ZA200900707B - Substituted spiroketal derivatives and use thereof as therapeutic drug for diabetes - Google Patents
Substituted spiroketal derivatives and use thereof as therapeutic drug for diabetesInfo
- Publication number
- ZA200900707B ZA200900707B ZA200900707A ZA200900707A ZA200900707B ZA 200900707 B ZA200900707 B ZA 200900707B ZA 200900707 A ZA200900707 A ZA 200900707A ZA 200900707 A ZA200900707 A ZA 200900707A ZA 200900707 B ZA200900707 B ZA 200900707B
- Authority
- ZA
- South Africa
- Prior art keywords
- diabetes
- substituted
- therapeutic drug
- spiroketal derivatives
- spiroketal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006205153 | 2006-07-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200900707B true ZA200900707B (en) | 2010-05-26 |
Family
ID=38981590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200900707A ZA200900707B (en) | 2006-07-27 | 2007-07-27 | Substituted spiroketal derivatives and use thereof as therapeutic drug for diabetes |
Country Status (18)
Country | Link |
---|---|
US (1) | US20110275703A1 (fr) |
EP (1) | EP2048153A4 (fr) |
JP (1) | JP5165566B2 (fr) |
KR (1) | KR20090033494A (fr) |
CN (1) | CN101495495A (fr) |
AR (1) | AR062109A1 (fr) |
AU (1) | AU2007277707A1 (fr) |
BR (1) | BRPI0715363A2 (fr) |
CA (1) | CA2658923A1 (fr) |
CL (1) | CL2007002187A1 (fr) |
IL (1) | IL196586A0 (fr) |
MX (1) | MX2009000578A (fr) |
NO (1) | NO20090172L (fr) |
PE (1) | PE20080731A1 (fr) |
RU (1) | RU2009106858A (fr) |
TW (1) | TWI403516B (fr) |
WO (1) | WO2008013280A1 (fr) |
ZA (1) | ZA200900707B (fr) |
Families Citing this family (35)
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---|---|---|---|---|
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
TW201011043A (en) | 2008-06-20 | 2010-03-16 | Chugai Pharmaceutical Co Ltd | Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives |
ME01285A (me) * | 2008-08-28 | 2013-06-20 | Pfizer | Derivati dioksa-bicikl0[3.2.1]oktan-2,3,4-triola |
CA2777857C (fr) * | 2009-11-02 | 2014-12-02 | Pfizer Inc. | Derives dioxa-bicyclo[3.2.1]octane-2,3,4-triol |
WO2011074675A1 (fr) * | 2009-12-18 | 2011-06-23 | 中外製薬株式会社 | Procédé de préparation d'un dérivé spirocétal |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
WO2011157827A1 (fr) | 2010-06-18 | 2011-12-22 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
WO2012041898A1 (fr) | 2010-09-29 | 2012-04-05 | Celon Pharma Sp. Z O.O. | Combinaison de l'inhibiteur de sglt2 et d'un composé de sucre pour le traitement du diabète |
US20120283169A1 (en) | 2010-11-08 | 2012-11-08 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US20130035281A1 (en) | 2011-02-09 | 2013-02-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
CA2837627A1 (fr) | 2011-06-03 | 2012-12-06 | Boehringer Ingelheim International Gmbh | Inhibiteurs de sglt-2 pour traiter des troubles metaboliques chez des patients traites avec des agents neuroleptiques |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
WO2013045413A1 (fr) | 2011-09-27 | 2013-04-04 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
WO2013151033A1 (fr) * | 2012-04-03 | 2013-10-10 | 第一三共株式会社 | Dérivé de c-glycoside présentant un cycle spiro |
US9193751B2 (en) | 2012-04-10 | 2015-11-24 | Theracos, Inc. | Process for the preparation of benzylbenzene SGLT2 inhibitors |
HUE064190T2 (hu) | 2013-04-04 | 2024-03-28 | Boehringer Ingelheim Vetmedica Gmbh | Lófélék anyagcserezavarainak kezelése |
CN111494357A (zh) | 2013-12-17 | 2020-08-07 | 勃林格殷格翰动物保健有限公司 | 猫科动物中代谢紊乱的治疗 |
