MX2009004649A - Metodo para preparar medetomidina y sus sales. - Google Patents

Metodo para preparar medetomidina y sus sales.

Info

Publication number
MX2009004649A
MX2009004649A MX2009004649A MX2009004649A MX2009004649A MX 2009004649 A MX2009004649 A MX 2009004649A MX 2009004649 A MX2009004649 A MX 2009004649A MX 2009004649 A MX2009004649 A MX 2009004649A MX 2009004649 A MX2009004649 A MX 2009004649A
Authority
MX
Mexico
Prior art keywords
salts
preparing medetomidine
medetomidine
preparing
transmetalation
Prior art date
Application number
MX2009004649A
Other languages
English (en)
Inventor
Inese Reine
Armands Zandersons
Original Assignee
Grindeks Jsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindeks Jsc filed Critical Grindeks Jsc
Publication of MX2009004649A publication Critical patent/MX2009004649A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere a un método mejorado altamente eficiente para preparar Medetomidina, y sus sales, en particular sus sales farmacéuticamente aceptables. El método utiliza la alta reactividad de imidazoles halogenados hacia la transmetalación con reactivos de Grignard y la reacción subsiguiente con 2,3-dimetilbenzaldehído.
MX2009004649A 2006-11-06 2007-11-02 Metodo para preparar medetomidina y sus sales. MX2009004649A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06123548A EP1918282A1 (en) 2006-11-06 2006-11-06 Method for preparing medetomidine and its salts
PCT/EP2007/061822 WO2008055852A1 (en) 2006-11-06 2007-11-02 Method for preparing medetomidine and its salts

Publications (1)

Publication Number Publication Date
MX2009004649A true MX2009004649A (es) 2009-05-21

Family

ID=37770375

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004649A MX2009004649A (es) 2006-11-06 2007-11-02 Metodo para preparar medetomidina y sus sales.

Country Status (19)

Country Link
US (1) US7902377B2 (es)
EP (2) EP1918282A1 (es)
JP (1) JP2010508332A (es)
KR (1) KR20090052398A (es)
CN (1) CN101535272B (es)
AT (1) ATE517094T1 (es)
AU (1) AU2007316693B2 (es)
BR (1) BRPI0714992A2 (es)
CA (1) CA2660365C (es)
DK (1) DK2079706T3 (es)
EA (1) EA200900355A1 (es)
ES (1) ES2369746T3 (es)
MX (1) MX2009004649A (es)
NZ (1) NZ575125A (es)
PL (1) PL2079706T3 (es)
PT (1) PT2079706E (es)
SI (1) SI2079706T1 (es)
WO (1) WO2008055852A1 (es)
ZA (1) ZA200902607B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753532B (zh) * 2009-12-09 2015-05-13 I-技术有限公司 美托咪定的制备方法
CN102452984B (zh) * 2010-10-21 2013-10-23 桑迪亚医药技术（上海）有限责任公司 4-[1-(2,3-二甲基苯基)乙烯基]-1-r1-2-r2咪唑的合成方法
IN2014DN00144A (es) 2011-07-22 2015-05-22 Cambrex Karlskoga Ab
PL2847173T3 (pl) * 2012-05-08 2016-06-30 Lonza Ag Sposób wytwarzania medetomidyny
WO2012172119A2 (en) 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
MY165212A (en) * 2012-05-08 2018-03-05 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1- propanal
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
DK2867195T3 (en) 2012-06-28 2016-04-04 Lonza Ag PROCESS FOR THE PREPARATION OF 2- (2,3-dimethylphenyl) -1-propanal WITH chloroacetone
WO2012172122A2 (en) 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
ES2565066T3 (es) * 2012-06-28 2016-03-31 Lonza Ltd Método para la preparación de medetomidina con cloroacetona
CN103588711B (zh) * 2013-11-27 2015-04-08 天津炜捷制药有限公司 一种美托咪定中间体的制备方法
CN103664788B (zh) * 2013-12-04 2015-11-25 湖北生物医药产业技术研究院有限公司 制备美托咪啶的方法
CN104447562A (zh) * 2014-03-27 2015-03-25 宁波天衡药业股份有限公司 一种制备盐酸右美托咪定关键中间体的新方法
CN106083724B (zh) * 2016-08-02 2018-06-26 江苏恒瑞医药股份有限公司 一种右美托咪定的制备方法
CN111269192A (zh) * 2020-02-25 2020-06-12 成都睿智化学研究有限公司 一种5-羟甲基四氮唑及其衍生物的合成方法
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
RU2383535C2 (ru) * 2004-09-24 2010-03-10 Аллерган, Инк. 4-(фенилметил и замещенный-фенилметил)-имидазол-2-тионы, действующие как специфические альфа2-адренергические агонисты
EP1791833A2 (en) * 2004-09-24 2007-06-06 Allergan, Inc. 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists

Also Published As

Publication number Publication date
EP2079706B1 (en) 2011-07-20
US20100048915A1 (en) 2010-02-25
WO2008055852A1 (en) 2008-05-15
CA2660365A1 (en) 2008-05-15
WO2008055852A8 (en) 2009-05-22
KR20090052398A (ko) 2009-05-25
EA200900355A1 (ru) 2009-10-30
JP2010508332A (ja) 2010-03-18
PT2079706E (pt) 2011-10-19
CA2660365C (en) 2014-03-25
EP2079706A1 (en) 2009-07-22
CN101535272A (zh) 2009-09-16
EP1918282A1 (en) 2008-05-07
ATE517094T1 (de) 2011-08-15
CN101535272B (zh) 2011-10-05
PL2079706T3 (pl) 2011-12-30
ZA200902607B (en) 2010-04-28
NZ575125A (en) 2011-02-25
SI2079706T1 (sl) 2011-11-30
US7902377B2 (en) 2011-03-08
AU2007316693B2 (en) 2012-02-02
ES2369746T3 (es) 2011-12-05
DK2079706T3 (da) 2011-10-03
BRPI0714992A2 (pt) 2013-07-30
AU2007316693A1 (en) 2008-05-15

Similar Documents

Publication Publication Date Title
MX2009004649A (es) Metodo para preparar medetomidina y sus sales.
IL258880A (en) Compounds of diarylhydantoin
AU2016204376A1 (en) MicroRNA-based methods and compositions for the diagnosis and treatment of ovarian cancer
UA107443C2 (uk) Хімічний спосіб
MY171841A (en) Antibody formulation
EP2214442B8 (en) Apparatus and method for coordinating the operations of discontinuous reception and the semi-persistent scheduling.
MX2010000465A (es) Metodos y composiciones para el tratamiento de cancer, tumores y alteraciones relacionadas con tumores.
TW200604843A (en) Location processing apparatus, systems, and methods
TW201129938A (en) Personal mapping system
PL2124381T3 (pl) Sposób, system i urządzenie do generowania klucza grupowego
TW200617019A (en) A process for the preparation of 7α-alkylated 19-norsteroids
MY150971A (en) Mineral amino acid polysaccharide complex
MY159491A (en) Disubstituted phthalazine hedgehog pathway antagonists
TW200619205A (en) A method for preparing irbesartan and intermediates thereof
TN2011000166A1 (en) Disubstituted phthalazine hedgehog pathway antagonists
EP1878714A4 (en) ORGANIC HYDRIDE SYNTHESIS DEVICE, ORGANIC HYDRIDE SYNTHESIS SYSTEM, AND HYDROGEN PRODUCTION DEVICE
SG145591A1 (en) System and method for electroplating metal components
EP2029615B8 (en) A process for the preparation of an oxaliplatin
WO2010148177A3 (en) Compounds, compositions, methods of synthesis, and methods of treatment
EP2099458A4 (en) COMPOUNDS AND METHODS FOR IMAGING AND THERAPY OF ENZYME-MEDIATED TUMORS
HK1122431A1 (en) Method and apparatus for remaining conversation information and database synchronization
UA29548U (en) Method for treating osteoarthrosis
UA42783U (ru) Способ лечения дисбактериоза
UA39992U (ru) Композиция для наполнения-гидрофобизации кожи
MX2009001158A (es) Sistema y metodo para la generacion automatica de un perfil de usuario a partir de informacion de localizacion.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal