ZA200902607B - Method for preparing Medetomidine and its salts - Google Patents

Method for preparing Medetomidine and its salts

Info

Publication number
ZA200902607B
ZA200902607B ZA200902607A ZA200902607A ZA200902607B ZA 200902607 B ZA200902607 B ZA 200902607B ZA 200902607 A ZA200902607 A ZA 200902607A ZA 200902607 A ZA200902607 A ZA 200902607A ZA 200902607 B ZA200902607 B ZA 200902607B
Authority
ZA
South Africa
Prior art keywords
salts
preparing medetomidine
medetomidine
preparing
transmetalation
Prior art date
Application number
ZA200902607A
Other languages
English (en)
Inventor
Reine Inese
Zandersons Armands
Original Assignee
Grindeks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindeks filed Critical Grindeks
Publication of ZA200902607B publication Critical patent/ZA200902607B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA200902607A 2006-11-06 2009-04-16 Method for preparing Medetomidine and its salts ZA200902607B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06123548A EP1918282A1 (en) 2006-11-06 2006-11-06 Method for preparing medetomidine and its salts

Publications (1)

Publication Number Publication Date
ZA200902607B true ZA200902607B (en) 2010-04-28

Family

ID=37770375

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200902607A ZA200902607B (en) 2006-11-06 2009-04-16 Method for preparing Medetomidine and its salts

Country Status (19)

Country Link
US (1) US7902377B2 (xx)
EP (2) EP1918282A1 (xx)
JP (1) JP2010508332A (xx)
KR (1) KR20090052398A (xx)
CN (1) CN101535272B (xx)
AT (1) ATE517094T1 (xx)
AU (1) AU2007316693B2 (xx)
BR (1) BRPI0714992A2 (xx)
CA (1) CA2660365C (xx)
DK (1) DK2079706T3 (xx)
EA (1) EA200900355A1 (xx)
ES (1) ES2369746T3 (xx)
MX (1) MX2009004649A (xx)
NZ (1) NZ575125A (xx)
PL (1) PL2079706T3 (xx)
PT (1) PT2079706E (xx)
SI (1) SI2079706T1 (xx)
WO (1) WO2008055852A1 (xx)
ZA (1) ZA200902607B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011070069A1 (en) 2009-12-09 2011-06-16 I-Tech Ab Process for preparation of medetomidine
CN102452984B (zh) * 2010-10-21 2013-10-23 桑迪亚医药技术（上海）有限责任公司 4-[1-(2,3-二甲基苯基)乙烯基]-1-r1-2-r2咪唑的合成方法
PL2734508T3 (pl) 2011-07-22 2018-08-31 Cambrex Karlskoga Ab Nowe sposoby wytwarzania 4-podstawionych imidazoli
SG11201405606RA (en) 2012-05-08 2014-11-27 Lonza Ag Method for preparation of medetomidine
KR101537204B1 (ko) 2012-05-08 2015-07-22 론자 아게 (론자 엘티디.) 2-(2,3-디메틸페닐)-1-프로파날의 제조 방법
WO2012172119A2 (en) 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
CN104245678B (zh) * 2012-06-28 2016-02-24 隆萨有限公司 用氯丙酮制备美托咪定的方法
WO2012172122A2 (en) 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
PL2867195T3 (pl) 2012-06-28 2016-06-30 Lonza Ag Sposób wytwarzania 2-(2,3-dimetylofenylo)-1-propanalu przy pomocy chloroacetonu
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
CN103588711B (zh) * 2013-11-27 2015-04-08 天津炜捷制药有限公司 一种美托咪定中间体的制备方法
CN103664788B (zh) * 2013-12-04 2015-11-25 湖北生物医药产业技术研究院有限公司 制备美托咪啶的方法
CN104447562A (zh) * 2014-03-27 2015-03-25 宁波天衡药业股份有限公司 一种制备盐酸右美托咪定关键中间体的新方法
CN106083724B (zh) * 2016-08-02 2018-06-26 江苏恒瑞医药股份有限公司 一种右美托咪定的制备方法
CN111269192A (zh) * 2020-02-25 2020-06-12 成都睿智化学研究有限公司 一种5-羟甲基四氮唑及其衍生物的合成方法
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
EP1797043A1 (en) * 2004-09-24 2007-06-20 Allergan, Inc. 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists
MX2007003094A (es) * 2004-09-24 2007-06-07 Allergan Inc 4-(metilo ciclico condensado)-imidazol-2-tionas como agonistas alfa2 adrenergicos.

Also Published As

Publication number Publication date
US7902377B2 (en) 2011-03-08
PT2079706E (pt) 2011-10-19
EP2079706A1 (en) 2009-07-22
MX2009004649A (es) 2009-05-21
CN101535272B (zh) 2011-10-05
ES2369746T3 (es) 2011-12-05
WO2008055852A8 (en) 2009-05-22
NZ575125A (en) 2011-02-25
WO2008055852A1 (en) 2008-05-15
AU2007316693A1 (en) 2008-05-15
CN101535272A (zh) 2009-09-16
DK2079706T3 (da) 2011-10-03
CA2660365C (en) 2014-03-25
EP2079706B1 (en) 2011-07-20
EP1918282A1 (en) 2008-05-07
AU2007316693B2 (en) 2012-02-02
CA2660365A1 (en) 2008-05-15
PL2079706T3 (pl) 2011-12-30
US20100048915A1 (en) 2010-02-25
KR20090052398A (ko) 2009-05-25
JP2010508332A (ja) 2010-03-18
EA200900355A1 (ru) 2009-10-30
ATE517094T1 (de) 2011-08-15
SI2079706T1 (sl) 2011-11-30
BRPI0714992A2 (pt) 2013-07-30

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