DE69841102D1 - Monoklonaler antikörper gegen ein prion protein und dessen verwendung zum nachweis von prionen - Google Patents

Monoklonaler antikörper gegen ein prion protein und dessen verwendung zum nachweis von prionen

Info

Publication number
DE69841102D1
DE69841102D1 DE69841102T DE69841102T DE69841102D1 DE 69841102 D1 DE69841102 D1 DE 69841102D1 DE 69841102 T DE69841102 T DE 69841102T DE 69841102 T DE69841102 T DE 69841102T DE 69841102 D1 DE69841102 D1 DE 69841102D1
Authority
DE
Germany
Prior art keywords
monoclonal antibody
prion protein
antibody against
detecting prions
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69841102T
Other languages
English (en)
Inventor
Carsten Korth
Beat Stierli
Peter Streit
Bruno Oesch
Markus Moser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Zuerich
Original Assignee
Universitaet Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaet Zuerich filed Critical Universitaet Zuerich
Application granted granted Critical
Publication of DE69841102D1 publication Critical patent/DE69841102D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2872—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against prion molecules, e.g. CD230
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69841102T 1997-02-21 1998-02-18 Monoklonaler antikörper gegen ein prion protein und dessen verwendung zum nachweis von prionen Expired - Lifetime DE69841102D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97102837A EP0861900A1 (de) 1997-02-21 1997-02-21 Immunologischer Nachweis von Prionen
PCT/EP1998/000917 WO1998037210A1 (en) 1997-02-21 1998-02-18 Immunological detection of prions

Publications (1)

Publication Number Publication Date
DE69841102D1 true DE69841102D1 (de) 2009-10-08

Family

ID=8226511

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69841102T Expired - Lifetime DE69841102D1 (de) 1997-02-21 1998-02-18 Monoklonaler antikörper gegen ein prion protein und dessen verwendung zum nachweis von prionen

Country Status (8)

