PT2079706E - Método para preparar medetomidina e seus sais - Google Patents

Método para preparar medetomidina e seus sais Download PDF

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Publication number
PT2079706E
PT2079706E PT07822154T PT07822154T PT2079706E PT 2079706 E PT2079706 E PT 2079706E PT 07822154 T PT07822154 T PT 07822154T PT 07822154 T PT07822154 T PT 07822154T PT 2079706 E PT2079706 E PT 2079706E
Authority
PT
Portugal
Prior art keywords
salts
preparing medetomidine
medetomidine
preparing
transmetalation
Prior art date
Application number
PT07822154T
Other languages
English (en)
Inventor
Inese Reine
Armands Zandersons
Original Assignee
Grindeks Jsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindeks Jsc filed Critical Grindeks Jsc
Publication of PT2079706E publication Critical patent/PT2079706E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT07822154T 2006-11-06 2007-11-02 Método para preparar medetomidina e seus sais PT2079706E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06123548A EP1918282A1 (en) 2006-11-06 2006-11-06 Method for preparing medetomidine and its salts

Publications (1)

Publication Number Publication Date
PT2079706E true PT2079706E (pt) 2011-10-19

Family

ID=37770375

Family Applications (1)

Application Number Title Priority Date Filing Date
PT07822154T PT2079706E (pt) 2006-11-06 2007-11-02 Método para preparar medetomidina e seus sais

Country Status (19)

Country Link
US (1) US7902377B2 (pt)
EP (2) EP1918282A1 (pt)
JP (1) JP2010508332A (pt)
KR (1) KR20090052398A (pt)
CN (1) CN101535272B (pt)
AT (1) ATE517094T1 (pt)
AU (1) AU2007316693B2 (pt)
BR (1) BRPI0714992A2 (pt)
CA (1) CA2660365C (pt)
DK (1) DK2079706T3 (pt)
EA (1) EA200900355A1 (pt)
ES (1) ES2369746T3 (pt)
MX (1) MX2009004649A (pt)
NZ (1) NZ575125A (pt)
PL (1) PL2079706T3 (pt)
PT (1) PT2079706E (pt)
SI (1) SI2079706T1 (pt)
WO (1) WO2008055852A1 (pt)
ZA (1) ZA200902607B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753532B (zh) * 2009-12-09 2015-05-13 I-技术有限公司 美托咪定的制备方法
CN102452984B (zh) * 2010-10-21 2013-10-23 桑迪亚医药技术（上海）有限责任公司 4-[1-(2,3-二甲基苯基)乙烯基]-1-r1-2-r2咪唑的合成方法
IN2014DN00144A (pt) 2011-07-22 2015-05-22 Cambrex Karlskoga Ab
IN2014DN07983A (pt) 2012-05-08 2015-05-01 Lonza Ag
WO2012172119A2 (en) 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
SG11201405611SA (en) 2012-05-08 2014-11-27 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal
US9156793B2 (en) * 2012-06-28 2015-10-13 Lonza Ltd. Method for preparation of medetomidine with chloroacetone
WO2012172122A2 (en) 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
KR101537203B1 (ko) * 2012-06-28 2015-07-22 론자 아게 (론자 엘티디.) 2-(2,3-디메틸페닐)-1-프로파날의 클로로아세톤으로의 제조 방법
CN103588711B (zh) * 2013-11-27 2015-04-08 天津炜捷制药有限公司 一种美托咪定中间体的制备方法
CN103664788B (zh) * 2013-12-04 2015-11-25 湖北生物医药产业技术研究院有限公司 制备美托咪啶的方法
CN104447562A (zh) * 2014-03-27 2015-03-25 宁波天衡药业股份有限公司 一种制备盐酸右美托咪定关键中间体的新方法
CN106083724B (zh) * 2016-08-02 2018-06-26 江苏恒瑞医药股份有限公司 一种右美托咪定的制备方法
CN111269192A (zh) * 2020-02-25 2020-06-12 成都睿智化学研究有限公司 一种5-羟甲基四氮唑及其衍生物的合成方法
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
NZ553290A (en) * 2004-09-24 2010-11-26 Allergan Inc 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
JP2008514601A (ja) * 2004-09-24 2008-05-08 アラーガン、インコーポレイテッド 特異的α２アドレナリン作動剤としての４−（フェニルメチルおよび置換フェニルメチル）−イミダゾール−２−チオン

Also Published As

Publication number Publication date
KR20090052398A (ko) 2009-05-25
US20100048915A1 (en) 2010-02-25
PL2079706T3 (pl) 2011-12-30
CA2660365A1 (en) 2008-05-15
DK2079706T3 (da) 2011-10-03
AU2007316693B2 (en) 2012-02-02
ATE517094T1 (de) 2011-08-15
AU2007316693A1 (en) 2008-05-15
EP2079706B1 (en) 2011-07-20
EP1918282A1 (en) 2008-05-07
BRPI0714992A2 (pt) 2013-07-30
MX2009004649A (es) 2009-05-21
CA2660365C (en) 2014-03-25
ES2369746T3 (es) 2011-12-05
WO2008055852A1 (en) 2008-05-15
CN101535272B (zh) 2011-10-05
ZA200902607B (en) 2010-04-28
EP2079706A1 (en) 2009-07-22
CN101535272A (zh) 2009-09-16
JP2010508332A (ja) 2010-03-18
WO2008055852A8 (en) 2009-05-22
NZ575125A (en) 2011-02-25
SI2079706T1 (sl) 2011-11-30
US7902377B2 (en) 2011-03-08
EA200900355A1 (ru) 2009-10-30

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