IN2009CN02154A - - Google Patents
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- Publication number
- IN2009CN02154A IN2009CN02154A IN2154CHN2009A IN2009CN02154A IN 2009CN02154 A IN2009CN02154 A IN 2009CN02154A IN 2154CHN2009 A IN2154CHN2009 A IN 2154CHN2009A IN 2009CN02154 A IN2009CN02154 A IN 2009CN02154A
- Authority
- IN
- India
- Prior art keywords
- alkyl
- nr5r6
- proviso
- heteroatom
- chosen
- Prior art date
Links
- 0 Cc1c(C)cc(C*=C)cc1 Chemical compound Cc1c(C)cc(C*=C)cc1 0.000 description 7
- SOASYFLYKZHCCT-UHFFFAOYSA-N CC(CCc1ccccc1C)=C Chemical compound CC(CCc1ccccc1C)=C SOASYFLYKZHCCT-UHFFFAOYSA-N 0.000 description 1
- YJFATKLYOXCPBK-UHFFFAOYSA-N CCCC(CCC)CC[n]1c(-c(cc2)ccc2C#N)nc2c1nc(CCc(cccc1)c1Cl)nc2 Chemical compound CCCC(CCC)CC[n]1c(-c(cc2)ccc2C#N)nc2c1nc(CCc(cccc1)c1Cl)nc2 YJFATKLYOXCPBK-UHFFFAOYSA-N 0.000 description 1
- HSVUACDXZURDTL-WMCAAGNKSA-N CCCCCC(C)C([C@H]1C=CC=C(C)C1)=C Chemical compound CCCCCC(C)C([C@H]1C=CC=C(C)C1)=C HSVUACDXZURDTL-WMCAAGNKSA-N 0.000 description 1
- FYJXLWXSAMWFHW-UHFFFAOYSA-N CCCN(CC1)CC[O]1[I]1C([IH]C(NCC2C=CC=CC2F)NC2)=C2C=C1C1=C(C)C(C)CCC1 Chemical compound CCCN(CC1)CC[O]1[I]1C([IH]C(NCC2C=CC=CC2F)NC2)=C2C=C1C1=C(C)C(C)CCC1 FYJXLWXSAMWFHW-UHFFFAOYSA-N 0.000 description 1
- HPRMNOHMMYKHIW-JCZBKMKOSA-N CC[C@H](C)CC([C@@H](C)C[C@@H]1C)C1I Chemical compound CC[C@H](C)CC([C@@H](C)C[C@@H]1C)C1I HPRMNOHMMYKHIW-JCZBKMKOSA-N 0.000 description 1
- HYFLWBNQFMXCPA-UHFFFAOYSA-N CCc1c(C)cccc1 Chemical compound CCc1c(C)cccc1 HYFLWBNQFMXCPA-UHFFFAOYSA-N 0.000 description 1
- WBZPJYVOOIYMKI-YUZLPWPTSA-N C[C@@]12C(I)=C(CCCC=C)C#CC1C2 Chemical compound C[C@@]12C(I)=C(CCCC=C)C#CC1C2 WBZPJYVOOIYMKI-YUZLPWPTSA-N 0.000 description 1
- QTZGHUUECFAZQP-UHFFFAOYSA-N Fc(cc1)ccc1-c1nc2cnc(NCc(cccc3)c3Cl)nc2[n]1CCC1CCNCC1 Chemical compound Fc(cc1)ccc1-c1nc2cnc(NCc(cccc3)c3Cl)nc2[n]1CCC1CCNCC1 QTZGHUUECFAZQP-UHFFFAOYSA-N 0.000 description 1
- PREQZIDCLYIERV-UHFFFAOYSA-N Fc1c(C[N-]c2ncc(C=C(C3C4CCNCC4)c4ccccc4F)c3n2)cccc1 Chemical compound Fc1c(C[N-]c2ncc(C=C(C3C4CCNCC4)c4ccccc4F)c3n2)cccc1 PREQZIDCLYIERV-UHFFFAOYSA-N 0.000 description 1
- ZZMATCATVCPAJU-YRNVUSSQSA-N I/C=C/CCCCC1CCCCC1 Chemical compound I/C=C/CCCCC1CCCCC1 ZZMATCATVCPAJU-YRNVUSSQSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A compone. or N±:T ájersof, represenied by Formula I. (II) wherein: z R is chosen from C1-C4 alkyl, carbocyclyl. substitulcd carbocyclyl. and R4 wherein Rn is choser from cycloalkyl. cycloalkylalkyl. aryl. arylalkyl. heteroaryl, and heieroarylalkyl. wherein R1 may be substituted. wirh a proviso that when R is a heieroaryl, R is not bonded via a heteroatom to the methylene carbón bearíng the Z group; and Z is choscn from -H and O-Ci alkyl; R2 is chosen from -fC-C- alkyl)-NR5R6. -{CVC4 alkyl)-R7-Rs, and -ÍG.-C, aür.