Country Link
US (2) US6765088B1 (de)
EP (3) EP0861900A1 (de)
AT (1) ATE440868T1 (de)
AU (1) AU742838B2 (de)
CA (1) CA2280791C (de)
DE (1) DE69841102D1 (de)
NZ (1) NZ336656A (de)
WO (1) WO1998037210A1 (de)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221614B1 (en) 1997-02-21 2001-04-24 The Regents Of The University Of California Removal of prions from blood, plasma and other liquids
US6620629B1 (en) 1997-02-21 2003-09-16 The Regents Of The University Of California Method for detecting prions
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US6617119B2 (en) 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
DE19741607A1 (de) * 1997-09-20 1999-03-25 Prionics Ag Synthetische Polypeptide zur Diagnose und Therapie von Prionerkrankungen
US6214565B1 (en) 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
GB2371049B (en) * 1998-11-04 2003-06-04 Imp College Innovations Ltd Methods of making antibodies against ß-forms of prion proteins and their uses
GB2362385B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Non-aggregated ß-forms of prion proteins
GB2348203B (en) 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
FI982480A0 (fi) * 1998-11-17 1998-11-17 Wallac Oy Immunomääritys nisäkkäiden tarttuvan spongiomuotoisen aivotaudin määrittämiseksi
FI982481A0 (fi) * 1998-11-17 1998-11-17 Wallac Oy Immunomääritys nautaeläinten tarttuvan spongiomuotoisen aivotaudin määrittämiseksi
WO2000043791A2 (en) 1999-01-25 2000-07-27 Minerva Biotechnologies Corporation Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
GB2346971B (en) * 1999-02-19 2004-07-21 Audrey Ann Coop Blood test for infectious prion protein using antibodies raised to eye lens crystallin proteins
DE19918141A1 (de) * 1999-04-21 2000-10-26 Boehringer Ingelheim Vetmed Verfahren zur Diagnose von übertragbaren Spongiformen Enzephalopathien
EP1194164B8 (de) * 1999-06-23 2007-03-21 IDEXX Laboratories Inc Prion protein peptide und deren verwendung
US7041807B1 (en) 1999-06-23 2006-05-09 Caprion Pharmaceuticals, Inc. Antibodies to a YYX epitope of a mammalian prion protein
AU780414B2 (en) * 1999-07-27 2005-03-17 D-Gen Limited Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases
EP1216258A1 (de) * 1999-09-28 2002-06-26 Universität Zürich Faktoren mit prionen bindender aktivität im serum und plasma sowie mittel zur bestimmung von übertragbaren spongiformen encephalopathien
FR2801106B1 (fr) 1999-11-12 2007-10-05 Commissariat Energie Atomique Procede de diagnostic d'une esst provoquee par une souche d'atnc dans un echantillon biologique et son utilisation dans le diagnostic differentiel des differentes souches d'atnc
EP1240526A2 (de) 1999-12-15 2002-09-18 The Regents of the University of California Konformationale und topologische protein-regulation
DK1261875T3 (da) 2000-03-10 2007-11-26 Univ Geneve Diagnostisk analyse for transmissibel spongiform encephalopati
GB2360089A (en) * 2000-03-10 2001-09-12 Univ Geneve Diagnostic assay for transmisible spongiform encephalopathies
FR2808278A1 (fr) * 2000-04-28 2001-11-02 Inst Nat Sante Rech Med Proteines a prions et leurs utilisations
US7098317B1 (en) * 2000-05-23 2006-08-29 Blood Transfusion Center Of Slovenia Antibodies capable to selectively detect prion PrPSc isoforms
EP1158003B2 (de) * 2000-05-23 2012-12-26 Blood Transfusion Centre of Slovenia Antikörper zum selektiven Nachweis von Prion PrP Sc Isoformen
IL141950A0 (en) * 2000-10-22 2002-03-10 Hadasit Med Res Service Diagnosis of prion diseases
NZ515982A (en) * 2000-12-08 2003-09-26 Fujirebio Kk Method and monoclonal antibodies for differentiation between abnormal and normal prions
US7303907B2 (en) 2001-01-08 2007-12-04 Health Protection Agency Degradation and detection of TSE infectivity
US20020137114A1 (en) * 2001-01-19 2002-09-26 Dirk Voelkel Method of detecting PrP protein and kits therefor
IES20010042A2 (en) * 2001-01-19 2002-12-11 Enfer Technology Ltd Test for transmissible spongiform encephalopathies
DE10104480A1 (de) * 2001-01-31 2002-08-14 November Ag Molekulare Medizin Verfahren, Verwendung und Kit zum Auffinden von Wirkstoffen gegen mit spezifischen Proteinen assoziierte Krankheiten
DE10106835A1 (de) * 2001-02-14 2002-09-05 Basf Lynx Bioscience Ag Signaltransduktionsproteine 15B3, 15B3-1 und 15B3-2 und zugrundeliegende DNA-Sequenzen
DE10120562C2 (de) * 2001-04-26 2003-04-10 Horst Messer Verfahren zur Diagnose von übertragbaren spongiformen Enzephalopathien
DE60217107T2 (de) * 2001-06-20 2007-08-23 Ramot At Tel Aviv University Ltd. Mehrantigenisches peptid enthaltend mehrere kopien eines epitopes von einem ablagerungsformenden polypeptid und dessen verwendung
DE10143647A1 (de) * 2001-09-05 2003-03-27 Prionics Ag Zuerich DNA-Sequenzen codierend für variable Bereiche von Antikörpern, die an das Prion-Protein (PrP) binden sowie PrP-bindende Polypeptide
AU2002349311B2 (en) * 2001-09-25 2007-11-08 Prionics Ag Test strips for the detection of prion proteins
US7045297B2 (en) 2001-11-14 2006-05-16 Prion Developmental Laboratories, Inc. Rapid prion-detection assay
US20030092090A1 (en) * 2001-11-14 2003-05-15 Kiamars Hajizadeh Rapid prion-detection device, system, and test kit
EP1312617A1 (de) 2001-11-14 2003-05-21 ATOFINA Research Schlagzähes Polypropen
US20030092199A1 (en) * 2001-11-14 2003-05-15 Kiamars Hajizadeh Prion-detection business methods
