-04

Similar Documents

Publication Publication Date Title
ZA200904470B (en) Gelatin-transglutaminase hemostatic dressings and sealants
HK1148488A1 (en) Gelatin transglutaminase hemostatic dressings and sealants
EP2219572A4 (de) Resorbierbare nanoverstärkte hämostatische strukturen und verbandsmaterialien
EP1973534A4 (de) Hämostatischer textilstoff
EP2076275A4 (de) Verfahren und zusammensetzungen zur abheilung diabetischer wunden
ZA200806607B (en) Hemostatic material
EP2207508A4 (de) Ein adsorbens enthaltende hämostatische vorrichtungen
EP2015722A4 (de) Antimikrobielle verbände
ZA200806606B (en) Hemostatic material
EP2012839A4 (de) Neue antimikrobielle substrate und ihre verwendungen
EP3000487B8 (de) Blutstillende zusammensetzungen und therapieansätze
EP2039705A4 (de) Modifizierter dienkautschuk und diesen enthaltende kautschukzusammensetzung
GB0608437D0 (en) Wound dressings
EP2064300A4 (de) Gewebehaftzusammensetzungen und verfahren dafür
EP1991256A4 (de) Gerinnungs- und heilungszusammensetzungen mit keratinbiomaterial
TWI371444B (en) Compound and polymer compound
HK1165444A1 (zh) 用於調整止血的組合物及方法
EP1993588A4 (de) Gewebeklebstoffe und -versiegelungsmittel und verfahren zu deren verwendung
PL2178963T3 (pl) Sieciujący się silanem klej lub materiał uszczelniający z n-sililoalkiloamidami i jego zastosowanie
EP2042152A4 (de) Gelzusammensetzung
EP2006352A4 (de) Flüssigkristalline zusammensetzung und flüssigkristallines element
TWM298784U (en) Attenuator
PL2099862T3 (pl) Nowa kompozycja termoplastyczna i jej zastosowanie
GB0619375D0 (en) Wound healing compositions
PT2129298E (pt) Aplicação de hemostático