ZA200805240B - Pyrazoles for the treatment of gerd and IBS - Google Patents
Pyrazoles for the treatment of gerd and IBSInfo
- Publication number
- ZA200805240B ZA200805240B ZA200805240A ZA200805240A ZA200805240B ZA 200805240 B ZA200805240 B ZA 200805240B ZA 200805240 A ZA200805240 A ZA 200805240A ZA 200805240 A ZA200805240 A ZA 200805240A ZA 200805240 B ZA200805240 B ZA 200805240B
- Authority
- ZA
- South Africa
- Prior art keywords
- gerd
- ibs
- pyrazoles
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0502908 | 2005-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200805240B true ZA200805240B (en) | 2009-04-29 |
Family
ID=38188928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200805240A ZA200805240B (en) | 2005-12-23 | 2008-06-17 | Pyrazoles for the treatment of gerd and IBS |
Country Status (12)
Country | Link |
---|---|
US (1) | US20090062365A1 (xx) |
EP (1) | EP1966150A4 (xx) |
JP (1) | JP2009521427A (xx) |
KR (1) | KR20080090449A (xx) |
CN (1) | CN101341128A (xx) |
AU (1) | AU2006327314A1 (xx) |
BR (1) | BRPI0620415A2 (xx) |
CA (1) | CA2632011A1 (xx) |
IL (1) | IL191765A0 (xx) |
NO (1) | NO20083243L (xx) |
WO (1) | WO2007073297A1 (xx) |
ZA (1) | ZA200805240B (xx) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0401653D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
AU2006327316A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Imidazoles as GABA-B receptor modulators |
KR20080080214A (ko) * | 2005-12-23 | 2008-09-02 | 아스트라제네카 아베 | 헤테로시클릭 gaba-b 조절제 |
JP2009521428A (ja) * | 2005-12-23 | 2009-06-04 | アストラゼネカ・アクチエボラーグ | 胃腸疾患治療用のイミダゾール誘導体 |
JP2009521430A (ja) * | 2005-12-23 | 2009-06-04 | アストラゼネカ・アクチエボラーグ | Gaba−b受容体モジュレーター |
CN105101800B (zh) | 2012-10-02 | 2018-04-13 | 拜耳农作物科学股份公司 | 作为杀虫剂的杂环化合物 |
TW201623257A (zh) | 2014-05-09 | 2016-07-01 | 奧利安公司 | 藥理活性之喹唑啉二酮衍生物 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3876655A (en) * | 1971-08-18 | 1975-04-08 | Beecham Group Ltd | Anti-inflammatory acyl imidazoles |
US3833582A (en) * | 1972-08-21 | 1974-09-03 | Pfizer | Herbicidal 1h-pyrazolo(3,4-d)pyrimidin-4-ones |
US3910907A (en) * | 1973-07-09 | 1975-10-07 | Icn Pharmaceuticals | Pyrazolo(1,5-a)-1,3,5-triazines |
FR2264015A1 (en) * | 1974-03-13 | 1975-10-10 | Pfizer | Pyrazolo(3,4-d)pyrimidin-4-ones - pre-and post-emergence herbicides |
JPS5758670A (en) * | 1980-09-25 | 1982-04-08 | Otsuka Chem Co Ltd | 1-methyl-3-(n-substituted-n-chloroacetylamino)pyrazole-4-carboxylic acid ester derivative |
US4659720A (en) * | 1982-12-20 | 1987-04-21 | Merck & Co., Inc. | 5-amino or substituted amino imidazoles useful to treat coccidiosis |
DD240013A1 (de) * | 1985-04-01 | 1986-10-15 | Univ Halle Wittenberg | Verfahren zur herstellung von n-(1h-pyrazol-3-yl)-oxamaten |
FR2663934B1 (fr) * | 1990-06-27 | 1994-06-03 | Adir | Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent. |
US5214063A (en) * | 1990-06-27 | 1993-05-25 | Adir Et Compagnie | 4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors |
US5201938A (en) * | 1991-07-19 | 1993-04-13 | Dowelanco | N-pyrazolyl-1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides |
DE4213750A1 (de) * | 1992-04-25 | 1993-10-28 | Basf Ag | Verfahren zur Herstellung von 3-(Hydroxyphenyl)-propionaldehyden und gegebenenfalls der Herstellung von 3-(hydroxyphenyl)-propanolen |
SE9603408D0 (sv) * | 1996-09-18 | 1996-09-18 | Astra Ab | Medical use |