íh-CÍOMCy-Ci alkylV-R*—Rw. whereia with a proviso That when R is a heterocyclyl, a purine nitrogen of Formula 1 boocted to R" is not bonded to a heteroatom of R directly or via a mcúryienc group; R1 chosen from ÍCVQ alkyU-NR5]*6, and -C(0j—<Gr-C4 alkyl)—NR5R6, and. when R' is nitrogenous heterocyclyl, R" may addrrionally be -H. with a proviso that when R is a heterocyclyl and R is HCO-O alky[)-NR5R6, a heteroatom of R7 is not bonded to -NR5R6 directly or via a mcthylcnc group; Pace 155 of 173 ch over. from -H and CI-CJ aiky!; and R LS cnoien from I_A¡ uC.i. aryi. substimicc ¿ryí, arylaiky!. substinned ¿-yiaitkyL. hetsrD&r.i and >ubsiuuied heteroaryl: with a proviso thai when R" i> phenyl and R: is piperidin-4-yl-cthyl, R! is not cyclopropyl.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85339606P | 2006-10-20 | 2006-10-20 | |
| PCT/US2007/081899 WO2008051826A2 (en) | 2006-10-20 | 2007-10-19 | Purines as pkc-theta inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2009CN02154A true IN2009CN02154A (en) | 2015-08-07 |
Family
ID=39111415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2154CHN2009 IN2009CN02154A (en) | 2006-10-20 | 2007-10-19 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20110046131A1 (en) |
| EP (1) | EP2078019A2 (en) |
| JP (1) | JP2010507581A (en) |
| KR (1) | KR20090075854A (en) |
| CN (1) | CN101657453B (en) |
| AU (1) | AU2007309167A1 (en) |
| BR (1) | BRPI0717435A2 (en) |
| CA (1) | CA2666940A1 (en) |
| CO (1) | CO6160294A2 (en) |
| EC (1) | ECSP099342A (en) |
| IL (1) | IL198080A0 (en) |
| IN (1) | IN2009CN02154A (en) |
| MX (1) | MX2009004154A (en) |
| NO (1) | NO20091597L (en) |
| RU (1) | RU2009118963A (en) |
| WO (1) | WO2008051826A2 (en) |
| ZA (1) | ZA200902640B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090281075A1 (en) * | 2006-02-17 | 2009-11-12 | Pharmacopeia, Inc. | Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
| US7989459B2 (en) * | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
| MX2008011525A (en) * | 2006-03-09 | 2008-09-18 | Pharmacopeia Inc | 8-heteroarylpurine mnk2 inhibitors for treating metabolic disorders. |
| US20090170812A1 (en) * | 2006-06-23 | 2009-07-02 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| US20120295915A1 (en) * | 2009-11-24 | 2012-11-22 | Chaudhari Amita M | Azabenzimidazoles as fatty acid synthase inhibitors |
| CN102869664A (en) * | 2010-01-27 | 2013-01-09 | 沃泰克斯药物股份有限公司 | Pyrazolopyrimidine kinase inhibitors |
| CN103209695A (en) | 2010-09-15 | 2013-07-17 | 弗·哈夫曼-拉罗切有限公司 | Azabenzothiazole compounds, compositions and methods of use |
| KR20140082710A (en) * | 2011-09-20 | 2014-07-02 | 에프. 호프만-라 로슈 아게 | Imidazopyridine compounds, compositions and methods of use |
| US10485772B2 (en) | 2014-08-25 | 2019-11-26 | EpiAxis Therapeutics Pty Ltd. | Compositions for modulating cancer stem cells and uses therefor |
| EP3578549A4 (en) * | 2017-02-03 | 2021-01-13 | Tohoku University | Heterocyclic compound |
| EP3706776A4 (en) * | 2017-11-08 | 2021-08-11 | Epiaxis Therapeutics Pty Ltd | Immunogenic compositions and uses therefor |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0470543A1 (en) * | 1990-08-10 | 1992-02-12 | Dr. Karl Thomae GmbH | Heterocyclic imidazoles, remedies containing them and processes for their preparation |
