ZA200803403B - Botulinum neurotoxin a protein receptor and use thereof - Google Patents
Botulinum neurotoxin a protein receptor and use thereofInfo
- Publication number
- ZA200803403B ZA200803403B ZA200803403A ZA200803403A ZA200803403B ZA 200803403 B ZA200803403 B ZA 200803403B ZA 200803403 A ZA200803403 A ZA 200803403A ZA 200803403 A ZA200803403 A ZA 200803403A ZA 200803403 B ZA200803403 B ZA 200803403B
- Authority
- ZA
- South Africa
- Prior art keywords
- botulinum neurotoxin
- protein receptor
- homo sapiens
- polypeptide
- amino acid
- Prior art date
Links
- 108010057266 Type A Botulinum Toxins Proteins 0.000 title abstract 2
- 241000282414 Homo sapiens Species 0.000 abstract 3
- 102100030637 Synaptic vesicle glycoprotein 2C Human genes 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 101710084143 Synaptic vesicle glycoprotein 2C Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 101000584382 Homo sapiens Synaptic vesicle glycoprotein 2C Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005051789.7A DE102005051789B4 (de) | 2005-10-28 | 2005-10-28 | Der Botulinus Neurotoxin A Proteinrezeptor und seine Anwendungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200803403B true ZA200803403B (en) | 2009-02-25 |
Family
ID=37770829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200803403A ZA200803403B (en) | 2005-10-28 | 2008-04-17 | Botulinum neurotoxin a protein receptor and use thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8476024B2 (https=) |
| EP (1) | EP1940874B1 (https=) |
| JP (1) | JP2009513118A (https=) |
| KR (1) | KR20080068069A (https=) |
| AT (1) | ATE539088T1 (https=) |
| AU (1) | AU2006308122B2 (https=) |
| CA (1) | CA2627457C (https=) |
| DE (1) | DE102005051789B4 (https=) |
| ES (1) | ES2379513T3 (https=) |
| NZ (1) | NZ567312A (https=) |
| WO (1) | WO2007048638A2 (https=) |
| ZA (1) | ZA200803403B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004043009A1 (de) | 2004-09-06 | 2006-03-23 | Toxogen Gmbh | Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen |
| DE102005019302A1 (de) * | 2005-04-26 | 2006-11-16 | Toxogen Gmbh | Carrier zum Targeting von Nervenzellen |
| US7985554B2 (en) | 2005-10-14 | 2011-07-26 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin A receptor and the use thereof |
| WO2009008916A2 (en) | 2007-03-22 | 2009-01-15 | The Regents Of The University Of Californina | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| US9000131B2 (en) * | 2008-07-31 | 2015-04-07 | The Regents Of The University Of California | Antibodies that neutralize botulinum neurotoxins |
| US8771707B2 (en) * | 2008-09-30 | 2014-07-08 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin E receptors and uses thereof |
| US9243057B2 (en) | 2010-08-31 | 2016-01-26 | The Regents Of The University Of California | Antibodies for botulinum neurotoxins |
| UA116985C2 (uk) | 2012-05-30 | 2018-06-11 | Президент Енд Феллоуз Оф Гарвард Колледж | Рекомбінантний ботулінічний нейротоксин |
| WO2014079495A1 (en) * | 2012-11-21 | 2014-05-30 | Syntaxin Limited | Methods for the manufacture of proteolytically processed polypeptides |
| PT3274364T (pt) | 2015-03-26 | 2021-11-05 | Harvard College | Neurotoxina botulínica manipulada |
| KR101670188B1 (ko) | 2015-11-09 | 2016-10-27 | 충북대학교 산학협력단 | 보툴리눔 신경독소 ｅ형에 특이적인 폴리펩타이드 및 이의 용도 |
| EP3504226A1 (en) | 2016-08-24 | 2019-07-03 | President and Fellows of Harvard College | Engineered botulinum neurotoxin |
| KR102480965B1 (ko) | 2016-09-13 | 2022-12-26 | 알레간 인코포레이티드 | 안정화된 비단백질 클로스트리듐 독소 조성물 |
| KR101958312B1 (ko) * | 2017-09-06 | 2019-07-02 | 국방과학연구소 | 보툴리눔 a형 독소에 대한 항체 |
| IL272002A (en) | 2020-01-13 | 2021-07-29 | The Israel Institute Of Biological Res Iibr | Methods for identifying anti clostridial neurotoxin compounds |
| WO2023210585A1 (ja) * | 2022-04-25 | 2023-11-02 | 株式会社Jiksak Bioengineering | 標的化剤 |
| WO2025089343A1 (ja) * | 2023-10-25 | 2025-05-01 | 株式会社Jiksak Bioengineering | 抗シナプス小胞糖タンパク質２ｃ抗体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005016233A2 (en) | 2002-10-31 | 2005-02-24 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin b receptors and use thereof |
| CA2484115C (en) * | 2002-12-03 | 2007-01-30 | Ucb, S.A. | Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases |
| US7985554B2 (en) * | 2005-10-14 | 2011-07-26 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin A receptor and the use thereof |
-
2005
- 2005-10-28 DE DE102005051789.7A patent/DE102005051789B4/de not_active Expired - Fee Related
-
2006
- 2006-10-30 JP JP2008537015A patent/JP2009513118A/ja active Pending
- 2006-10-30 AT AT06806613T patent/ATE539088T1/de active
- 2006-10-30 AU AU2006308122A patent/AU2006308122B2/en not_active Ceased
- 2006-10-30 US US12/084,074 patent/US8476024B2/en active Active
- 2006-10-30 ES ES06806613T patent/ES2379513T3/es active Active
- 2006-10-30 NZ NZ567312A patent/NZ567312A/en not_active IP Right Cessation
- 2006-10-30 WO PCT/EP2006/010420 patent/WO2007048638A2/de not_active Ceased
- 2006-10-30 KR KR1020087011531A patent/KR20080068069A/ko not_active Ceased
- 2006-10-30 CA CA2627457A patent/CA2627457C/en active Active
- 2006-10-30 EP EP06806613A patent/EP1940874B1/de not_active Not-in-force
-
2008
- 2008-04-17 ZA ZA200803403A patent/ZA200803403B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8476024B2 (en) | 2013-07-02 |
| AU2006308122B2 (en) | 2011-06-30 |
| NZ567312A (en) | 2011-09-30 |
| EP1940874A2 (de) | 2008-07-09 |
| EP1940874B1 (de) | 2011-12-28 |
| DE102005051789B4 (de) | 2014-08-07 |
| DE102005051789A1 (de) | 2007-05-10 |
| WO2007048638A2 (de) | 2007-05-03 |
| KR20080068069A (ko) | 2008-07-22 |
| US20090252722A1 (en) | 2009-10-08 |
| CA2627457C (en) | 2014-05-13 |
| JP2009513118A (ja) | 2009-04-02 |
| WO2007048638A3 (de) | 2007-07-26 |
| CA2627457A1 (en) | 2007-05-03 |
| ES2379513T3 (es) | 2012-04-26 |
| AU2006308122A1 (en) | 2007-05-03 |
| ATE539088T1 (de) | 2012-01-15 |
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