ZA200902640B - Purines as PKC-Theta inhibitors - Google Patents

Purines as PKC-Theta inhibitors

Info

Publication number
ZA200902640B
ZA200902640B ZA200902640A ZA200902640A ZA200902640B ZA 200902640 B ZA200902640 B ZA 200902640B ZA 200902640 A ZA200902640 A ZA 200902640A ZA 200902640 A ZA200902640 A ZA 200902640A ZA 200902640 B ZA200902640 B ZA 200902640B
Authority
ZA
South Africa
Prior art keywords
pkc
purines
theta inhibitors
theta
inhibitors
Prior art date
Application number
ZA200902640A
Other languages
English (en)
Inventor
Irina Neagu
Andrew Roughton
Koc-Kan Ho
David Diller
Jui Hsiang Chan
Celia Kingsbury
Michael Ohlmeyer
Jacobus Cornells Henricus Maria Wijkmans
Neeltje Miranda Teerhuis
Johannes Petrus Maria Lommerse
Original Assignee
Nv Organon Pharmacopeia Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nv Organon Pharmacopeia Llc filed Critical Nv Organon Pharmacopeia Llc
Publication of ZA200902640B publication Critical patent/ZA200902640B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200902640A 2006-10-20 2009-04-16 Purines as PKC-Theta inhibitors ZA200902640B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85339606P 2006-10-20 2006-10-20

Publications (1)

Publication Number Publication Date
ZA200902640B true ZA200902640B (en) 2010-05-26

Family

ID=39111415

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200902640A ZA200902640B (en) 2006-10-20 2009-04-16 Purines as PKC-Theta inhibitors

Country Status (17)

Country Link
US (1) US20110046131A1 (ko)
EP (1) EP2078019A2 (ko)
JP (1) JP2010507581A (ko)
KR (1) KR20090075854A (ko)
CN (1) CN101657453B (ko)
AU (1) AU2007309167A1 (ko)
BR (1) BRPI0717435A2 (ko)
CA (1) CA2666940A1 (ko)
CO (1) CO6160294A2 (ko)
EC (1) ECSP099342A (ko)
IL (1) IL198080A0 (ko)
IN (1) IN2009CN02154A (ko)
MX (1) MX2009004154A (ko)
NO (1) NO20091597L (ko)
RU (1) RU2009118963A (ko)
WO (1) WO2008051826A2 (ko)
ZA (1) ZA200902640B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090281075A1 (en) * 2006-02-17 2009-11-12 Pharmacopeia, Inc. Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors
US7989459B2 (en) * 2006-02-17 2011-08-02 Pharmacopeia, Llc Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
EP1991547A2 (en) * 2006-03-09 2008-11-19 Pharmacopeia, Inc. 8-heteroarylpurine mnk2 inhibitors for treating metabolic disorders
EP2038274A2 (en) * 2006-06-23 2009-03-25 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
WO2011066211A1 (en) * 2009-11-24 2011-06-03 Glaxosmithkline Llc Azabenzimidazoles as fatty acid synthase inhibitors
MX2012008643A (es) * 2010-01-27 2013-02-26 Vertex Pharma Inhibidores de cinasas de pirazolopiridinas.
CN103209695A (zh) 2010-09-15 2013-07-17 弗·哈夫曼-拉罗切有限公司 氮杂苯并噻唑化合物、组合物及应用方法
CA2845409A1 (en) * 2011-09-20 2013-03-28 Yingjie Lai Imidazopyridine compounds, compositions and methods of use
US10485772B2 (en) 2014-08-25 2019-11-26 EpiAxis Therapeutics Pty Ltd. Compositions for modulating cancer stem cells and uses therefor
JP7161760B2 (ja) * 2017-02-03 2022-10-27 国立大学法人東北大学 複素環化合物
WO2019090390A1 (en) * 2017-11-08 2019-05-16 University Of Canberra Immunogenic compositions and uses therefor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
KR100540046B1 (ko) * 1997-11-12 2006-01-10 미쓰비시 가가꾸 가부시키가이샤 퓨린유도체 및 이를 유효성분으로 함유하는 의약
WO2003097062A1 (en) * 2002-05-13 2003-11-27 Merck & Co., Inc. Phenyl substituted imidazopyridines and phenyl substituted benzimidazoles
JP2004217582A (ja) * 2003-01-16 2004-08-05 Abbott Japan Co Ltd ９ｈ−プリン誘導体
CN101048410B (zh) * 2004-10-29 2010-06-23 泰博特克药品有限公司 抑制hiv的双环嘧啶衍生物
US7723340B2 (en) * 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
DK1853588T3 (da) * 2005-02-16 2008-09-15 Astrazeneca Ab Kemiske forbindelser
WO2006091737A1 (en) * 2005-02-24 2006-08-31 Kemia, Inc. Modulators of gsk-3 activity
EP1991547A2 (en) * 2006-03-09 2008-11-19 Pharmacopeia, Inc. 8-heteroarylpurine mnk2 inhibitors for treating metabolic disorders

Also Published As

Publication number Publication date
WO2008051826A3 (en) 2008-10-02
IL198080A0 (en) 2009-12-24
CN101657453A (zh) 2010-02-24
WO2008051826A2 (en) 2008-05-02
JP2010507581A (ja) 2010-03-11
ECSP099342A (es) 2009-06-30
BRPI0717435A2 (pt) 2014-03-18
NO20091597L (no) 2009-07-14
CN101657453B (zh) 2013-06-12
US20110046131A1 (en) 2011-02-24
CA2666940A1 (en) 2008-05-02
EP2078019A2 (en) 2009-07-15
MX2009004154A (es) 2009-09-09
KR20090075854A (ko) 2009-07-09
CO6160294A2 (es) 2010-05-20
IN2009CN02154A (ko) 2015-08-07
RU2009118963A (ru) 2010-11-27
AU2007309167A1 (en) 2008-05-02

Similar Documents

Publication Publication Date Title
HK1139137A1 (en) Acylaminopyrazoles as fgfr inhibitors
ZA200902640B (en) Purines as PKC-Theta inhibitors
IL186445A0 (en) Dna-pk inhibitors
ZA200808282B (en) Uses of DPP-IV inhibitors
PT2402319T (pt) Inibidores de dgat
GB0619753D0 (en) Enzyme inhibitors
ZA200900109B (en) Pyrrolotriazine kinase inhibitors
IL198927A0 (en) Imidazopyridine inhibitors of iap
IL192603A0 (en) Thieno-pyridine derivatives as mek inhibitors
IL194339A0 (en) Enzyme inhibitors
IL200153A0 (en) Novel phosphodiesterase inhibitors
GB0621203D0 (en) PLK inhibitors
IL196000A0 (en) 2-arylindole derivatives as npges-i inhibitors
GB0608844D0 (en) Enzyme inhibitors
ZA200905371B (en) Novel phosphodiesterase Inhibitors
GB0617161D0 (en) Enzyme inhibitors
ZA200809113B (en) Pyrimidine derivatives as p13k inhibitors
IL197981A0 (en) Kinase inhibitors
IL196807A0 (en) Inhibitors for glyt-1
GB0622367D0 (en) Phosphodiesterase inhibitors
ZA200709467B (en) DNA-PK inhibitors
GB0507831D0 (en) DNA-PK inhibitors
GB0605548D0 (en) Cell inhibitor
GB0612544D0 (en) Enzyme inhibitors
GB0620884D0 (en) Enzyme inhibitors