ZA200900905B - Modified-galactosyl ceramides for staining and stimulating Natural Killer T cells - Google Patents

Modified-galactosyl ceramides for staining and stimulating Natural Killer T cells

Info

Publication number
ZA200900905B
ZA200900905B ZA200900905A ZA200900905A ZA200900905B ZA 200900905 B ZA200900905 B ZA 200900905B ZA 200900905 A ZA200900905 A ZA 200900905A ZA 200900905 A ZA200900905 A ZA 200900905A ZA 200900905 B ZA200900905 B ZA 200900905B
Authority
ZA
South Africa
Prior art keywords
staining
cells
modified
natural killer
stimulating natural
Prior art date
Application number
ZA200900905A
Other languages
English (en)
Inventor
Paul B Savage
Luc Teyton
Albert Bendelac
Original Assignee
Scripps Research Inst
Univ Brigham Young
Univ Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst, Univ Brigham Young, Univ Chicago filed Critical Scripps Research Inst
Publication of ZA200900905B publication Critical patent/ZA200900905B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA200900905A 2006-04-07 2009-02-06 Modified-galactosyl ceramides for staining and stimulating Natural Killer T cells ZA200900905B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79009606P 2006-04-07 2006-04-07

Publications (1)

Publication Number Publication Date
ZA200900905B true ZA200900905B (en) 2010-06-30

Family

ID=38581864

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200900905A ZA200900905B (en) 2006-04-07 2009-02-06 Modified-galactosyl ceramides for staining and stimulating Natural Killer T cells

Country Status (12)

Country Link
US (2) US8227581B2 (xx)
EP (1) EP2056842B1 (xx)
AU (1) AU2007234753B2 (xx)
BR (1) BRPI0710668A2 (xx)
CA (1) CA2661789C (xx)
DK (1) DK2056842T3 (xx)
ES (1) ES2397975T3 (xx)
PL (1) PL2056842T3 (xx)
PT (1) PT2056842E (xx)
SI (1) SI2056842T1 (xx)
WO (1) WO2007118234A2 (xx)
ZA (1) ZA200900905B (xx)

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EP1848813B1 (en) 2005-01-28 2013-04-10 Brigham Young University Bacterial glycolipid activation of cd1d-restricted nkt cells
US7794722B2 (en) 2006-06-30 2010-09-14 The Scripps Research Institute Adjuvants and methods of use
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
AU2013202865B2 (en) * 2007-11-07 2015-03-19 Abivax Increase of immune response and targeting by antigens and/or drug linkage
EP2058011A1 (en) * 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
KR101566847B1 (ko) * 2007-12-05 2015-11-06 아비박스 항원에 대한 면역 반응 증강을 위한 글리코실세라마이드의 용도
US9220767B2 (en) 2008-10-08 2015-12-29 Abivax Vaccine composition for use against influenza
ES2345377B1 (es) * 2009-03-20 2011-07-21 Consejo Superior De Investigaciones Cientificas (Csis) (51%) Compuestos aminociclitoles, procedimiento de obtencion y usos.
CA2792754C (en) 2010-03-12 2019-11-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services .beta.-mannosylceramide and stimulation of nkt cell anti-tumor immunity
WO2013162016A1 (ja) 2012-04-26 2013-10-31 独立行政法人理化学研究所 新規カルバメート糖脂質およびその用途
US9321796B2 (en) 2012-06-28 2016-04-26 Universiteit Gent Galactopyranosyl derivatives useful as medicaments
EP2727929A1 (en) * 2012-10-30 2014-05-07 Wittycell Method of preparation of alpha galactosyl ceramides compounds
US20170029454A1 (en) * 2013-06-28 2017-02-02 The Scripps Research Institute Nkt cell ligands and methods of use
US10046046B2 (en) * 2014-06-05 2018-08-14 Victoria Link Limited Amino sphingoglycolipid analogues
CA3036598A1 (en) 2016-09-14 2018-03-22 Abivax Combinations including abx196 for the treatment of cancer
WO2019190986A1 (en) * 2018-03-26 2019-10-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 3-o-sulfo-galactosylceramide analogs as activators of type ii nkt cells and uses thereof
WO2023121483A1 (en) * 2021-12-24 2023-06-29 Victoria Link Limited Immunostimulatory compositions
CN115286667B (zh) * 2022-08-02 2024-03-26 华中农业大学 一种α-半乳糖基神经酰胺类似物及其制备方法和应用

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US7645873B2 (en) * 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
CA2519568C (en) * 2003-03-20 2012-01-03 Brigham Young University 6"-amino-6"-deoxygalactosylceramides
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US7771726B2 (en) * 2003-10-08 2010-08-10 New York University Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases
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US7998739B2 (en) * 2004-09-03 2011-08-16 The Scipps Research Institute Methods of activating NKT cells
AU2005322027B2 (en) * 2004-12-28 2013-09-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NK Tcells
EP1848813B1 (en) 2005-01-28 2013-04-10 Brigham Young University Bacterial glycolipid activation of cd1d-restricted nkt cells
KR100764678B1 (ko) 2005-07-13 2007-10-09 재단법인서울대학교산학협력재단 알파-갈락토실세라마이드를 아쥬반트로 포함하는 비강투여용 백신 조성물
CA2626997C (en) 2005-10-25 2014-12-23 Ludwig Institute For Cancer Research Analogs of alpha galactosylceramide and uses thereof
US7794722B2 (en) * 2006-06-30 2010-09-14 The Scripps Research Institute Adjuvants and methods of use
EP1938836A1 (en) 2006-12-28 2008-07-02 Universite Rene Descartes (Paris V) Compositions comprising a B subunit of shiga toxin and a means stimulating NKT cells

Also Published As

Publication number Publication date
SI2056842T1 (sl) 2013-02-28
CA2661789A1 (en) 2007-10-18
BRPI0710668A2 (pt) 2011-08-16
AU2007234753A1 (en) 2007-10-18
WO2007118234A2 (en) 2007-10-18
PT2056842E (pt) 2013-01-24
EP2056842A2 (en) 2009-05-13
PL2056842T3 (pl) 2013-03-29
US8227581B2 (en) 2012-07-24
CA2661789C (en) 2014-06-03
US20120270815A1 (en) 2012-10-25
US20090047299A1 (en) 2009-02-19
EP2056842B1 (en) 2012-10-17
AU2007234753B2 (en) 2013-02-21
US8765692B2 (en) 2014-07-01
WO2007118234A3 (en) 2007-12-06
ES2397975T3 (es) 2013-03-12
DK2056842T3 (da) 2013-01-14
EP2056842A4 (en) 2010-10-06

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