AU2003280457A1 (en) * 2002-06-27 2004-01-19 University Of Marlyland, Baltimore Methods for detecting and inactivating a prion
EP1382971A1 (de) * 2002-07-17 2004-01-21 Pepscan Systems B.V. Nachweis von Prion Erkrankung
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
AU2002352042A1 (en) * 2002-11-18 2004-06-15 Prionics Ag Method for the detection of prpsc
GB0227886D0 (en) * 2002-11-29 2003-01-08 Medical Res Council Prion inhibition
US7399603B2 (en) 2002-12-19 2008-07-15 Ortho-Clinical Diagnostics, Inc. Antibodies for discrimination of prions
AU2003266801B2 (en) * 2002-12-19 2010-02-25 Ortho-Clinical Diagnostics, Inc Detection and diagnosis of transmissable spongiform encephalopathies
FR2849204B1 (fr) * 2002-12-20 2005-02-11 Afssa Procede de detection de la prpsc utilisant un antibiotique d de la famille des aminoglycosides pour l'elimination et la detection de la prpsc dans des echantillons biologiques
AU2004200467A1 (en) * 2003-02-10 2004-08-26 Ortho-Clinical Diagnostics, Inc. Antibodies for discrimination of prions
EP1457500A1 (de) * 2003-03-14 2004-09-15 University of Zurich Lösliche Prionen-Hybrid-Proteine und deren Verwendung zur Diagnose, Behandlung und Prevention von transmissibler spongiformer Encephalopathie
EP1653844B1 (de) 2003-08-13 2012-12-12 Novartis Vaccines and Diagnostics, Inc. Prion-spezifische peptid-reagenzien
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US20070003977A1 (en) * 2003-08-20 2007-01-04 Amorfix Life Sciences Ltd Epitope protection assay and method for detecting protein conformations
US20050214805A1 (en) * 2003-11-10 2005-09-29 Q-Rna, Inc. Methods of detection employing immuno-Q-Amp technology
US20060199194A1 (en) * 2003-11-10 2006-09-07 Q-Rna, Inc. Methods of detection using immuno-Q-Amp technology
EP1596199A1 (de) * 2004-05-14 2005-11-16 Prionics AG Verfahren zum Nachweis von pathogenen Prionenproteinen.
AU2005209592B2 (en) 2004-09-30 2012-07-12 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
US20090099343A1 (en) * 2005-01-13 2009-04-16 David Peretz Isolation of pathogenic prions
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
JP5162250B2 (ja) * 2005-01-13 2013-03-13 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド プリオン特異的ペプチド試薬を使用するｅｌｉｓａアッセイ
GB0501564D0 (en) * 2005-01-25 2005-03-02 Univ Cambridge Tech Test for prion disease
WO2006102099A2 (en) * 2005-03-18 2006-09-28 The Regents Of The University Of California ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP
US20070015211A1 (en) * 2005-06-22 2007-01-18 Prosetta Corporation Conformer-specific antibodies and method of use, thereof
KR20080048527A (ko) 2005-09-09 2008-06-02 노파르티스 아게 프리온-특이적 펩토이드 시약
US7794692B2 (en) * 2005-12-02 2010-09-14 Amorfix Life Sciences Ltd. Methods and compositions for detecting amyotrophic lateral sclerosis
US7887803B2 (en) 2005-12-02 2011-02-15 Amorfix Life Sciences Methods and compositions to treat misfolded-SOD1 mediated diseases
EP1989308B1 (de) * 2006-03-03 2017-05-31 ProMIS Neurosciences Inc. Verfahren und zusammensetzungen zum behandeln und erkennen von missgefaltetem sod1-herbeigeführte erkrankungen
CA2649359A1 (en) * 2006-04-21 2007-11-01 Peoplebio, Inc. Method for differentially detecting multimeric form from monomeric form of multimer-forming polypeptides through three-dimensional interactions
US8492097B2 (en) 2006-04-24 2013-07-23 Diagnostic Hybrids, Inc. Compositions and methods for human metapneumovirus monoclonal antibodies
WO2008029965A1 (en) * 2006-09-08 2008-03-13 Peoplebio, Inc. Simultaneous reaction assay for differentially detecting multimeric form
US8013122B2 (en) 2006-12-20 2011-09-06 Kieu Hoang Method of purifying apolipoprotein A-1
JP2011520108A (ja) * 2008-04-30 2011-07-14 ノバルティス アーゲー 病原性配座異性体についてのアッセイ
TWI560197B (en) * 2009-05-05 2016-12-01 Amgen Inc Fgf21 mutants and uses thereof
WO2011137447A1 (en) 2010-04-30 2011-11-03 Prostetta Antiviral Inc. Antiviral compounds
US8759336B2 (en) 2011-03-17 2014-06-24 Prosetta Antiviral Inc. Antiviral compounds
WO2012145567A1 (en) 2011-04-20 2012-10-26 Prosetta Antiviral Inc. Antiviral compounds
US20120301904A1 (en) 2011-04-26 2012-11-29 Prosetta Antiviral, Inc Multiprotein assemblies
CN103044546B (zh) * 2011-11-24 2015-09-30 上海转基因研究中心 一种朊蛋白抗体及其制备方法和应用
CN102565410B (zh) * 2012-01-12 2014-08-06 吉林大学 一种梅花鹿朊蛋白免疫学检测方法
CN102558349B (zh) * 2012-01-12 2013-12-11 吉林大学 一种识别天然结构梅花鹿朊蛋白的单克隆抗体及制备方法
US9226038B2 (en) 2012-11-12 2015-12-29 Roger B. and Ann K. McNamee Trust U/T/A/D Systems and methods for communicating a live event to users using the internet
FR2998373B1 (fr) 2012-11-20 2015-01-09 Franklab Sas Procede de mesure de l'aptitude d'une formulation a inactiver un atnc.
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
JP6716799B1 (ja) * 2020-02-07 2020-07-01 三菱日立パワーシステムズ株式会社 温度計保護筒、温度計測器具及び蒸気配管構造物並びに温度計保護筒の設置方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0616613T3 (da) * 1991-12-03 1999-09-27 Proteus Molecular Design Fragmenter af prionprotein
WO1993023432A1 (en) * 1992-05-15 1993-11-25 New York University Soluble prion polypeptides, and methods for detecting and purifying thereof
ES2218598T3 (es) * 1995-09-14 2004-11-16 The Regents Of The University Of California Anticuerpo especifico del prpsc natural.