| CA2309350C (en) * | 1997-11-12 | 2007-04-03 | Mitsubishi Chemical Corporation | Purine derivatives and medicaments comprising the same as active ingredient |
| US20050165232A1 (en) * | 2002-05-13 | 2005-07-28 | Richard Beresis | Phenyl substituted imidaopyridines and phenyl substituted benzimidazoles |
| JP2004217582A (en) * | 2003-01-16 | 2004-08-05 | Abbott Japan Co Ltd | 9h-purine derivative |
| RU2403254C2 (en) * | 2004-10-29 | 2010-11-10 | Тиботек Фармасьютикалз Лтд. | Hiv-inhibiting bicyclic pyrimidin derivatives |
| US7723340B2 (en) * | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| BRPI0607455A2 (en) * | 2005-02-16 | 2009-09-01 | Astrazeneca Ab | compound, process for preparing same, use of a compound, and pharmaceutical composition |
| WO2006091737A1 (en) * | 2005-02-24 | 2006-08-31 | Kemia, Inc. | Modulators of gsk-3 activity |
| MX2008011525A (en) * | 2006-03-09 | 2008-09-18 | Pharmacopeia Inc | 8-heteroarylpurine mnk2 inhibitors for treating metabolic disorders. |
-
2007
- 2007-10-19 KR KR1020097009128A patent/KR20090075854A/en not_active Application Discontinuation
- 2007-10-19 EP EP07844441A patent/EP2078019A2/en not_active Withdrawn
- 2007-10-19 BR BRPI0717435-7A patent/BRPI0717435A2/en not_active IP Right Cessation
- 2007-10-19 WO PCT/US2007/081899 patent/WO2008051826A2/en active Application Filing
- 2007-10-19 US US12/445,862 patent/US20110046131A1/en not_active Abandoned
- 2007-10-19 RU RU2009118963/04A patent/RU2009118963A/en not_active Application Discontinuation
- 2007-10-19 IN IN2154CHN2009 patent/IN2009CN02154A/en unknown
- 2007-10-19 CN CN2007800418805A patent/CN101657453B/en not_active Expired - Fee Related
- 2007-10-19 CA CA002666940A patent/CA2666940A1/en not_active Abandoned
- 2007-10-19 MX MX2009004154A patent/MX2009004154A/en not_active Application Discontinuation
- 2007-10-19 JP JP2009533556A patent/JP2010507581A/en active Pending
- 2007-10-19 AU AU2007309167A patent/AU2007309167A1/en not_active Abandoned
-
2009
- 2009-04-07 IL IL198080A patent/IL198080A0/en unknown
- 2009-04-16 ZA ZA200902640A patent/ZA200902640B/en unknown
- 2009-04-20 CO CO09039704A patent/CO6160294A2/en unknown
- 2009-04-22 NO NO20091597A patent/NO20091597L/en not_active Application Discontinuation
- 2009-05-18 EC EC2009009342A patent/ECSP099342A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP099342A (en) | 2009-06-30 |
| CN101657453A (en) | 2010-02-24 |
| CN101657453B (en) | 2013-06-12 |
| RU2009118963A (en) | 2010-11-27 |
| KR20090075854A (en) | 2009-07-09 |
| JP2010507581A (en) | 2010-03-11 |
| MX2009004154A (en) | 2009-09-09 |
| NO20091597L (en) | 2009-07-14 |
| IL198080A0 (en) | 2009-12-24 |
| AU2007309167A1 (en) | 2008-05-02 |
| WO2008051826A2 (en) | 2008-05-02 |
| BRPI0717435A2 (en) | 2014-03-18 |
| CO6160294A2 (en) | 2010-05-20 |
| ZA200902640B (en) | 2010-05-26 |
| US20110046131A1 (en) | 2011-02-24 |
| WO2008051826A3 (en) | 2008-10-02 |
| CA2666940A1 (en) | 2008-05-02 |
| EP2078019A2 (en) | 2009-07-15 |
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