ZA200709851B - Inhibitors of VEGF receptor and HGF receptor signaling - Google Patents

Inhibitors of VEGF receptor and HGF receptor signaling

Info

Publication number
ZA200709851B
ZA200709851B ZA200709851A ZA200709851A ZA200709851B ZA 200709851 B ZA200709851 B ZA 200709851B ZA 200709851 A ZA200709851 A ZA 200709851A ZA 200709851 A ZA200709851 A ZA 200709851A ZA 200709851 B ZA200709851 B ZA 200709851B
Authority
ZA
South Africa
Prior art keywords
receptor
inhibitors
hgf
signaling
vegf
Prior art date
Application number
ZA200709851A
Other languages
English (en)
Inventor
Saavedra Oscar Mario
Zhan Lijie
Vaisburg Arkadii
Deziel Robert
Nancy Z Zhou
Claridge Stephen William
Raeppel Franck
Raeppel Stephane
Mannion Michael
Isakovic Ljubomir
Original Assignee
Methylgene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Methylgene Inc filed Critical Methylgene Inc
Publication of ZA200709851B publication Critical patent/ZA200709851B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200709851A 2005-05-20 2007-11-15 Inhibitors of VEGF receptor and HGF receptor signaling ZA200709851B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68303805P 2005-05-20 2005-05-20

Publications (1)

Publication Number Publication Date
ZA200709851B true ZA200709851B (en) 2009-08-26

Family

ID=38023642

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200709851A ZA200709851B (en) 2005-05-20 2007-11-15 Inhibitors of VEGF receptor and HGF receptor signaling

Country Status (15)

Country Link
US (2) US7790729B2 (fr)
EP (1) EP1904504B1 (fr)
JP (1) JP5275792B2 (fr)
KR (1) KR101078968B1 (fr)
CN (1) CN101248080B (fr)
AU (1) AU2006313456B2 (fr)
BR (1) BRPI0610382A2 (fr)
CA (1) CA2608726C (fr)
DK (1) DK1904504T3 (fr)
ES (1) ES2473341T3 (fr)
IL (1) IL187422A0 (fr)
MX (1) MX2007014617A (fr)
NZ (1) NZ563774A (fr)
WO (1) WO2007054831A2 (fr)
ZA (1) ZA200709851B (fr)

Families Citing this family (32)

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US7202363B2 (en) 2003-07-24 2007-04-10 Abbott Laboratories Thienopyridine and furopyridine kinase inhibitors
MXPA06013996A (es) 2004-06-02 2007-02-08 Takeda Pharmaceutical Compuesto heterociclico fusionado.
MX2007001216A (es) * 2004-07-30 2007-03-23 Methylgene Inc Inhibidores de la senalizacion del receptor del factor de crecimiento endotelial vascular y del receptor del factor de crecimiento del hepatocito.
AU2006229343A1 (en) * 2005-03-28 2006-10-05 Kirin Pharma Kabushiki Kaisha Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency
CA2636242A1 (fr) * 2006-01-30 2008-05-29 Array Biopharma, Inc. Composes heterobicycliques de thiophene et leurs methodes d'utilisation
CA2655128A1 (fr) * 2006-06-08 2007-12-21 Array Biopharma Inc. Quinolines et methodes d'utilisation
AU2007287428B2 (en) 2006-08-24 2011-08-11 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
US8138183B2 (en) 2007-07-09 2012-03-20 Astrazeneca Ab Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K
US8907091B2 (en) 2007-08-29 2014-12-09 Methylgene Inc. Processes and intermediates for preparing fused heterocyclic kinase inhibitors
JP5656634B2 (ja) * 2007-08-29 2015-01-21 メチルジーン インコーポレイテッド タンパク質チロシンキナーゼ活性の阻害剤
WO2009109035A1 (fr) * 2008-03-05 2009-09-11 Methylgene Inc. Inhibiteurs d'activité de protéine tyrosine kinase
MX2011004535A (es) * 2008-10-29 2011-11-18 Deciphera Pharmaceuticals Llc Ciclopropanamidas y analogos que exhiben actividades anti-cancer y anti-proliferativas.
BRPI0921392A2 (pt) 2008-12-05 2016-04-26 Abbott Lab inibidores quinase com perfil de segurança cyp aperfeiçoado
US9340555B2 (en) 2009-09-03 2016-05-17 Allergan, Inc. Compounds as tyrosine kinase modulators
NZ598455A (en) 2009-09-03 2014-03-28 Allergan Inc Compounds as tyrosine kinase modulators
AR080871A1 (es) * 2010-04-16 2012-05-16 Otsuka Pharma Co Ltd Tieno[3,2-b]piridinas sustituidas como inhibidores de la actividad de la proteina tirosina quinasa
SA111320519B1 (ar) 2010-06-11 2014-07-02 Astrazeneca Ab مركبات بيريميدينيل للاستخدام كمثبطات atr
US8664244B2 (en) 2010-09-12 2014-03-04 Advenchen Pharmaceuticals, LLC Compounds as c-Met kinase inhibitors
BR112013006016A2 (pt) 2010-09-15 2016-06-07 Hoffmann La Roche compostos de azabenzotiazol, composições e métodos de uso
CN102153579B (zh) * 2011-02-23 2013-05-29 兰州米诺生物科技有限公司 氮-叔丁氧羰基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
CN102827186A (zh) * 2011-06-16 2012-12-19 中国科学院上海药物研究所 一类吡啶并五元杂环衍生物及其制备方法和用途
CA2841111A1 (fr) 2011-07-08 2013-01-17 Novartis Ag Nouveaux derives de pyrrolopyrimidine
US8436179B2 (en) 2011-07-20 2013-05-07 Abbvie Inc. Kinase inhibitor with improved solubility profile
US9216954B2 (en) 2012-01-27 2015-12-22 National University Corporation University Of Toyama Serine racemase inhibitor
GB2499666A (en) * 2012-02-27 2013-08-28 Nanyang Polytechnic Mcl-1 inhibitors for the treatment of conditions associated with proliferative disorders
TWI520962B (zh) * 2012-06-29 2016-02-11 As the c-Met tyrosine kinase inhibitors novel fused pyridine derivatives
CN104507930B (zh) * 2012-06-29 2017-10-10 贝达药业股份有限公司 作为c‑Met酪氨酸激酶抑制剂的新型稠合吡啶衍生物
US9925193B2 (en) 2012-11-20 2018-03-27 Proqinase Gmbh Thioether derivatives as protein kinase inhibitors
CN103396417B (zh) * 2013-08-14 2015-02-04 冯子侠 新型羟肟酸衍生物及其医疗应用
CN106995452B (zh) * 2016-12-22 2018-03-16 湖北民族学院 一种噻吩并[3，2‑d]嘧啶类EGFR/ErbB2双靶点抑制剂及其制备方法和用途
US11168093B2 (en) 2018-12-21 2021-11-09 Celgene Corporation Thienopyridine inhibitors of RIPK2
US10702525B1 (en) 2019-09-04 2020-07-07 United Arab Emirates University Pyrimidine derivatives as anti-diabetic agents

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US6107300A (en) * 1996-03-27 2000-08-22 Dupont Pharmaceuticals Arylamino fused pyrimidines
ID23978A (id) * 1997-11-11 2000-06-14 Pfizer Prod Inc Turunan-turunan tienopirimidin dan tienopiridin yang berguna sebagai zat-zat anti kangker
SK18542000A3 (sk) 1998-06-04 2001-12-03 Abbott Laboratories Protizápalové zlúčeniny inhibujúce bunkovú adhéziu
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
WO2000075145A1 (fr) 1999-06-03 2000-12-14 Abbott Laboratories Composes anti-inflammatoires inhibant l'adhesion cellulaire
PT1287001E (pt) 2000-06-06 2004-12-31 Pfizer Prod Inc Derivados de tiofeno uteis como agentes anticancerigenos
US20020004511A1 (en) * 2000-06-28 2002-01-10 Luzzio Michael Joseph Thiophene derivatives useful as anticancer agents
US6488261B1 (en) * 2001-02-21 2002-12-03 Jen-Chieh Lee Ball valve
AU2002345792A1 (en) 2001-06-21 2003-01-08 Pfizer Inc. Thienopyridine and thienopyrimidine anticancer agents
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
DE60233736D1 (de) * 2001-06-22 2009-10-29 Kirin Pharma K K Chinolinderivat und chinazolinderivat, die die selbstphosphorylierung des hepatocytus-proliferator-rezeptors hemmen, und diese enthaltende medizinische zusammensetzung
MXPA04008403A (es) * 2002-03-01 2004-11-26 Pfizer Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso.
US20030199525A1 (en) 2002-03-21 2003-10-23 Hirst Gavin C. Kinase inhibitors
CL2003002287A1 (es) 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
JP2007504122A (ja) 2003-08-29 2007-03-01 ファイザー・インク 新規抗血管形成剤として有用なチエノピリジン−フェニルアセトアミドおよびその誘導体
WO2005052872A1 (fr) * 2003-11-21 2005-06-09 Facil, Llc Systeme et procede de transaction financiere
WO2005073224A2 (fr) 2004-01-23 2005-08-11 Amgen Inc Composes et methodes d'utilisation de ces derniers
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
WO2005121125A1 (fr) * 2004-06-09 2005-12-22 Pfizer Inc. Composes heteroaryle a liaison ether
US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7439246B2 (en) * 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
WO2006014325A2 (fr) * 2004-07-02 2006-02-09 Exelixis, Inc. Modulateurs de c-met et leur methode d'utilisation
EP1768984B1 (fr) 2004-07-16 2010-10-20 Sunesis Pharmaceuticals, Inc. Thienopyrimidines utiles en tant qu'inhibiteurs des kinases aurora
MX2007001216A (es) * 2004-07-30 2007-03-23 Methylgene Inc Inhibidores de la senalizacion del receptor del factor de crecimiento endotelial vascular y del receptor del factor de crecimiento del hepatocito.
AU2006229343A1 (en) * 2005-03-28 2006-10-05 Kirin Pharma Kabushiki Kaisha Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
KR101378716B1 (ko) * 2005-05-20 2014-04-10 메틸진 인코포레이티드 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달의 억제제
CA2636242A1 (fr) 2006-01-30 2008-05-29 Array Biopharma, Inc. Composes heterobicycliques de thiophene et leurs methodes d'utilisation

Also Published As

Publication number Publication date
US20060287343A1 (en) 2006-12-21
EP1904504A2 (fr) 2008-04-02
CN101248080B (zh) 2012-09-05
NZ563774A (en) 2010-04-30
EP1904504A4 (fr) 2010-06-02
ES2473341T3 (es) 2014-07-04
WO2007054831A3 (fr) 2007-10-04
CN101248080A (zh) 2008-08-20
MX2007014617A (es) 2008-02-11
CA2608726C (fr) 2013-07-09
US7790729B2 (en) 2010-09-07
EP1904504B1 (fr) 2014-03-19
US20100249145A1 (en) 2010-09-30
JP2008540639A (ja) 2008-11-20
AU2006313456B2 (en) 2011-06-23
WO2007054831A2 (fr) 2007-05-18
CA2608726A1 (fr) 2007-05-18
AU2006313456A1 (en) 2007-05-18
JP5275792B2 (ja) 2013-08-28
KR101078968B1 (ko) 2011-11-01
IL187422A0 (en) 2008-02-09
DK1904504T3 (da) 2014-06-23
BRPI0610382A2 (pt) 2010-06-15
KR20080027782A (ko) 2008-03-28

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