Also Published As

Publication number Publication date
CA2280791C (en) 2011-06-21
ATE440868T1 (de) 2009-09-15
WO1998037210A1 (en) 1998-08-27
AU6498698A (en) 1998-09-09
EP0861900A1 (de) 1998-09-02
US6765088B1 (en) 2004-07-20
CA2280791A1 (en) 1998-08-27
EP2172486B1 (de) 2014-11-05
EP2172486A2 (de) 2010-04-07
NZ336656A (en) 2002-05-31
US20060025575A1 (en) 2006-02-02
EP2172486A3 (de) 2012-02-29
EP1007700B1 (de) 2009-08-26
EP1007700A1 (de) 2000-06-14
US7259246B2 (en) 2007-08-21
AU742838B2 (en) 2002-01-10

Similar Documents

Publication Publication Date Title
DE69841102D1 (de) Monoklonaler antikörper gegen ein prion protein und dessen verwendung zum nachweis von prionen
WO1998050433A3 (en) Human monoclonal antibodies to epidermal growth factor receptor
DK0929564T3 (da) Höjniveau-ekspression af proteiner
AU2152299A (en) Multivalent antigen-binding proteins
ZA200800555B (en) IL-1² binding antibodies and fragments thereof
EP1625163B8 (de) Verfahren zum nachweis von probnp mit einem monoklonalen antikörper, der die amino saüre 38-43 bindet
DK0851868T3 (da) Höjniveau-ekspression af proteiner
NO994146L (no) Celleoverflatemolekyl som formidler celleadhesjon og signatransmisjon
BR9809778A (pt) Polinucleotìdeo isolado, vetor de expressão, peptìdeo ou polipetìdeo isolado, anticorpo, processo para produzir o mesmo, fragmentos de anticorpos, anticorpos de cadeia única ou anticorpos humanizados, e, anticorpo anti-idiotìpico.
ATE368688T1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
DE59914490D1 (de) Ein faktor viii-polypeptid mit faktor viii:c-aktivität
BR9912455A (pt) ácidos nucléicos codificadores de proteìnas envolvidas em transdução sensória
DE502005004379D1 (de) Gegen den Marburg I Polymorphismus der Faktor VII aktivierenden Protease (FSAP) gerichtete Antikörper, ihre Herstellung und Verwendung
BR9606557A (pt) Anticorpo monoclonal hibridoma polipeptídeo purificado e isolado polinucleotídeo purificado e isolado DNA célula hospedeira e método para produzir o polipeptídeo
WO2003061561A8 (en) Epsilon immunoglobulin chain derived peptides for induction of anti-ige antibodies
WO2002002620A3 (en) Crmp-5 (collapsin response-mediator protein) encoding nucleic acid, polypeptide and uses thereof
ATE405646T1 (de) Ein verfahren zum auffinden vom prostatakrebs
MX9701904A (es) Proteinas de enlace de pka novedosas y usos de las mismas.
ATE382639T1 (de) Anti-humane thymidylat-synthase monoklonale antikörper und hybridomazellen zu deren herstellung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition