ZA200801519B - (Indol-3-yl)-heterocycle derivatives as agonists of the cannabinoid CB1 receptor - Google Patents

(Indol-3-yl)-heterocycle derivatives as agonists of the cannabinoid CB1 receptor

Info

Publication number
ZA200801519B
ZA200801519B ZA200801519A ZA200801519A ZA200801519B ZA 200801519 B ZA200801519 B ZA 200801519B ZA 200801519 A ZA200801519 A ZA 200801519A ZA 200801519 A ZA200801519 A ZA 200801519A ZA 200801519 B ZA200801519 B ZA 200801519B
Authority
ZA
South Africa
Prior art keywords
cannabinoid
indol
agonists
receptor
heterocycle derivatives
Prior art date
Application number
ZA200801519A
Other languages
English (en)
Inventor
Ratcliffe Paul David
Morrison Angus John
Kiyoi Takao
Adam-Worrall Julia
Francis Stuart John
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of ZA200801519B publication Critical patent/ZA200801519B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
ZA200801519A 2005-08-23 2008-02-14 (Indol-3-yl)-heterocycle derivatives as agonists of the cannabinoid CB1 receptor ZA200801519B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05107725 2005-08-23

Publications (1)

Publication Number Publication Date
ZA200801519B true ZA200801519B (en) 2008-12-31

Family

ID=35539284

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200801519A ZA200801519B (en) 2005-08-23 2008-02-14 (Indol-3-yl)-heterocycle derivatives as agonists of the cannabinoid CB1 receptor

Country Status (18)

Country Link
EP (1) EP1919471B1 (de)
JP (1) JP5283505B2 (de)
KR (1) KR20080038239A (de)
CN (1) CN101272783B (de)
AR (1) AR055384A1 (de)
AU (1) AU2006283884B2 (de)
BR (1) BRPI0615201A2 (de)
CA (1) CA2619038A1 (de)
EC (1) ECSP088270A (de)
IL (1) IL189390A0 (de)
MX (1) MX2008002539A (de)
NO (1) NO20080750L (de)
NZ (1) NZ566007A (de)
PE (1) PE20070236A1 (de)
RU (1) RU2008110961A (de)
TW (1) TW200745096A (de)
WO (1) WO2007023143A1 (de)
ZA (1) ZA200801519B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI330635B (en) 2004-03-05 2010-09-21 Organon Nv (indol-3-yl)-heterocycle derivatives
US7763732B2 (en) 2005-08-24 2010-07-27 N.V. Organon Indole derivatives
TW200848417A (en) * 2007-02-22 2008-12-16 Organon Nv Indole derivatives
WO2008119694A1 (en) * 2007-03-30 2008-10-09 Janssen Pharmaceutica Nv Benzimidazole cannabinoid agonists
JP5569397B2 (ja) 2009-01-16 2014-08-13 ダイソー株式会社 ２−ヒドロキシメチルモルホリン塩の製造方法
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
KR102114323B1 (ko) * 2013-12-09 2020-05-22 이니스트에스티 주식회사 광학활성 1-(인돌린-5-일)프로판-2-올 유도체의 제조방법
AU2016354009B2 (en) 2015-11-09 2021-05-20 R.P. Scherer Technologies, Llc Anti-CD22 antibody-maytansine conjugates and methods of use thereof
MX2018006802A (es) * 2015-12-09 2018-09-05 Hoffmann La Roche Derivados de fenilo como agonistas del receptor de canabinoides 2.
JP7453365B2 (ja) * 2020-05-29 2024-03-19 富士フイルム富山化学株式会社 高純度のｎ－（５－メトキシ―２－フェノキシフェニル）メタンスルホンアミド及びその製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR118000A0 (en) * 2000-11-02 2000-11-23 Amrad Operations Pty. Limited Therapeutic molecules and methods
TW200402417A (en) * 2002-06-21 2004-02-16 Akzo Nobel Nv 1-[(Indol-3-yl)carbonyl]piperazine derivatives
BR0314872A (pt) * 2002-10-18 2005-08-02 Pfizer Prod Inc Ligandos do receptor canabinóide e usos dos mesmos
US7247628B2 (en) * 2002-12-12 2007-07-24 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
TWI330635B (en) * 2004-03-05 2010-09-21 Organon Nv (indol-3-yl)-heterocycle derivatives

Also Published As

Publication number Publication date
EP1919471B1 (de) 2014-01-08
JP2009506010A (ja) 2009-02-12
ECSP088270A (es) 2008-04-28
CA2619038A1 (en) 2007-03-01
NZ566007A (en) 2009-12-24
CN101272783B (zh) 2011-05-25
AU2006283884A1 (en) 2007-03-01
RU2008110961A (ru) 2009-09-27
MX2008002539A (es) 2008-03-14
PE20070236A1 (es) 2007-04-16
BRPI0615201A2 (pt) 2011-05-10
JP5283505B2 (ja) 2013-09-04
KR20080038239A (ko) 2008-05-02
NO20080750L (no) 2008-05-14
TW200745096A (en) 2007-12-16
WO2007023143A1 (en) 2007-03-01
AR055384A1 (es) 2007-08-22
AU2006283884B2 (en) 2011-06-02
EP1919471A1 (de) 2008-05-14
CN101272783A (zh) 2008-09-24
IL189390A0 (en) 2008-06-05

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