KR102414283B1 (ko) | 2014-01-23 | 2022-06-29 | 베링거잉겔하임베트메디카게엠베하 | 개과 동물에서 대사 장애의 치료 |
MX2016012705A (es) | 2014-04-01 | 2016-12-16 | Boehringer Ingelheim Vetmedica Gmbh | Tratamiento de trastornos metabolicos en animales equinos. |
CN106317068A (zh) * | 2015-06-23 | 2017-01-11 | 中国科学院上海药物研究所 | 一种c,o-螺环芳基糖苷类化合物及其制备和应用 |
PT3788116T (pt) | 2018-05-04 | 2022-09-22 | Univ Do Porto | Fotossensibilizadores quimioluminescentes à base de imidazopirazinona com estados excitados de singleto e tripleto disponíveis |
WO2020039394A1 (fr) | 2018-08-24 | 2020-02-27 | Novartis Ag | Nouvelles combinaisons de médicaments |
EP4064854A1 (fr) | 2019-11-28 | 2022-10-05 | Boehringer Ingelheim Vetmedica GmbH | Utilisation d'inhibiteurs de sglt-2 dans le séchage de mammifères non humains |
WO2021165177A1 (fr) | 2020-02-17 | 2021-08-26 | Boehringer Ingelheim Vetmedica Gmbh | Utilisation d'inhibiteurs de sglt-2 pour la prévention et/ou le traitement de maladies cardiaques chez les félins |
CN113429379A (zh) * | 2021-06-28 | 2021-09-24 | 江苏法安德医药科技有限公司 | 一种lh-1801中间体及其制备方法和应用 |
CA3223537A1 (fr) | 2021-07-28 | 2023-02-02 | Boehringer Ingelheim Vetmedica Gmbh | Utilisation d'inhibiteurs de sglt-2 pour la prevention et/ou le traitement de maladies cardiaques chez des mammiferes non humains a l'exclusion de felins, en particulier des canides |
WO2023006745A1 (fr) | 2021-07-28 | 2023-02-02 | Boehringer Ingelheim Vetmedica Gmbh | Utilisation d'inhibiteurs de sglt-2 pour la prévention et/ou le traitement de l'hypertension chez des mammifères non humains |
KR20240040106A (ko) | 2021-07-28 | 2024-03-27 | 베링거잉겔하임베트메디카게엠베하 | 비-사람 포유류에서 신장 질환의 예방 및/또는 치료를 위한 sglt-2 억제제의 용도 |
CN115873048A (zh) * | 2021-09-26 | 2023-03-31 | 南京华威医药科技集团有限公司 | 托格列净氧化杂质的制备方法 |
WO2023129595A1 (fr) | 2021-12-30 | 2023-07-06 | Newamsterdam Pharma B.V. | Combinaison d'obicetrapib et d'inhibiteur de sglt2 |
US20230381101A1 (en) | 2022-05-25 | 2023-11-30 | Boehringer Ingelheim Vetmedica Gmbh | Aqueous pharmaceutical compositions comprising sglt-2 inhibitors |
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CN1020944C (zh) * | 1990-01-30 | 1993-05-26 | 阿图尔-费希尔股份公司费希尔厂 | 紧固件 |
US5470845A (en) | 1992-10-28 | 1995-11-28 | Bristol-Myers Squibb Company | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia |
US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
JP2000080041A (ja) | 1998-03-09 | 2000-03-21 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
US6627611B2 (en) | 2000-02-02 | 2003-09-30 | Kotobuki Pharmaceutical Co Ltd | C-glycosides and preparation of thereof as antidiabetic agents |
PL205605B1 (pl) | 2000-03-17 | 2010-05-31 | Kissei Pharmaceutical | Pochodna glukopiranozyloksybenzylobenzenu, kompozycja farmaceutyczna, zastosowanie tej pochodnej do wytwarzania kompozycji oraz pochodna benzylofenolu |
HUP0600232A2 (en) | 2001-04-11 | 2006-08-28 | Bristol Myers Squibb Co | Amino acid complexes of c-aryl glucosides for treatment of diabetes and method |
DE10231370B4 (de) | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
TWI254635B (en) | 2002-08-05 | 2006-05-11 | Yamanouchi Pharma Co Ltd | Azulene derivative and salt thereof |
PL1609785T3 (pl) | 2003-03-14 | 2016-07-29 | Astellas Pharma Inc | Pochodne c-glikozydowe i ich sole |
ES2844401T3 (es) * | 2003-08-01 | 2021-07-22 | Mitsubishi Tanabe Pharma Corp | Compuestos novedosos que tienen actividad inhibidora frente a transportador de glucosa dependiente de sodio |
EP1679965A4 (fr) | 2003-08-01 | 2009-05-27 | Janssen Pharmaceutica Nv | C-glycosides heterocycliques fusionnes substitues |