JP2002502380A (ja) * | 1997-05-22 | 2002-01-22 | ジー.ディー.サール アンド カンパニー | p38キナーゼ阻害剤としてのピラゾール誘導体 |
KR20010012808A (ko) * | 1997-05-22 | 2001-02-26 | 윌리암스 로저 에이 | p38 키나아제로서 4-아릴-3(5)-헤테로아릴 치환 피라졸 |
US6409988B1 (en) * | 1999-07-01 | 2002-06-25 | 3-Dimensional Pharmaceuticals, Inc. | Radiolabeled 1-aryl pyrazoles, the synthesis thereof and the use thereof as pest GABA receptor ligands |
US6518266B1 (en) * | 1999-07-22 | 2003-02-11 | 3-Dimensional Pharmaceuticals | 1- Aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides |
GB0024807D0 (en) * | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
JP2002114765A (ja) * | 2000-10-11 | 2002-04-16 | Fuji Photo Film Co Ltd | 3−アミノ−4−カルボニルピラゾール化合物の製造方法 |
KR20040033048A (ko) * | 2001-09-14 | 2004-04-17 | 미츠비시 웰파마 가부시키가이샤 | 티아졸리딘 유도체 및 이의 약학적 용도 |
CA2464214C (en) * | 2001-10-22 | 2011-02-08 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them |
JP2003201271A (ja) * | 2001-10-25 | 2003-07-18 | Sankyo Co Ltd | 脂質モジュレーター |
US20030139427A1 (en) * | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
WO2004092140A1 (en) * | 2003-04-03 | 2004-10-28 | Merck & Co., Inc. | Biaryl substituted pyrazoles as sodium channel blockers |
SE0401653D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
DE102005042583A1 (de) * | 2005-09-08 | 2007-03-15 | Bayer Healthcare Ag | Iminooxazolidin-Derivate und ihre Verwendung |
KR20080080214A (ko) * | 2005-12-23 | 2008-09-02 | 아스트라제네카 아베 | 헤테로시클릭 gaba-b 조절제 |
JP2009521430A (ja) * | 2005-12-23 | 2009-06-04 | アストラゼネカ・アクチエボラーグ | Gaba−b受容体モジュレーター |
AU2006327316A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Imidazoles as GABA-B receptor modulators |
JP2009521428A (ja) * | 2005-12-23 | 2009-06-04 | アストラゼネカ・アクチエボラーグ | 胃腸疾患治療用のイミダゾール誘導体 |
US20080262064A1 (en) * | 2007-04-18 | 2008-10-23 | Astrazeneca Ab | Novel Compounds For The Treatment Of GI Disorders 682 |
AU2008241604A1 (en) * | 2007-04-18 | 2008-10-30 | Astrazeneca Ab | Xanthine compounds having a positive allosteric GABAB receptor modulator effect |
-
2006
- 2006-12-21 BR BRPI0620415-5A patent/BRPI0620415A2/pt not_active IP Right Cessation
- 2006-12-21 AU AU2006327314A patent/AU2006327314A1/en not_active Abandoned
- 2006-12-21 JP JP2008547164A patent/JP2009521427A/ja active Pending
- 2006-12-21 CN CNA2006800483496A patent/CN101341128A/zh active Pending
- 2006-12-21 US US12/158,203 patent/US20090062365A1/en not_active Abandoned
- 2006-12-21 CA CA002632011A patent/CA2632011A1/en not_active Abandoned
- 2006-12-21 EP EP06824531A patent/EP1966150A4/en not_active Withdrawn
- 2006-12-21 KR KR1020087018002A patent/KR20080090449A/ko not_active Application Discontinuation
- 2006-12-21 WO PCT/SE2006/001461 patent/WO2007073297A1/en active Application Filing
-
2008
- 2008-05-27 IL IL191765A patent/IL191765A0/en unknown
- 2008-06-17 ZA ZA200805240A patent/ZA200805240B/xx unknown
- 2008-07-22 NO NO20083243A patent/NO20083243L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20080090449A (ko) | 2008-10-08 |
BRPI0620415A2 (pt) | 2011-11-08 |
JP2009521427A (ja) | 2009-06-04 |
AU2006327314A1 (en) | 2007-06-28 |
CN101341128A (zh) | 2009-01-07 |
NO20083243L (no) | 2008-07-23 |
WO2007073297A1 (en) | 2007-06-28 |
CA2632011A1 (en) | 2007-06-28 |
IL191765A0 (en) | 2008-12-29 |
EP1966150A4 (en) | 2011-07-20 |
EP1966150A1 (en) | 2008-09-10 |
US20090062365A1 (en) | 2009-03-05 |
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