ZA200902607B - Method for preparing Medetomidine and its salts - Google Patents

Method for preparing Medetomidine and its salts

Info

Publication number
ZA200902607B
ZA200902607B ZA200902607A ZA200902607A ZA200902607B ZA 200902607 B ZA200902607 B ZA 200902607B ZA 200902607 A ZA200902607 A ZA 200902607A ZA 200902607 A ZA200902607 A ZA 200902607A ZA 200902607 B ZA200902607 B ZA 200902607B
Authority
ZA
South Africa
Prior art keywords
salts
preparing medetomidine
medetomidine
preparing
transmetalation
Prior art date
Application number
ZA200902607A
Other languages
English (en)
Inventor
Reine Inese
Zandersons Armands
Original Assignee
Grindeks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindeks filed Critical Grindeks
Publication of ZA200902607B publication Critical patent/ZA200902607B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
ZA200902607A 2006-11-06 2009-04-16 Method for preparing Medetomidine and its salts ZA200902607B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06123548A EP1918282A1 (en) 2006-11-06 2006-11-06 Method for preparing medetomidine and its salts

Publications (1)

Publication Number Publication Date
ZA200902607B true ZA200902607B (en) 2010-04-28

Family

ID=37770375

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200902607A ZA200902607B (en) 2006-11-06 2009-04-16 Method for preparing Medetomidine and its salts

Country Status (19)

Country Link
US (1) US7902377B2 (es)
EP (2) EP1918282A1 (es)
JP (1) JP2010508332A (es)
KR (1) KR20090052398A (es)
CN (1) CN101535272B (es)
AT (1) ATE517094T1 (es)
AU (1) AU2007316693B2 (es)
BR (1) BRPI0714992A2 (es)
CA (1) CA2660365C (es)
DK (1) DK2079706T3 (es)
EA (1) EA200900355A1 (es)
ES (1) ES2369746T3 (es)
MX (1) MX2009004649A (es)
NZ (1) NZ575125A (es)
PL (1) PL2079706T3 (es)
PT (1) PT2079706E (es)
SI (1) SI2079706T1 (es)
WO (1) WO2008055852A1 (es)
ZA (1) ZA200902607B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753532B (zh) * 2009-12-09 2015-05-13 I-技术有限公司 美托咪定的制备方法
CN102452984B (zh) * 2010-10-21 2013-10-23 桑迪亚医药技术（上海）有限责任公司 4-[1-(2,3-二甲基苯基)乙烯基]-1-r1-2-r2咪唑的合成方法
IN2014DN00144A (es) 2011-07-22 2015-05-22 Cambrex Karlskoga Ab
CA2866424A1 (en) 2012-05-08 2013-01-24 Lonza Ltd. Method for preparation of medetomidine
CN104203893B (zh) 2012-05-08 2016-02-03 隆萨有限公司 2-(2,3-二甲基苯基)-1-丙醛的制备方法
WO2012172119A2 (en) 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
PL2867211T3 (pl) * 2012-06-28 2016-06-30 Lonza Ag Sposób wytwarzania medetomidyny przy pomocy chloroacetonu
ES2565065T3 (es) 2012-06-28 2016-03-31 Lonza Ltd Método para la preparación de 2-(2,3-dimetilfenil)-1-propanal con cloroacetona
WO2012172122A2 (en) 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
CN103588711B (zh) 2013-11-27 2015-04-08 天津炜捷制药有限公司 一种美托咪定中间体的制备方法
CN103664788B (zh) * 2013-12-04 2015-11-25 湖北生物医药产业技术研究院有限公司 制备美托咪啶的方法
CN104447562A (zh) * 2014-03-27 2015-03-25 宁波天衡药业股份有限公司 一种制备盐酸右美托咪定关键中间体的新方法
CN106083724B (zh) * 2016-08-02 2018-06-26 江苏恒瑞医药股份有限公司 一种右美托咪定的制备方法
CN111269192A (zh) * 2020-02-25 2020-06-12 成都睿智化学研究有限公司 一种5-羟甲基四氮唑及其衍生物的合成方法
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
CN101052638B (zh) * 2004-09-24 2011-01-19 阿勒根公司 作为α2肾上腺素能激动剂的4-（缩合环甲基）-咪唑-2-硫酮
RU2383535C2 (ru) * 2004-09-24 2010-03-10 Аллерган, Инк. 4-(фенилметил и замещенный-фенилметил)-имидазол-2-тионы, действующие как специфические альфа2-адренергические агонисты

Also Published As

Publication number Publication date
EA200900355A1 (ru) 2009-10-30
BRPI0714992A2 (pt) 2013-07-30
ATE517094T1 (de) 2011-08-15
CA2660365C (en) 2014-03-25
NZ575125A (en) 2011-02-25
EP2079706A1 (en) 2009-07-22
US20100048915A1 (en) 2010-02-25
KR20090052398A (ko) 2009-05-25
CN101535272B (zh) 2011-10-05
DK2079706T3 (da) 2011-10-03
JP2010508332A (ja) 2010-03-18
CN101535272A (zh) 2009-09-16
CA2660365A1 (en) 2008-05-15
EP1918282A1 (en) 2008-05-07
US7902377B2 (en) 2011-03-08
MX2009004649A (es) 2009-05-21
ES2369746T3 (es) 2011-12-05
EP2079706B1 (en) 2011-07-20
WO2008055852A8 (en) 2009-05-22
AU2007316693B2 (en) 2012-02-02
WO2008055852A1 (en) 2008-05-15
AU2007316693A1 (en) 2008-05-15
SI2079706T1 (sl) 2011-11-30
PL2079706T3 (pl) 2011-12-30
PT2079706E (pt) 2011-10-19

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