NZ549219A (en) | 2004-03-04 | 2010-08-27 | Kissei Pharmaceutical | Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof |
SI1730131T1 (sl) | 2004-03-16 | 2012-08-31 | Boehringer Ingelheim Int | Glukopiranozil-substituirani benzenski derivati, zdravila, ki vsebujejo te spojine, njihova uporaba in postopek za njihovo pripravo |
US7393836B2 (en) | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
DE102004034690A1 (de) | 2004-07-17 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
EP1773800A1 (fr) | 2004-07-27 | 2007-04-18 | Boehringer Ingelheim International GmbH | Cyclenes substitues par d-glucopyranosyle-phenyle, medicaments contenant lesdits composes, leur utilisation et procede de production correspondant |
WO2006018150A1 (fr) | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Cycles a substitution d-xylopyranosyl-phenyle, medicaments contenant ces composes, leur utilisation, et leur procede de production |
AR051446A1 (es) * | 2004-09-23 | 2007-01-17 | Bristol Myers Squibb Co | Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2) |
DE102004048388A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
TW200637869A (en) * | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
US7803778B2 (en) * | 2006-05-23 | 2010-09-28 | Theracos, Inc. | Glucose transport inhibitors and methods of use |
-
2007
- 2007-07-05 TW TW096124510A patent/TWI403516B/zh not_active IP Right Cessation
- 2007-07-26 AR ARP070103314A patent/AR062109A1/es not_active Application Discontinuation
- 2007-07-26 CL CL200702187A patent/CL2007002187A1/es unknown
- 2007-07-26 PE PE2007000984A patent/PE20080731A1/es not_active Application Discontinuation
- 2007-07-27 RU RU2009106858/04A patent/RU2009106858A/ru not_active Application Discontinuation
- 2007-07-27 EP EP07791500A patent/EP2048153A4/fr not_active Withdrawn
- 2007-07-27 ZA ZA200900707A patent/ZA200900707B/xx unknown
- 2007-07-27 KR KR1020097004056A patent/KR20090033494A/ko not_active Application Discontinuation
- 2007-07-27 BR BRPI0715363-5A patent/BRPI0715363A2/pt not_active IP Right Cessation
- 2007-07-27 MX MX2009000578A patent/MX2009000578A/es not_active Application Discontinuation
- 2007-07-27 US US12/375,363 patent/US20110275703A1/en not_active Abandoned
- 2007-07-27 JP JP2008526838A patent/JP5165566B2/ja not_active Expired - Fee Related
- 2007-07-27 WO PCT/JP2007/064806 patent/WO2008013280A1/fr active Application Filing
- 2007-07-27 AU AU2007277707A patent/AU2007277707A1/en not_active Abandoned
- 2007-07-27 CN CNA2007800281446A patent/CN101495495A/zh active Pending
- 2007-07-27 CA CA002658923A patent/CA2658923A1/fr not_active Abandoned
-
2009
- 2009-01-12 NO NO20090172A patent/NO20090172L/no not_active Application Discontinuation
- 2009-01-19 IL IL196586A patent/IL196586A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2009000578A (es) | 2009-01-27 |
US20110275703A1 (en) | 2011-11-10 |
TW200817425A (en) | 2008-04-16 |
RU2009106858A (ru) | 2010-09-10 |
NO20090172L (no) | 2009-04-27 |
CN101495495A (zh) | 2009-07-29 |
EP2048153A4 (fr) | 2013-01-23 |
AR062109A1 (es) | 2008-10-15 |
CA2658923A1 (fr) | 2008-01-31 |
CL2007002187A1 (es) | 2008-02-01 |
TWI403516B (zh) | 2013-08-01 |
JP5165566B2 (ja) | 2013-03-21 |
IL196586A0 (en) | 2009-11-18 |
BRPI0715363A2 (pt) | 2013-06-18 |
WO2008013280A1 (fr) | 2008-01-31 |
KR20090033494A (ko) | 2009-04-03 |
AU2007277707A1 (en) | 2008-01-31 |
JPWO2008013280A1 (ja) | 2009-12-17 |
EP2048153A1 (fr) | 2009-04-15 |
PE20080731A1 (es) | 2008-06-28 |
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